Thibaut Larcher
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View article: The MARK2 kinase acts as a gatekeeper of CD28-dependent co-stimulation in T cells
The MARK2 kinase acts as a gatekeeper of CD28-dependent co-stimulation in T cells Open
Naïve T cell activation requires not only antigen recognition through the TCR but also a co-stimulatory signal, mainly provided by CD28. Here, using a T cell–specific conditional knockout (cKO) model, we identify the microtubule-affinity k…
View article: Dose- and genotype-dependent cardiac arrhythmia and sudden death in rats following microdystrophin gene therapy
Dose- and genotype-dependent cardiac arrhythmia and sudden death in rats following microdystrophin gene therapy Open
Recombinant adeno-associated virus (rAAV) vectors encoding microdystrophin (MD) are a promising treatment for Duchenne muscular dystrophy (DMD). GNT0004, an rAAV2/8 vector expressing MD1, is currently being tested in patients with DMD. Her…
View article: Sphingolipids in Extracellular Vesicles Released From the Skeletal Muscle Plasma Membrane Control Muscle Stem Cell Fate During Muscle Regeneration
Sphingolipids in Extracellular Vesicles Released From the Skeletal Muscle Plasma Membrane Control Muscle Stem Cell Fate During Muscle Regeneration Open
Extracellular vesicles (EVs) represent a cytokine‐independent pathway though which skeletal muscle (SkM) cells influence the fate of neighbouring cells, thereby regulating SkM metabolic homeostasis and regeneration. Although SkM‐EVs are in…
View article: MEK inhibition prevents human skin graft rejection by promoting CD8+TCF1+ over CD8 effector T cells
MEK inhibition prevents human skin graft rejection by promoting CD8+TCF1+ over CD8 effector T cells Open
View article: Marek’s disease virus replication in chicken skin reconstructed in vitro: evidence for viral particles in corneocytes
Marek’s disease virus replication in chicken skin reconstructed in vitro: evidence for viral particles in corneocytes Open
Marek’s disease (MD) is a lethal lymphoma of chickens, which is caused by MD virus (MDV), an alphaherpesvirus. MDV infects epithelial cells of the skin appendages, notably feather follicles, replicates in these cells and is shed into the e…
View article: Multiscale physiological responses to organic and inorganic pollution in the invasive mosquitofish Gambusia holbrooki
Multiscale physiological responses to organic and inorganic pollution in the invasive mosquitofish Gambusia holbrooki Open
View article: Advancing liver gene therapy: Enhanced transduction with GalNAc-bioconjugated rAAV capsids
Advancing liver gene therapy: Enhanced transduction with GalNAc-bioconjugated rAAV capsids Open
This study explores a novel strategy to enhance liver-targeted gene delivery, crucial for treating metabolic disorders. While AAV-based gene therapy holds promise, high vector doses raise safety concerns, often requiring the use of cortico…
View article: Swine influenza A virus infection sets the local immunological landscape in subsequent infection with porcine reproductive and respiratory syndrome virus
Swine influenza A virus infection sets the local immunological landscape in subsequent infection with porcine reproductive and respiratory syndrome virus Open
View article: POS1432 MECHANISMS OF CD45RChigh T AND B CELL DEPLETION BY AN ANTI-CD45RC mAb IN EXPERIMENTAL RHEUMATOID ARTHRITIS
POS1432 MECHANISMS OF CD45RChigh T AND B CELL DEPLETION BY AN ANTI-CD45RC mAb IN EXPERIMENTAL RHEUMATOID ARTHRITIS Open
View article: Juveniles at risk: behaviour and colour changes in sole juveniles (Solea solea) after exposure to estuarine ragworms (Hediste diversicolor) contaminated with microplastics
Juveniles at risk: behaviour and colour changes in sole juveniles (Solea solea) after exposure to estuarine ragworms (Hediste diversicolor) contaminated with microplastics Open
View article: The prion-family protein Doppel exerts a protective role during influenza virus infection
The prion-family protein Doppel exerts a protective role during influenza virus infection Open
The cellular form of the prion protein (PrPC), known for its involvement as a misfolded isoform in transmissible spongiform encephalopathies, has recently been identified to exert a protective effect against viral infections. In this study…
View article: Mini-GRID therapy delivers optimised spatially fractionated radiation therapy using a flattening free filter accelerator
Mini-GRID therapy delivers optimised spatially fractionated radiation therapy using a flattening free filter accelerator Open
The possibility to treat both large and small tumours, and to perform safe and potentially curative dose escalations in previously untreatable cases, makes mini-GRID a promising approach to expand the clinical use of SFRT.
