Samir Patel
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View article: A case of the blue blues: the safety issue of recognizing and avoiding the retinal toxicity of methylene blue compared to brilliant blue and trypan blue
A case of the blue blues: the safety issue of recognizing and avoiding the retinal toxicity of methylene blue compared to brilliant blue and trypan blue Open
View article: Hemophagocytic Lymphohistiocytosis Associated With Disseminated Histoplasmosis in a Patient With Chronic Pancytopenia: A Rare Case
Hemophagocytic Lymphohistiocytosis Associated With Disseminated Histoplasmosis in a Patient With Chronic Pancytopenia: A Rare Case Open
View article: Comparing Rhegmatogenous and Tractional Retinal Detachment in Regressed Retinopathy of Prematurity: An International, Multicenter Study
Comparing Rhegmatogenous and Tractional Retinal Detachment in Regressed Retinopathy of Prematurity: An International, Multicenter Study Open
View article: Ultra-early Gamma Knife stereotactic radiosurgery for trigeminal neuralgia (URGEnt-TN): Feasibility and potential benefit: study protocol for a single-centre, two-arm, parallel group design, pragmatic, noninferiority, phase II, randomized controlled trial with intention-to-treat analysis for pre-refractory GK-SRS in classical or idiopathic TN
Ultra-early Gamma Knife stereotactic radiosurgery for trigeminal neuralgia (URGEnt-TN): Feasibility and potential benefit: study protocol for a single-centre, two-arm, parallel group design, pragmatic, noninferiority, phase II, randomized controlled trial with intention-to-treat analysis for pre-refractory GK-SRS in classical or idiopathic TN Open
Background: Trigeminal neuralgia (TN) is a chronic, often debilitating neuropathic facial pain condition. First-line treatment is medical therapy, with carbamazepine being the gold standard. Surgery, including stereotactic radiosurgery in …
View article: The Role of Phosphodiesterase-5 Enzyme Inhibitors and Prostacyclin Analogs in Reactive Pulmonary Vasculopathy in Systolic Heart Failure: A Narrative Review
The Role of Phosphodiesterase-5 Enzyme Inhibitors and Prostacyclin Analogs in Reactive Pulmonary Vasculopathy in Systolic Heart Failure: A Narrative Review Open
View article: Erratum to “An Analysis of Solicitations From Predatory Journals in Ophthalmology,” Am J Ophthalmol 2024; 264:216-223
Erratum to “An Analysis of Solicitations From Predatory Journals in Ophthalmology,” Am J Ophthalmol 2024; 264:216-223 Open
View article: Risk of infection in patients with early inflammatory arthritis: results from a large UK prospective observational cohort study
Risk of infection in patients with early inflammatory arthritis: results from a large UK prospective observational cohort study Open
Objective To identify risk of serious infections (SI) according to initial conventional synthetic DMARDs (csDMARD) and CS, in patients recruited to the National Early Inflammatory Arthritis Audit. Methods An observational cohort study was …
View article: The Burden of Antimicrobial Resistant Bacteremia in Ontario: A Population-Wide Analysis of Attributable Mortality From 110 Pathogen-Antibiotic Combinations
The Burden of Antimicrobial Resistant Bacteremia in Ontario: A Population-Wide Analysis of Attributable Mortality From 110 Pathogen-Antibiotic Combinations Open
Background Reliable information on the burden of antimicrobial resistance (AMR) is necessary to confront the threat of antimicrobial resistance. We sought to examine the association between AMR and mortality across cultured bacterial blood…
View article: Erratum to “An Analysis of Solicitations From Predatory Journals in Ophthalmology,” Am J Ophthalmol 2024; 264:216–223
Erratum to “An Analysis of Solicitations From Predatory Journals in Ophthalmology,” Am J Ophthalmol 2024; 264:216–223 Open
View article: Spectrophotometric Simultaneous Equation and Area under the Curve Methods for Estimation of Metoprolol Succinate and Telmisartan in Pure Drugs and its Combined Marketed Formulation
Spectrophotometric Simultaneous Equation and Area under the Curve Methods for Estimation of Metoprolol Succinate and Telmisartan in Pure Drugs and its Combined Marketed Formulation Open
View article: Comparative Evaluation of Protecting Affordability of Flexible Laminates to <i>Bacopa momnnieri</i> Powder Extract
Comparative Evaluation of Protecting Affordability of Flexible Laminates to <i>Bacopa momnnieri</i> Powder Extract Open
Background: Bacopa monnieri, a medicinal herb, is widely used for its cognitive-enhancing properties. The stability of its active component, Bacoside-A, in commercially available formulations, is influenced by packaging materials. High-Per…
