Samir Kumar‐Singh
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View article: A comprehensive longitudinal analysis of the cellular immune response specific to the spike protein in healthcare workers vaccinated against SARS-CoV-2– ORCHESTRA Project
A comprehensive longitudinal analysis of the cellular immune response specific to the spike protein in healthcare workers vaccinated against SARS-CoV-2– ORCHESTRA Project Open
Introduction The long-term dynamics of T-cell immunity following SARS-CoV-2 vaccination, essential for durable protection, remain incompletely understood. This study, therefore, aimed to investigate the kinetics and persistence of spike-sp…
View article: The Risk Factors for Complications Following Intestinal Stoma Reversal
The Risk Factors for Complications Following Intestinal Stoma Reversal Open
View article: Persistent Spike antigenemia is not associated with Post-COVID condition
Persistent Spike antigenemia is not associated with Post-COVID condition Open
A bstract Objectives Spike antigenemia has been proposed as one of the potential mechanisms underlying post-COVID condition (PCC). Several studies addressing Spike antigenemia have measured both free and antibody-bound Spike employing 10 m…
View article: <i>Lacticaseibacillus rhamnosus</i> GG in a chewable colonizes the nose and facilitates local immune benefits in allergic rhinoconjunctivitis patients
<i>Lacticaseibacillus rhamnosus</i> GG in a chewable colonizes the nose and facilitates local immune benefits in allergic rhinoconjunctivitis patients Open
Current treatments fall short in managing allergic rhinitis (AR), emphasizing the need for additional strategies. Beneficial bacteria application shows promise in AR; however, most studies focus on oral probiotic administration without mon…
View article: Drivers of quasispecies development in SARS-CoV-2 and implications for emergent variants and COVID-19
Drivers of quasispecies development in SARS-CoV-2 and implications for emergent variants and COVID-19 Open
Since the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 2019, significant research has focused on SARS-CoV-2 evolution and transmission. Most transmission studies rely on RT-qPCR and consensus sequencing for …
View article: Aquaporin 4 modulation drives amyloid burden and cognitive abilities in an APPPS1 mouse model of Alzheimer's disease
Aquaporin 4 modulation drives amyloid burden and cognitive abilities in an APPPS1 mouse model of Alzheimer's disease Open
INTRODUCTION Deficiency in the aquaporin‐4 (AQP4) water channel has been linked to impaired amyloid beta (Aβ) clearance. However, a detailed morphopathological analysis of amyloid deposition following AQP4 therapeutic modulation remains un…
View article: Quasi-species prevalence and clinical impact of evolving SARS-CoV-2 lineages in European COVID-19 cohorts, January 2020 to February 2022
Quasi-species prevalence and clinical impact of evolving SARS-CoV-2 lineages in European COVID-19 cohorts, January 2020 to February 2022 Open
Background Evolution of SARS-CoV-2 is continuous. Aim Between 01/2020 and 02/2022, we studied SARS-CoV-2 variant epidemiology, evolution and association with COVID-19 severity. Methods In nasopharyngeal swabs of COVID-19 patients (n = 1,76…
View article: Addition of Modified Lemaire Lateral Extra-Articular Tenodesis in a Single stage Revision Anterior Cruciate Ligament Reconstruction using Peroneus Longus Tendon: A Prospective Study
Addition of Modified Lemaire Lateral Extra-Articular Tenodesis in a Single stage Revision Anterior Cruciate Ligament Reconstruction using Peroneus Longus Tendon: A Prospective Study Open
Single-stage revision ACLR using PLT with an additional modified Lemaire LET procedure results in a significant reduction in residual knee laxity with good clinical outcomes and a high return to play and physical activity.