View article: Flagellin aerosol administration improves the efficacy of antibiotic treatment in <i>Actinobacillus pleuropneumoniae</i> infected pigs
Flagellin aerosol administration improves the efficacy of antibiotic treatment in <i>Actinobacillus pleuropneumoniae</i> infected pigs Open
Swine infections with Actinobacillus pleuropneumoniae ( App ), the causative agent of porcine pleuropneumonia, lead to significant production losses. Surviving pigs may harbor antibiotic-resistant bacteria, highlighting the need for altern…
View article: On the significance of peak dose in normal tissue toxicity in spatially fractionated radiotherapy: The case of proton minibeam radiation therapy
On the significance of peak dose in normal tissue toxicity in spatially fractionated radiotherapy: The case of proton minibeam radiation therapy Open
While our study does not exclude the relevant role of the valley dose in tissue sparing, it does highlight the importance of peak doses, contradicting previous assumptions. Our results agree with the conclusion of a recent retrospective ev…
View article: Swine Influenza A virus infection sets the local immunological landscape in subsequent infection with Porcine Reproductive and Respiratory Syndrome virus
Swine Influenza A virus infection sets the local immunological landscape in subsequent infection with Porcine Reproductive and Respiratory Syndrome virus Open
Farmed pigs are frequently exposed to respiratory infections, with swine influenza A virus (swIAV) and porcine reproductive and respiratory syndrome virus (PRRSV) being key drivers. Most co-infection studies with these viruses have focused…
View article: Multiscale Physiological Responses to Organic and Inorganic Pollution in the Invasive Mosquitofish Gambusia Holbrooki
Multiscale Physiological Responses to Organic and Inorganic Pollution in the Invasive Mosquitofish Gambusia Holbrooki Open
View article: Omega-3 Fatty Acid and Vitamin D Supplementations Partially Reversed Metabolic Disorders and Restored Gut Microbiota in Obese Wistar Rats
Omega-3 Fatty Acid and Vitamin D Supplementations Partially Reversed Metabolic Disorders and Restored Gut Microbiota in Obese Wistar Rats Open
Obesity is a global public health issue linked to various comorbidities in both humans and animals. This study investigated the effects of vitamin D (VD) and omega-3 fatty acids (ω3FA) on obesity, gut dysbiosis, and metabolic alterations i…
View article: The effects of iron deficient and high iron diets on SARS-CoV-2 lung infection and disease
The effects of iron deficient and high iron diets on SARS-CoV-2 lung infection and disease Open
Introduction The severity of Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is often dictated by a range of comorbidities. A considerable literature suggests iron deficiency a…
View article: Conserved RNA-binding protein interactions mediate syntologous lncRNA functions
Conserved RNA-binding protein interactions mediate syntologous lncRNA functions Open
Syntologous long noncoding RNAs (lncRNAs) are loci with conserved genomic positions that often show little or no sequence similarity. Despite diverging primary sequences, lncRNA syntologs from distant species can carry out similar function…
View article: A getah virus-like-particle vaccine provides complete protection from viremia and arthritis in wild-type mice
A getah virus-like-particle vaccine provides complete protection from viremia and arthritis in wild-type mice Open
Getah virus (GETV) is an emerging mosquito-borne virus with economic impact on the livestock industry in East Asia. In this study, we successfully produced GETV virus-like particles (VLPs) in insect cells using the baculovirus expression v…
View article: The effects of iron deficient and high iron diets on SARS-CoV-2 lung infection and disease
The effects of iron deficient and high iron diets on SARS-CoV-2 lung infection and disease Open
The severity of Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is often dictated by a range of comorbidities. A considerable literature suggests iron deficiency and iron overl…
View article: Microplastics dysregulate innate immunity in the SARS-CoV-2 infected lung
Microplastics dysregulate innate immunity in the SARS-CoV-2 infected lung Open
Introduction Global microplastic (MP) pollution is now well recognized, with humans and animals consuming and inhaling MPs on a daily basis, with a growing body of concern surrounding the potential impacts on human health. Methods Using a …
View article: Characterisation of a Japanese Encephalitis virus genotype 4 isolate from the 2022 Australian outbreak
Characterisation of a Japanese Encephalitis virus genotype 4 isolate from the 2022 Australian outbreak Open
View article: Drug repurposing screen identifies lonafarnib as respiratory syncytial virus fusion protein inhibitor
Drug repurposing screen identifies lonafarnib as respiratory syncytial virus fusion protein inhibitor Open
Respiratory syncytial virus (RSV) is a common cause of acute lower respiratory tract infection in infants, older adults and the immunocompromised. Effective directly acting antivirals are not yet available for clinical use. To address this…
View article: Novel chemical tyrosine functionalization of adeno-associated virus improves gene transfer efficiency in liver and retina
Novel chemical tyrosine functionalization of adeno-associated virus improves gene transfer efficiency in liver and retina Open
View article: Juveniles at Risk: Behaviour and Colour Changes in Sole Juveniles (Solea Solea) after Exposure to Estuarine Ragworms (Hediste Diversicolor) Contaminated with Microplastics
Juveniles at Risk: Behaviour and Colour Changes in Sole Juveniles (Solea Solea) after Exposure to Estuarine Ragworms (Hediste Diversicolor) Contaminated with Microplastics Open
View article: SARS-CoV-2 omicron BA.5 and XBB variants have increased neurotropic potential over BA.1 in K18-hACE2 mice and human brain organoids
SARS-CoV-2 omicron BA.5 and XBB variants have increased neurotropic potential over BA.1 in K18-hACE2 mice and human brain organoids Open
The reduced pathogenicity of the omicron BA.1 sub-lineage compared to earlier variants is well described, although whether such attenuation is retained for later variants like BA.5 and XBB remains controversial. We show that BA.5 and XBB i…
View article: Microplastics dysregulate innate immunity in the SARS-CoV-2 infected lung
Microplastics dysregulate innate immunity in the SARS-CoV-2 infected lung Open
Global microplastic (MP) pollution is now well recognized, with humans and animals consuming and inhaling MPs on a daily basis. Herein we described the effects of azide-free, 1 µm polystyrene MP beads co-delivered into lungs with a SARS-Co…
View article: Inflammatory profile of AAV6 in a pig and human model
Inflammatory profile of AAV6 in a pig and human model Open
View article: Recurrence and survival in dogs with excised colorectal polyps: A retrospective study of 58 cases
Recurrence and survival in dogs with excised colorectal polyps: A retrospective study of 58 cases Open
Background Compared to humans, colorectal polyps are relatively rare in dogs. Epidemiological and prognostic data remain accordingly sparse, although they could help veterinary clinicians in the management of these cases. Objectives To rep…