Explanipedia

Single-nucleus RNA sequencing reveals GABAergic vulnerability and reactive gliosis driven by loss of TDP-43 Open

Rashmi Thapa, Navin Adhikari, Samir Gautam, Mingming Sun, Sierra McOmie , et al. · 2025

Atypical Presentation of Oral Erythema Multiforme - A Case Report Open

Samir Gautam, Senchhema Limbu, Manisha Malla, Parajeeta Dikshit · 2024

Erythema multiforme (EM) is an acute, self-limiting, sometimes recurrent mucocutaneous inflammatory disorder recognized as hypersensitivity reaction primarily triggered by certain infections and drugs. It is often seen as confusing disease…

Does Eosinophil Heterogeneity Translate into Functional Diversity? A Review of the Evolving Paradigm of Eosinophil Heterogeneity in Asthma Open

Gabriella E. Wilson, Samir Gautam, Geoffrey Chupp · 2024

This review provides an overview of evidence supporting the existence of distinct homeostatic and inflammatory eosinophil subpopulations in health and disease. Particular emphasis is placed on describing the phenotypic and functional roles…

Sputum alarmins delineate distinct <span>T2</span> cytokine pathways and unique subtypes of patients with asthma Open

Samir Gautam, J Chu, Avi J. Cohen, Ravdeep Kaur, Seohyuk Lee , et al. · 2023

Differences in Mortality Among Patients With Asthma and COPD Hospitalized With COVID-19 Open

Yunqing Liu, Haseena Rajeevan, Michael Simonov, Seohyuk Lee, F. Perry Wilson , et al. · 2023

Metabolic Syndrome as a Cardiovascular Risk Factor: A Reality or Just a Multiplex of Risk Factors? A Study on Association Between Endothelial Dysfunction And Metabolic Syndrome as a Cardiovascular Risk Factor Open

Mani Prasad Gautam, Samir Gautam, Gangapatnam Subramanyam, Sogunuru Guruprasad · 2023

Background:Metabolic syndrome is a constellation of various cardiovascular risk factors with a potential to double the risk of coronary artery disease. However, in real world scenario, this is just a combination of multiple CV risk factors…

Nonutility of procalcitonin for diagnosing bacterial pneumonia in patients with severe COVID-19 Open

Avi J. Cohen, Laura Glick, Seohyuk Lee, Yukiko Kunitomo, Derek A. Tsang , et al. · 2023

Static measurement of procalcitonin does not aid in the diagnosis of superinfection in severe COVID-19.

Impact of Prophylactic Antibacterials on Coagulation Profiles and Bleeding in Patients with Acute Myeloid Leukemia/Myelodysplastic Syndrome Open

Cecily Allen, Samir Gautam, Wei Cheng, Alexander B. Pine, Nikolai A. Podoltsev , et al. · 2023

Patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) often receive antibacterial prophylaxis. Antibacterial agents can cause elevations in the prothrombin time and international normalized ratio (INR). The impact o…

Coarctation of aorta in a young female with extensive collaterals presenting with secondary hypertension Open

Bishal KC, Sachin Dhungel, Samir Gautam, Mazhar I. Khan, Aziz Ullah · 2022

Coarctation of aorta is a common condition usually diagnosed during childhood. During adulthood they are usually diagnosed during evaluation of secondary hypertension or resistant hypertension. We report a case of young female who was asym…

IFN-<b>γ</b>Is Protective in Cytokine Release Syndrome-associated Extrapulmonary Acute Lung Injury Open

Ying Sun, Buqu Hu, Gail Stanley, Z.M. Harris, Samir Gautam , et al. · 2022

The mechanisms by which excessive systemic activation of adaptive T lymphocytes, as in cytokine release syndrome (CRS), leads to innate immune cell-mediated acute lung injury (ALI) or acute respiratory distress syndrome, often in the absen…

Severe anaphylaxis following administration of radiocontrast in patient undergoing coronary intervention Open

Bishal KC, Samir Gautam, Sachin Dhungel, Mazhar I. Khan, Binesh Shakya · 2022

Radiocontrast material is among the common drugs causing allergic reaction. Mostly it is well tolerated. The symptoms range from mild with urticaria to fatal anaphylaxis, developing rapidly. Anaphylaxis is the most severe form of radiocont…

Sputum alarmin levels delineate distinct T2 cytokine pathways and patient subgroups in asthma Open

Samir Gautam, J Chu, Avi J. Cohen, Ravdeep Kaur, Gabriella Wilson , et al. · 2022

Rationale Asthma is a chronic airway disease driven by multiple immunologic pathways that determine the clinical response to therapy. Current diagnostic methods are incapable of discriminating subtypes of asthma and guiding targeted treatm…

A dual role for CRTH2 in acute lung injury Open

Shreya Bhattacharya, N. Ristic, Avi J. Cohen, Derek A. Tsang, M.S. Gwin , et al. · 2022

Acute respiratory distress syndrome (ARDS) is a life-threatening clinical condition defined by rapid-onset respiratory failure following acute lung injury (ALI). The high mortality rate and rising incidence of ARDS due to COVID-19 make it …

Nonutility of procalcitonin for diagnosing bacterial pneumonia in COVID-19 Open

Avi J. Cohen, Laura Glick, Seohyuk Lee, Yukiko Kunitomo, Derek A. Tsang , et al. · 2022

Patients hospitalized with COVID-19 are at significant risk for superimposed bacterial pneumonia. However, diagnosing superinfection is challenging due to its clinical resemblance to severe COVID-19. We therefore evaluated whether the immu…

