Samir K. Saha
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View article: Seroresponse to repeated infections with Salmonella enterica Typhi and Paratyphi A
Seroresponse to repeated infections with Salmonella enterica Typhi and Paratyphi A Open
View article: Environmental and maternal imprints on infant gut metabolic development
Environmental and maternal imprints on infant gut metabolic development Open
Early life is a critical period for immune and metabolic development, but these patterns remain underexplored in populations from low- and middle-income countries. Here, we profile the microbiome and metabolome of 55 Bangladeshi mother-inf…
View article: Causes and risk factors for deaths in young infants in South Asia: the ANISA prospective population-based observational cohort study
Causes and risk factors for deaths in young infants in South Asia: the ANISA prospective population-based observational cohort study Open
Introduction Strategies for reducing infant mortality require accurate, local, population-level data. We conducted a population-based observational study in three countries in South Asia to describe risk factors, causes and rates of mortal…
View article: Prevalence of Large‐for‐Gestational Age and Macrosomia Among Livebirths in 23 Low‐ and Middle‐Income Countries Between 2000 and 2021: An Individual Participant Data Analysis
Prevalence of Large‐for‐Gestational Age and Macrosomia Among Livebirths in 23 Low‐ and Middle‐Income Countries Between 2000 and 2021: An Individual Participant Data Analysis Open
Objective To examine the prevalence of large‐for‐gestational age (LGA) and macrosomia in 23 countries between 2000 and 2021. Design Descriptive multi‐country secondary data analysis. Setting Subnational, population‐based cohort studies ( k…
View article: Effect of maternal infection on stillbirths and early neonatal deaths: nested case-control studies in pregnancy cohorts in East Africa
Effect of maternal infection on stillbirths and early neonatal deaths: nested case-control studies in pregnancy cohorts in East Africa Open
Summary Background Reducing perinatal deaths is a priority, but data on maternal infectious causes are sparse in low- and middle-income countries where the burden is highest. We aimed to describe maternal infections at delivery and their a…
View article: Environmental and Maternal Imprints on Infant Gut Metabolic Programming
Environmental and Maternal Imprints on Infant Gut Metabolic Programming Open
Early life is a critical period for immune and metabolic programming, but developmental patterns remain underexplored in populations from low- and middle-income countries. Here, we profiled the microbiome and metabolome of 55 Bangladeshi m…
View article: Incidence and epidemiology of Respiratory Syncytial Virus infections in children in rural Bangladesh: a prospective observational study
Incidence and epidemiology of Respiratory Syncytial Virus infections in children in rural Bangladesh: a prospective observational study Open
Background Respiratory syncytial virus (RSV) is a leading cause of acute respiratory infection (ARI) in young children worldwide, yet data from low- and middle-income countries (LMICs) are scarce. The data that are available are mostly hos…
View article: Cohort Profile: Health and Demographic Surveillance System in Mirzapur, Tangail, Bangladesh
Cohort Profile: Health and Demographic Surveillance System in Mirzapur, Tangail, Bangladesh Open
The Mirzapur Health and Demographic Surveillance System (MHDSS), established in 2007 in Tangail, Bangladesh, systematically monitors population and health dynamics across 10 unions, covering 316,628 individuals as of 2022. It collects long…
View article: Severe infection incidence among young infants in Dhaka, Bangladesh: an observational cohort study
Severe infection incidence among young infants in Dhaka, Bangladesh: an observational cohort study Open
Introduction Heterogeneity in definitions of severe infection, sepsis and serious bacterial infection (SBI) in infants limits the comparability of randomised controlled trials (RCTs) of infection prevention interventions. To inform the des…
View article: Distribution of capsule and O types in Klebsiella pneumoniae causing neonatal sepsis in Africa and South Asia: meta-analysis of genome-predicted serotype prevalence to inform potential vaccine coverage
Distribution of capsule and O types in Klebsiella pneumoniae causing neonatal sepsis in Africa and South Asia: meta-analysis of genome-predicted serotype prevalence to inform potential vaccine coverage Open