View article: Generation of a T cell receptor, cytokine and cell repertoire synovial fluid atlas to define commonalities and dissimilarities between arthritic diseases through systems immunology approaches
Generation of a T cell receptor, cytokine and cell repertoire synovial fluid atlas to define commonalities and dissimilarities between arthritic diseases through systems immunology approaches Open
Although different chronic arthritic diseases are defined by clinical factors like gender, psoriasis and auto-antibodies, the biology of inflamed joints while comparing the different diseases remains neglected. Here, after curating an infl…
View article: Protocol for fecal microbiota transplantation: A microaerophilic approach for mice housed in a specific pathogen-free facility
Protocol for fecal microbiota transplantation: A microaerophilic approach for mice housed in a specific pathogen-free facility Open
View article: COMPARATIVE EVALUATION OF P16, P53, AND KI-67 EXPRESSION IN CERVICAL INTRAEPITHELIAL NEOPLASIA AND INVASIVE CERVICAL CARCINOMA: A PROSPECTIVE HISTOPATHOLOGICAL AND IMMUNOHISTOCHEMICAL STUDY
COMPARATIVE EVALUATION OF P16, P53, AND KI-67 EXPRESSION IN CERVICAL INTRAEPITHELIAL NEOPLASIA AND INVASIVE CERVICAL CARCINOMA: A PROSPECTIVE HISTOPATHOLOGICAL AND IMMUNOHISTOCHEMICAL STUDY Open
Introduction: Cervical cancer remains a leading cause of cancer-related mortality among women worldwide, particularly in developing countries. Persistent infection with high-risk human papillomavirus types, mainly 16 and 18, plays a pivota…
View article: Immunogenicity, Reactogenicity and Safety to Assess Booster Vaccinations with BNT162b2 or Full-Dose mRNA-1273 in Adults ≥75 Years (EU-COVAT-1-AGED) – Final Report
Immunogenicity, Reactogenicity and Safety to Assess Booster Vaccinations with BNT162b2 or Full-Dose mRNA-1273 in Adults ≥75 Years (EU-COVAT-1-AGED) – Final Report Open
View article: Tracing carriage, acquisition, and transmission of ESBL-producing Escherichia coli over two years in a tertiary care hospital
Tracing carriage, acquisition, and transmission of ESBL-producing Escherichia coli over two years in a tertiary care hospital Open
Our data show a high prevalence of nosocomial acquisition of ESBL-E in a non-ICU setting. The study provides genomic evidence that the endogenous reservoir is the main driver of ESBL-Ec infections underscoring the need for wide implementat…
View article: <i>Lacticaseibacillus rhamnosus</i>GG in a chewable colonizes the nose and facilitates local immune benefits in allergic rhinoconjunctivitis patients
<i>Lacticaseibacillus rhamnosus</i>GG in a chewable colonizes the nose and facilitates local immune benefits in allergic rhinoconjunctivitis patients Open
Current treatments fall short in managing allergic rhinitis (AR), emphasizing the need for additional strategies. Beneficial bacteria application shows promise in AR, however most studies focus on oral probiotic administration without moni…
View article: Chemosensory assessment and impact on quality of life in neurosensorial cluster of the post COVID 19 syndrome
Chemosensory assessment and impact on quality of life in neurosensorial cluster of the post COVID 19 syndrome Open
COVID-19 pandemic brought chemosensory impairment to the forefront of medicine, revealing gaps in the knowledge of pathophysiological mechanisms, true prevalence and preventive/therapeutic alternatives. This is a sub-study of the ORCHESTRA…
View article: Interleukin‐2‐mediated CD4 T‐cell activation correlates highly with effective serological and T‐cell responses to SARS‐CoV‐2 vaccination in people living with HIV
Interleukin‐2‐mediated CD4 T‐cell activation correlates highly with effective serological and T‐cell responses to SARS‐CoV‐2 vaccination in people living with HIV Open
People living with HIV (PLWH) despite having an appreciable depletion of CD4 + T‐cells show a good severe acute respiratory syndrome coronavirus 2 vaccination response. The underlying mechanism(s) are currently not understood. We studied s…
View article: Immunogenicity, reactogenicity, and safety of a second booster with BNT162b2 or full-dose mRNA-1273: A randomized VACCELERATE trial in adults aged ≥75 years (EU-COVAT-1-AGED Part B)
Immunogenicity, reactogenicity, and safety of a second booster with BNT162b2 or full-dose mRNA-1273: A randomized VACCELERATE trial in adults aged ≥75 years (EU-COVAT-1-AGED Part B) Open
A second booster of either BNT162b2 or mRNA-1273 provided substantial IgG increase. Full-dose mRNA-1273 provided higher IgG levels and neutralizing capacity against SARS-CoV-2, with similar safety profile for subjects of advanced age.
View article: IL-2-mediated CD4 T-cell activation correlates highly with effective serological and T-cell responses to SARS-CoV-2 vaccination in people living with HIV (PLWH)
IL-2-mediated CD4 T-cell activation correlates highly with effective serological and T-cell responses to SARS-CoV-2 vaccination in people living with HIV (PLWH) Open
People living with HIV (PLWH) despite having appreciable depletion of CD4 + T-cell show a good SARS- CoV-2 vaccination response. The underlying mechanism(s) are currently not understood. We studied serological and polyfunctional T-cell res…
View article: The natural history of CVB3 myocarditis in C57BL/6J mice: an extended in-depth characterization
The natural history of CVB3 myocarditis in C57BL/6J mice: an extended in-depth characterization Open
CVB inoculation in C57BL/6J mice represents a model of acute self-limiting viral myocarditis, with progression to different patterns of myocardial fibrosis. Sex, but not inoculation dose, seems to modulate the course of disease.