View article: P004 Temporal and regional variation in the initiation of biologic and targeted synthetic DMARDs for rheumatoid arthritis: a nationwide cohort study
P004 Temporal and regional variation in the initiation of biologic and targeted synthetic DMARDs for rheumatoid arthritis: a nationwide cohort study Open
Background/Aims For people who have active rheumatoid arthritis (RA) despite treatment with conventional synthetic DMARDs, timely escalation to biologic and targeted synthetic DMARDs (b/tsDMARDs) improves outcomes and prevents morbidity. I…
View article: A Novel Approach for the Simultaneous Determination of Hecogenin and Stigmasterol in <i>Chlorophytum borivilianum</i> Extract Using High-Performance Liquid Chromatography
A Novel Approach for the Simultaneous Determination of Hecogenin and Stigmasterol in <i>Chlorophytum borivilianum</i> Extract Using High-Performance Liquid Chromatography Open
Background: A reliable technique to determine stigmasterol and hecogenin simultaneously in Chlorophytum borivilianum root extract is essential for their analysis in pharmaceutical formulations. Aim: To establish and validate a High-Perform…
View article: Delayed presentation of superficial femoral artery rupture: A case report
Delayed presentation of superficial femoral artery rupture: A case report Open
View article: Factors associated with biological and targeted synthetic disease-modifying antirheumatic drug initiation for rheumatoid arthritis in underserved patient groups in England and Wales, UK: a national cohort study
Factors associated with biological and targeted synthetic disease-modifying antirheumatic drug initiation for rheumatoid arthritis in underserved patient groups in England and Wales, UK: a national cohort study Open
Sandoz UK.
View article: Temporal and regional variation in the use of biologic and targeted synthetic DMARDs for rheumatoid arthritis: a nationwide cohort study
Temporal and regional variation in the use of biologic and targeted synthetic DMARDs for rheumatoid arthritis: a nationwide cohort study Open
Objective The objective of this study was to evaluate temporal and regional variation in biologic and targeted synthetic DMARD (b/tsDMARD) initiation for RA in England and Wales. Methods An observational cohort study was conducted for peop…
View article: Effects of Loss-to-Follow-Up on Functional and Anatomic Outcomes in Patients with Neovascular Age-Related Macular Degeneration
Effects of Loss-to-Follow-Up on Functional and Anatomic Outcomes in Patients with Neovascular Age-Related Macular Degeneration Open
Purpose: To study the effect of loss-to-follow-up (LTFU) in patients receiving anti-vascular endothelial growth factor (VEGF) injections for neovascular age-related macular degeneration (nAMD). Patients and Methods: Retrospective, multi-ce…
View article: Genomic Epidemiology of Large Blastomycosis Outbreak, Ontario, Canada, 2021
Genomic Epidemiology of Large Blastomycosis Outbreak, Ontario, Canada, 2021 Open
Using phylogenomic analysis, we provide genomic epidemiology analysis of a large blastomycosis outbreak in Ontario, Canada, caused by Blastomyces gilchristii. The outbreak occurred in a locale where blastomycosis is rarely diagnosed, signa…
View article: OA20 Serious infections hospital admissions and mortality in patients with early inflammatory arthritis: results from the National Early Inflammatory Arthritis Audit
OA20 Serious infections hospital admissions and mortality in patients with early inflammatory arthritis: results from the National Early Inflammatory Arthritis Audit Open
Background/Aims To identify the risk of serious infections (SI) according to initial treatment strategy, using conventional synthetic disease modifying anti-rheumatic drugs (csDMARD) and corticosteroids, in patients recruited to the Nation…
View article: An Analysis of Solicitations From Predatory Journals in Ophthalmology
An Analysis of Solicitations From Predatory Journals in Ophthalmology Open
View article: Erratum for McTaggart et al., “First Canadian report of transmission of fluconazole-resistant <i>Candida parapsilosis</i> within two hospital networks confirmed by genomic analysis”
Erratum for McTaggart et al., “First Canadian report of transmission of fluconazole-resistant <i>Candida parapsilosis</i> within two hospital networks confirmed by genomic analysis” Open
Volume 62, no. 1, e01161-23, 2024, https://doi.org/10.1128/jcm.01161-23. The first two sentences of the legend of Fig. 2 should be replaced with the following: "(A) Phylogenomic analysis of whole genome SNVs of C. parapsilosis by MycoSNP a…
