Sabyasachi Sen
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SAT-536 How Do Metabolic Dysfunction Associated Steatosis Liver Disease (MASLD) and Depression in Veterans with T2DM respond to novel medications Open
Disclosure: S.D. Ubalde: None. J. Khoury: None. S. Sen: None. Background: In this project we wanted to explore the association between Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD) and Depression in Veterans with Type-2 …
Combinatorial mutagenesis of N-terminal sequences reveals unexpected and expanded stability determinants of the <i>Escherichia coli</i> N-degron pathway Open
Summary Although it is known that residues near the N-terminus can influence protein stability, there has not been a comprehensive effort to document how these penultimate residues impact protein stability in prokaryotes. Here, we utilize …
SGLT2 inhibitors use in kidney disease: what did we learn? Open
Chronic kidney disease (CKD) increases the risk for cardiovascular morbidity and mortality and it’s prevalence continues to rise throughout the world. Newer, more efficacious therapies, slow progression of CKD, decrease long-term sequela l…
View article: PredictMod: A Platform for Predicting Medical Intervention Outcomes and Sharing Custom ML/AI Models
PredictMod: A Platform for Predicting Medical Intervention Outcomes and Sharing Custom ML/AI Models Open
Machine learning/artificial intelligence (ML/AI)-based predictive modeling is becoming increasingly popular in healthcare, particularly within the scope of precision medicine. Models based on patient data are effective tools for clinical d…
7440 Both GLP-1RA and SGLT2i medications are associated with lower depression scores in veterans compared to metformin and insulin Open
Disclosure: S.D. Ubalde: None. H. Cann: None. L. Esper: None. J. Powell: None. K. Meyer: None. S. Sen: None. Background: Type 2 diabetes (T2DM) and depression are considered bidirectional. Depression and mental health issues are often co-m…
Cardio-renal Effect of Dapagliflozin AND Dapagliflozin- Saxagliptin combination on CD34+ve Hematopoietic Stem Cells (HSCs) and Podocyte specific markers in Type 2 Diabetes (T2DM) subjects: a randomized trial. Open
Introduction: Effect of Dapagliflozin (Dapa) and Dapagliflozin-Saxagliptin combination (Combo) was examined on peripheral blood derived CD34 + Hematopoetic Stem Cells (HSC) as a cellular CVD biomarker. Both Dapa (a sodium-glucose co-transp…
Podocyte specific protein expression in urine exosome acts as a marker for renal injury in Long-COVID Open
Introduction: SARS-CoV2 has been associated with cardiometabolic diseases. At a cellular level, the infection may cause cellular inflammation and endothelial cell dysfunction (ECD). ECD is common in cardiometabolic diseases and is often as…
Exercise for patients with chronic kidney disease: from cells to systems to function Open
Chronic kidney disease (CKD) is among the leading causes of death and disability, affecting an estimated 800 million adults globally. The underlying pathophysiology of CKD is complex creating challenges to its management. Primary risk fact…
FRI648 GLP-1RA And SGLT2i Treatments May Show Improved Depression Metrics In Diabetes Treatment Open
Disclosure: A. Jain: None. L. Esper: None. J. Powell: None. K. Meyer: None. S. Sen: None. Background: Depression is a widespread condition that develops due to a multitude of etiologies. Type 2 Diabetes (T2DM) is associated with several co…
FRI209 Psychiatric Illness Masking Autoimmune Polyglandular Syndrome In A Middle-aged Woman Open
Disclosure: L. Esper: None. A. Ibrahim: None. S. Sen: None. Introduction: Autoimmune polyglandular syndrome type 2 (APS-2) or Schmidt's syndrome, is a rare disorder characterized by the coexistence of autoimmune adrenal and thyroid disease…
Cardiovascular disease (CVD) risk assessment of HIV medication regimens using hematopoietic CD34+ progenitor cells Open
Background To determine the effects of integrase inhibitor (INSTI) in comparison with non-INSTI-based regimens such as non-nucleoside reverse transcriptase inhibitors (NNRTIs)-based regimens on cardiovascular disease (CVD) risk in HIV+ pat…
Cardiovascular Disease (CVD) Risk Assessment of HIV Medication Regimens using hematopoietic CD34+ progenitor cells Open
Background To determine the effects of integrase inhibitor (INSTI) in comparison to non INSTI based regimens such as non-nucleoside reverse transcriptase inhibitors (NNRTIs) based regimens on cardiovascular disease (CVD) risk in HIV+ patie…
View article: Psychosocial stress and neuroendocrine biomarker concentrations among women living with or without HIV