Background: Klebsiella pneumoniae causes ~20% of sepsis in neonates, with ~40% crude mortality. A vaccine administered to pregnant women, protecting against 70% of K. pneumoniae infections, could avert ~400,000 cases and ~80,000 deaths ann…
View article: Outbreak of Ceftriaxone-Resistant <i>Salmonella enterica</i> Serovar Typhi, Bangladesh, 2024
Outbreak of Ceftriaxone-Resistant <i>Salmonella enterica</i> Serovar Typhi, Bangladesh, 2024 Open
We report an outbreak of ceftriaxone-resistant Salmonella enterica serovar Typhi in Bangladesh; 47 cases were identified during April-September 2024. Isolates belonged to genotype 4.3.1.2 and harbored the blaCTX-M-15 gene on the…
View article: Evaluating the accuracy of<i>Salmonella</i>Typhi Hemolysin E and lipopolysaccharide IgA to discriminate enteric fever from other febrile illnesses in South Asia
Evaluating the accuracy of<i>Salmonella</i>Typhi Hemolysin E and lipopolysaccharide IgA to discriminate enteric fever from other febrile illnesses in South Asia Open
Existing methods to identify patients infected with Salmonella enterica Typhi (S. Typhi) or Paratyphi are inadequately accurate, affordable, and efficient. We evaluated the discriminatory power of antibodies to S. Typhi hemolysin E (HlyE) …
View article: Escalating carbapenem-resistant Klebsiella burden and mortality in Bangladeshi infants
Escalating carbapenem-resistant Klebsiella burden and mortality in Bangladeshi infants Open
Klebsiella infections in young infants are an escalating threat in low- and middle-income countries, yet robust hospital burden and antimicrobial-resistance data informed by genomics remain scarce. We performed an 18-year (2004-2021) prosp…
View article: serocalculator, an R package for estimating seroincidence from cross-sectional serological data
serocalculator, an R package for estimating seroincidence from cross-sectional serological data Open
Motivation: Seroincidence—the rate of new infections in a population—is a key measure for understanding pathogen transmission dynamics and informing public health action. Estimating seroincidence from cross-sectional data is complicated by…
View article: Mortality risk associated with clinical signs of possible serious bacterial infection (PSBI) in young infants in Africa and Asia: protocol for a secondary pooled analysis
Mortality risk associated with clinical signs of possible serious bacterial infection (PSBI) in young infants in Africa and Asia: protocol for a secondary pooled analysis Open
Introduction The WHO’s Integrated Management of Childhood Illness (IMCI) in young infants <2 months of age includes the identification and management of signs of possible serious bacterial infection (PSBI). However, equal importance is giv…
View article: Health-care burden related to respiratory syncytial virus in a resource-constrained setting: a prospective observational study
Health-care burden related to respiratory syncytial virus in a resource-constrained setting: a prospective observational study Open
The Bill & Melinda Gates Foundation.
View article: Effects of Early Neonatal Administration of Lactiplantibacillus plantarum ATCC 202195 on the Fecal Microbiota of Infants in Dhaka, Bangladesh
Effects of Early Neonatal Administration of Lactiplantibacillus plantarum ATCC 202195 on the Fecal Microbiota of Infants in Dhaka, Bangladesh Open
View article: Changes in enteric fever trends during the COVID-19 pandemic from the Surveillance for Enteric Fever in Asia Project: a cross-sectional study
Changes in enteric fever trends during the COVID-19 pandemic from the Surveillance for Enteric Fever in Asia Project: a cross-sectional study Open
View article: Effects of Malathion Organophosphate Exposure on Histology of Salivary Glands of 3rd Instar Larva and Brain of Adult Common Fruit Fly (Drosophila melanogaster)
Effects of Malathion Organophosphate Exposure on Histology of Salivary Glands of 3rd Instar Larva and Brain of Adult Common Fruit Fly (Drosophila melanogaster) Open
Malathion is a common organophosphate insecticide globally used in agriculture. Previous studies show that exposure to malathion causes considerable decrease in levels of amylase and acetylcholinesterase in Drosophila, which has a crucial …
View article: Neonatal administration of <i>Lactiplantibacillus plantarum</i> ATCC 202195 with or without fructooligosaccharide in Bangladesh: a placebo-controlled randomized trial
Neonatal administration of <i>Lactiplantibacillus plantarum</i> ATCC 202195 with or without fructooligosaccharide in Bangladesh: a placebo-controlled randomized trial Open