View article: No Waning of Pneumococcal Vaccine Responses over Time in People with Inflammatory Arthritis: Findings from a Single Centre Cohort
No Waning of Pneumococcal Vaccine Responses over Time in People with Inflammatory Arthritis: Findings from a Single Centre Cohort Open
Background: Vaccination against pneumococcus reduces the risk of infective events, hospitalisation, and death in individual with inflammatory arthritis, particularly in those on immunomodulating therapy who are at risk of worse outcomes fr…
View article: A Systematic Review and Meta-Analysis of Anti-Rheumatic Drugs and Pneumococcal Vaccine Immunogenicity in Inflammatory Arthritis
A Systematic Review and Meta-Analysis of Anti-Rheumatic Drugs and Pneumococcal Vaccine Immunogenicity in Inflammatory Arthritis Open
Background: Pneumococcal pneumonia is an important cause of morbidity and mortality amongst patients with inflammatory arthritis. Vaccination is recommended by the National Institute for Health and Care Excellence (NICE) but it remains unc…
View article: QUANTIFYING HEAD POSITION AFTER VITRECTOMY USING A THREE-DIMENSIONAL POSITION SENSOR EMBEDDED IN A NOVEL OPHTHALMIC SHIELD: A PILOT STUDY
QUANTIFYING HEAD POSITION AFTER VITRECTOMY USING A THREE-DIMENSIONAL POSITION SENSOR EMBEDDED IN A NOVEL OPHTHALMIC SHIELD: A PILOT STUDY Open
Purpose: To assess head position after pars plana vitrectomy using a novel low-energy, nonintrusive three-dimensional position sensor platform. Methods: In this prospective nonrandomized interventional case series, a low-energy Bluetooth s…
View article: High-throughput method to analyze the cytotoxicity of CAR T Cells in a 3D tumor spheroid model using image cytometry
High-throughput method to analyze the cytotoxicity of CAR T Cells in a 3D tumor spheroid model using image cytometry Open
Chimeric antigen receptor (CAR)-T cell therapy is an antigen-dependent cellular therapy that has gained considerable traction in the field of cancer immunotherapy. Currently, there are six FDA-approved CAR-T cell therapies, which all targe…
View article: Characterization and comparison of acridine orange/propidium iodide and acridine/DAPI viability detection methods for cell and gene therapy development
Characterization and comparison of acridine orange/propidium iodide and acridine/DAPI viability detection methods for cell and gene therapy development Open
Cell viability is one of the critical quality attributes (CQAs) for analyzing and characterizing cellular therapeutic products. The characterization of cell viability is essential to ensure quality, safety and efficacy during cell and gene…
View article: Long-Term Toxicities among Wilms Tumor Survivors
Long-Term Toxicities among Wilms Tumor Survivors Open
Successive trials conducted by the National Wilms Tumor Study have resulted in very high cure rates for children with Wilms tumor (WT). These trials have also significantly reduced the indications for doxorubicin and higher doses of RT in …
View article: Comparing the transmission potential from sequence and surveillance data of 2009 North American influenza pandemic waves
Comparing the transmission potential from sequence and surveillance data of 2009 North American influenza pandemic waves Open
Technological advancements in phylodynamic modeling coupled with the accessibility of real-time pathogen genetic data are increasingly important for understanding the infectious disease transmission dynamics. In this study, we compare the …
View article: High-throughput method to analyze the cytotoxicity of CAR-T Cells in a 3D tumor spheroid model using image cytometry
High-throughput method to analyze the cytotoxicity of CAR-T Cells in a 3D tumor spheroid model using image cytometry Open
Solid tumors account for approximately 90% of all adult human cancers. As such, the development of novel cellular therapies has become of increasing importance to target solid tumor malignancies, such as prostate, lung, breast, bladder, co…
View article: Point-of-Care Ultrasound Use in Nephrology: A Survey of Nephrology Program Directors, Fellows, and Fellowship Graduates
Point-of-Care Ultrasound Use in Nephrology: A Survey of Nephrology Program Directors, Fellows, and Fellowship Graduates Open
Nephrology program directors, fellows, and graduates surveyed want POCUS training incorporated into the fellowship curriculum. No group felt sufficiently trained to confidently perform POCUS, and the major barrier to training was lack of s…