View article: Frequent host-switch and gene exchange shape the evolution of Staphylococcus aureus ST398
Frequent host-switch and gene exchange shape the evolution of Staphylococcus aureus ST398 Open
Staphylococcus aureus ST398 is a typical ‘One Health’ pathobiont exemplifying multiple-host tropisms. Here we traced the evolutionary trajectory of the global accessory genome (an assembly of accessory genes) of S. aureus ST398 over 20 yea…
View article: Mrgprb2-dependent Mast Cell Activation Plays a Crucial Role in Acute Colitis
Mrgprb2-dependent Mast Cell Activation Plays a Crucial Role in Acute Colitis Open
View article: 2383. Immunogenicity and reactogenicity of a first booster with BNT162b2 or full-dose mRNA-1273: a randomised trial in adults ≥75 years (EU-COVAT-1) from the VACCELERATE consortium
2383. Immunogenicity and reactogenicity of a first booster with BNT162b2 or full-dose mRNA-1273: a randomised trial in adults ≥75 years (EU-COVAT-1) from the VACCELERATE consortium Open
Background Vaccination remains crucial for protection against severe SARS-CoV-2 infection, especially in aged population. Methods We evaluated, with a randomised controlled, adaptive, multicentre phase II study, the safety and immunogenici…
View article: Dissecting the role of the gut microbiome and fecal microbiota transplantation in radio- and immunotherapy treatment of colorectal cancer
Dissecting the role of the gut microbiome and fecal microbiota transplantation in radio- and immunotherapy treatment of colorectal cancer Open
Colorectal cancer (CRC) is one of the most commonly diagnosed cancers and poses a major burden on the human health worldwide. At the moment, treatment of CRC consists of surgery in combination with (neo)adjuvant chemotherapy and/or radioth…
View article: High sera levels of SARS‐CoV‐2 N antigen are associated with death in hospitalized COVID‐19 patients
High sera levels of SARS‐CoV‐2 N antigen are associated with death in hospitalized COVID‐19 patients Open
The presence of free severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) nucleocapsid‐antigen in sera (N‐antigenemia) has been shown in COVID‐19 patients. However, the link between the quantitative levels of N‐antigenemia and COVI…
View article: Immunogenicity and reactogenicity of a first booster with BNT162b2 or full-dose mRNA-1273: A randomised VACCELERATE trial in adults ≥75 years (EU-COVAT-1)
Immunogenicity and reactogenicity of a first booster with BNT162b2 or full-dose mRNA-1273: A randomised VACCELERATE trial in adults ≥75 years (EU-COVAT-1) Open
This trial was funded by the European Commission (Framework Program HORIZON 2020).
View article: IMUNOGENICIDADE DE UM PRIMEIRO REFORÇO COM BNT162B2 OU MRNA-1273 DE DOSE COMPLETA: UM ESTUDO RANDOMIZADO EM ADULTOS ≥75 ANOS (EU-COVAT-1) DO CONSÓRCIO VACCELERATE
IMUNOGENICIDADE DE UM PRIMEIRO REFORÇO COM BNT162B2 OU MRNA-1273 DE DOSE COMPLETA: UM ESTUDO RANDOMIZADO EM ADULTOS ≥75 ANOS (EU-COVAT-1) DO CONSÓRCIO VACCELERATE Open
Introdução: A vacinação continua sendo crucial para a proteção contra a infecção grave pelo SARS-CoV-2, especialmente na população idosa. Métodos: Avaliamos, em um estudo de fase II randomizado, controlado, adaptativo e multicêntrico, a se…
View article: Clinical phenotypes and quality of life to define post-COVID-19 syndrome: a cluster analysis of the multinational, prospective ORCHESTRA cohort
Clinical phenotypes and quality of life to define post-COVID-19 syndrome: a cluster analysis of the multinational, prospective ORCHESTRA cohort Open
View article: Using machine learning to predict antibody response to SARS-CoV-2 vaccination in solid organ transplant recipients: the multicentre ORCHESTRA cohort
Using machine learning to predict antibody response to SARS-CoV-2 vaccination in solid organ transplant recipients: the multicentre ORCHESTRA cohort Open
View article: Host immunological responses facilitate development of SARS-CoV-2 mutations in patients receiving monoclonal antibody treatments
Host immunological responses facilitate development of SARS-CoV-2 mutations in patients receiving monoclonal antibody treatments Open
BackgroundThe role of host immunity in emergence of evasive SARS-CoV-2 Spike mutations under therapeutic monoclonal antibody (mAb) pressure remains to be explored.MethodsIn a prospective, observational, monocentric ORCHESTRA cohort study, …
View article: Immunogenicity and Reactogenicity of a First Booster with NT162b2or Full-Dose mRNA-1273: A Randomised VACCELERATE Trial in Adults ≥75 Years (EU-COVAT-1)
Immunogenicity and Reactogenicity of a First Booster with NT162b2or Full-Dose mRNA-1273: A Randomised VACCELERATE Trial in Adults ≥75 Years (EU-COVAT-1) Open