Psychosocial stress and neuroendocrine biomarker concentrations among women living with or without HIV Open
Objective Women living with HIV (WLWH) experience psychosocial stress related to social-structural vulnerabilities. To investigate neuroendocrine pathways linking stress and increased cardiovascular disease risk among WLWH, we evaluated as…
<i>De novo</i> biosynthesis of <i>para</i>-nitro-L-phenylalanine in <i>Escherichia coli</i> Open
Nitroaromatic functional groups can impart valuable properties to chemicals and to biological macromolecules including polypeptides. Para -nitro-L-phenylalanine (pN-Phe) is a nitroaromatic amino acid with uses including immune stimulation …
Comparison Between Linagliptin and Canagliflozin Effect on Inflammatory Markers, CD34+ Cell Gene Expression and Urine Exosomes in Type 2 Diabetes Subjects Open
Introduction: Peripheral blood derived CD34 +ve Endothelial progenitor cells (EPCs) has been shown to help vascular regeneration and are dysfunctional in subjects with type 2 diabetes mellitus (T2DM) leading to poor endothelial cell functi…
Resolution of hyperthyroidism and thyroid antibodies following struma ovarii resection: an uncommon entity Open
We report a case of 34-year-old clinically asymptomatic woman who had been followed for 6 years for hyperthyroidism with thyroid stimulating hormone <0.006 uIU/mL, free T4 1.98 ng/mL, free T3 5.3 pg/mL, elevated thyroid stimulating immunog…
Transplantation of Apoptosis‐Resistant Endothelial Progenitor Cells Improves Renal Function in Diabetic Kidney Disease Open
Background Diabetic kidney disease is associated with glomerulosclerosis and poor renal perfusion. Increased capillary formation and improved perfusion may help to halt or reverse the injury. Transplanting apoptosis‐resistant p53‐silenced …
Role of Canagliflozin on function of CD34+ endothelial progenitor cells (EPC) in patients with type 2 diabetes Open
Background: Endothelial Progenitor cells (EPCs) has been shown to be dysfunctional in both type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD) leading to poor regeneration of endothelium and renal perfusion. EPCs have been sho…
COVID-19 Biomarkers in research: Extension of the OncoMX cancer biomarker data model to capture biomarker data from other diseases Open
Scientists, medical researchers, and health care workers have mobilized worldwide in response to the outbreak of COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; SCoV2). Preliminary data have captured a wide…
Sucralose promotes accumulation of reactive oxygen species (ROS) and adipogenesis in mesenchymal stromal cells Open
Consumption of non-nutritive sweeteners (NNS) has been consistently associated with obesity and cardiometabolic disease in epidemiologic studies. Herein, we investigated effects of sucralose, a widely used NNS, at a cellular level. We want…
Depression and Psychosocial Stress Are Associated With Subclinical Carotid Atherosclerosis Among Women Living With HIV Open
Background To identify reasons for increased atherosclerotic risk among women living with HIV ( WLWH ), we evaluated the associations between psychosocial risk factors (depressive symptoms, perceived stress, and posttraumatic stress disord…
SUN-578 Role of Linagliptin on CD34+ Endothelial Progenitor Cells and Arterial Stiffness in Renal Function Impaired Type 2 Diabetes Subjects Open
Introduction: Endothelial Progenitor cells (EPCs) has been shown to be dysfunctional in both Type 2 Diabetes and Chronic Kidney Disease (CKD) leading to poor regeneration of endothelium and renal tubules. EPCs have been shown to be a robus…
Linagliptin, when compared to placebo, improves CD34+ve Endothelial Progenitor Cells in Type 2 diabetes subjects with chronic kidney disease taking metformin and/or insulin, a randomized controlled trial. Open
Introduction: Endothelial Progenitor cells (EPCs) has been shown to be dysfunctional in both Type 2 Diabetes and Chronic Kidney Disease (CKD) leading to poor regeneration of endothelium and renal perfusion. EPCs have been shown to be a rob…
The Role of Physical Activity on Insulin Resistance-Associated Endothelial Dysfunction Open
Enhanced physical activity and cardiorespiratory fitness significantly impact morbidity and mortality across the spectrum of noncommunicative chronic illnesses experienced by modern lifestyles. Physical activity itself prompts an intricate…
Redox Control of Vascular Biology Open
Oxidative stress and nitrosative stress are defined as a disruption of redox signaling and control.Homeostatic concentrations of reactive oxygen species (ROS) and reactive nitrogen species (RNS) play a crucial role as secondary messengers …