Prevalence and treatment of postobstructive pneumonia among older adults with advanced cancer Open

Seohyuk Lee, Lisa O’Donovan, Avi J. Cohen, Samir Gautam, Vincent Quagliarello , et al. · 2022

Among 124 older adults with advanced cancer who were hospitalized with pneumonia, 7.3% met criteria for postobstructive pneumonia. There were no differences in antibiotic duration, antibiotic spectrum, 30-day and 90-day readmissions, or mo…

THE INCIDENCE OF PULMONARY INFECTIONS IN NEUTROPENIC PATIENTS WITH ACTIVE ACUTE MYELOID LEUKEMIA Open

Cecily Allen, Yukiko Kunitomo, Samir Gautam · 2021

Understanding the Host in the Management of Pneumonia. An Official American Thoracic Society Workshop Report Open

Charles S. Dela Cruz, Scott E. Evans, Marcos I. Restrepo, Nathan C. Dean, Antoní Torres , et al. · 2021

Pneumonia causes a significant burden of disease worldwide. Although all populations are at risk of pneumonia, those at extremes of age and those with immunosuppressive disorders, underlying respiratory disease, and critical illness are pa…

Indolent Presentations of Leukemic Lung Disease in Acute Myeloid Leukemia Open

Yukiko Kunitomo, Seohyuk Lee, Chace Avery, Patricia Lasso Toro, Avi J. Cohen , et al. · 2020

Background Patients with active acute myelogenous leukemia (AML) are at risk for leukemic infiltration (LI) into the lung and acute tumor lysis pneumopathy (ATLP) following chemotherapy. Fulminant presentations of these leukemic lung disea…

UNDER-RECOGNITION OF LEUKEMIC LUNG INFILTRATION IN PATIENTS WITH LEUKEMIA AND ACUTE RESPIRATORY ILLNESS Open

Solmaz Ehteshami‐Afshar, Patricia Valda-Toro, Seohyuk Lee, Chace Avery, Avi J. Cohen , et al. · 2020

RADIOGRAPHIC PATTERNS IN PATIENTS WITH LEUKEMIC INFILTRATION Open

Patricia Valda-Toro, Solmaz Ehteshami‐Afshar, Seohyuk Lee, Chace Avery, Avi J. Cohen , et al. · 2020

TEMPERATURE INSTABILITY IN PATIENTS WITH ACUTE MYELOID LEUKEMIA Open

Avi J. Cohen, Solmaz Ehteshami‐Afshar, Derek A. Tsang, Patricia Valda-Toro, Seohyuk Lee , et al. · 2020

A 62-Year-Old Woman With Lung Cancer, Ulcerating Rash, and Rapidly Progressive Hypoxemia Open

Yukiko Kunitomo, Grant M. Young, Rupak Datta, Lisa L. Korn, L.T. Tanoue , et al. · 2020

Severe respiratory viral infection induces procalcitonin in the absence of bacterial pneumonia Open

Samir Gautam, Avi J. Cohen, Yannick Stahl, Patricia Valda Toro, Grant M. Young , et al. · 2020

Introduction Procalcitonin expression is thought to be stimulated by bacteria and suppressed by viruses via interferon signalling. Consequently, during respiratory viral illness, clinicians often interpret elevated procalcitonin as evidenc…

Quantification of bronchoalveolar neutrophil extracellular traps and phagocytosis in murine pneumonia Open

Samir Gautam, Yannick Stahl, Grant M. Young, Rebecca Howell, Avi J. Cohen , et al. · 2020

The past two decades have witnessed a resurgence in neutrophil research, inspired in part by the discovery of neutrophil extracellular traps (NETs) and their myriad roles in health and disease. Within the lung, dysregulation of neutrophils…

Methodology for Studying Neutrophil Extracellular Trap Formation and Phagocytosis in the Murine Lung Open

Grant M. Young, Yannick Stahl, Avi J. Cohen, Carlos Cosme, Samir Gautam , et al. · 2020

Molecular Diagnostics in Pulmonary Infections Open

Catherine A. Gao, John C. Huston, Patricia Valda Toro, Samir Gautam, Charles S. Dela Cruz · 2020

PROCALCITONIN LEVELS IN RESPIRATORY VIRAL INFECTION CORRELATE WITH SEVERITY OF DISEASE Open

Patricia Valda Toro, Grant M. Young, Ragini Luthra, John Huston, Santos Bermejo , et al. · 2019

Prolonged Intubation Induced Tracheoesophageal Fistula in Suspected Meningococcal Sepsis with ARDS: A Case Report Open

Ramesh Rana, Rikesh Sapkota, Binesh Shakya, Samir Gautam · 2018

Tracheoesophageal fistula is an abnormal communication between trachea and esophagus. Benign acquired types are rare with the incidence of less than 1%. Prolonged endotracheal intubation remains the most common cause. We are reporting a 28…

Teaching an Old Intensivist Neutrophil Tricks: Using Alveolar Neutrophilia to Diagnose Ventilator-associated Pneumonia Open

Samir Gautam, Lokesh Sharma, Charles S. Dela Cruz · 2018

A Slick Solution to a Sticky Problem Open

Samir Gautam, Lokesh Sharma, Charles S. Dela Cruz, David A. Spiegel · 2018

ADVERTISEMENT RETURN TO ISSUEPREVViewpointNEXTA Slick Solution to a Sticky ProblemSamir GautamSamir GautamInternal Medicine, Section of Pulmonary and Critical Care, Yale University School of Medicine, 333 Cedar Street, New Haven, Connectic…

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