Lactiplantibacillus plantarum ATCC 202195 (LP202195) plus fructooligosaccharide (FOS) for 7 days was previously shown to colonize the infant intestine up to 6 months of age and reduced sepsis rates among young infants in rural India. In a …
View article: Association of clinical signs of possible serious bacterial infections identified by community health workers with mortality of young infants in South Asia: a prospective, observational cohort study
Association of clinical signs of possible serious bacterial infections identified by community health workers with mortality of young infants in South Asia: a prospective, observational cohort study Open
View article: Genome sequences of bacteriophages that infect <i>Salmonella</i> Typhi from Bangladesh
Genome sequences of bacteriophages that infect <i>Salmonella</i> Typhi from Bangladesh Open
This report presents near-complete genome sequences of 14 bacteriophages that infect Salmonella Typhi, identified through environmental surveillance in Bangladesh between August 2021 and June 2022. The bacteriophages, belonging to the gene…
View article: Evaluation of a point-of-care immunochromatographic assay for enteric fever in Dhaka, Bangladesh: a prospective diagnostic accuracy study
Evaluation of a point-of-care immunochromatographic assay for enteric fever in Dhaka, Bangladesh: a prospective diagnostic accuracy study Open
National Institute of Health, Bill & Melinda Gates Foundation, and Child Health Research Foundation.
View article: Diversity in Naturally Acquired Immunity to Group B Streptococcus: A Comparative Study of Women From Bangladesh, Malawi, and the United Kingdom
Diversity in Naturally Acquired Immunity to Group B Streptococcus: A Comparative Study of Women From Bangladesh, Malawi, and the United Kingdom Open
Background Significant disparities in group B Streptococcus (GBS) colonization and neonatal disease rates have been documented across different geographic regions. For example, Bangladesh reports notably lower rates as compared with the Un…
View article: Viral Acute Lower Respiratory Tract Infections (ALRI) in Rural Bangladeshi Children Prior to the COVID‐19 Pandemic
Viral Acute Lower Respiratory Tract Infections (ALRI) in Rural Bangladeshi Children Prior to the COVID‐19 Pandemic Open
Background Acute lower respiratory tract infections (ALRIs) remain the leading infectious cause of death among children < 5 years, with viruses contributing to a large proportion of cases. Little is known about the epidemiology and etiolog…
View article: Embryotoxicity of Cypermethrin, a Synthetic Pyrethroid Insecticide in Zebrafish
Embryotoxicity of Cypermethrin, a Synthetic Pyrethroid Insecticide in Zebrafish Open
View article: Trends in antimicrobial resistance amongst Salmonella Typhi in Bangladesh: A 24-year retrospective observational study (1999–2022)
Trends in antimicrobial resistance amongst Salmonella Typhi in Bangladesh: A 24-year retrospective observational study (1999–2022) Open
Background Rising antimicrobial resistance (AMR) in Salmonella Typhi restricts typhoid treatment options, heightening concerns for pan-oral drug-resistant outbreaks. However, lack of long-term temporal surveillance data on AMR in countries…
View article: Severe infection among young infants in Dhaka, Bangladesh: effect of case definition on incidence estimates
Severe infection among young infants in Dhaka, Bangladesh: effect of case definition on incidence estimates Open
Introduction Heterogeneity in definitions of severe infection, sepsis and serious bacterial infection (SBI) in young infants limits the comparability of randomized controlled trials (RCTs) of infection prevention interventions. To inform t…
View article: Impact of 10-valent pneumococcal conjugate vaccine on the epidemiology of otitis media with otorrhea among Bangladeshi children
Impact of 10-valent pneumococcal conjugate vaccine on the epidemiology of otitis media with otorrhea among Bangladeshi children Open
In 2015, Bangladesh introduced the ten-valent pneumococcal conjugate vaccine (PCV10). This study evaluates the impact of PCV10 on pneumococcal otitis media (OM), a prevalent middle ear infection amongst children in low-and-middle income co…
View article: Prevalence of group B Streptococcus colonisation in mother–newborn dyads in low-income and middle-income south Asian and African countries: a prospective, observational study
Prevalence of group B Streptococcus colonisation in mother–newborn dyads in low-income and middle-income south Asian and African countries: a prospective, observational study Open
Bill & Melinda Gates Foundation.