Sanjib Kumar Sharma
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View article: Implementation of the community health system innovation project in three low- and middle-income countries: COHESION-I study protocol
Implementation of the community health system innovation project in three low- and middle-income countries: COHESION-I study protocol Open
Background The COmmunity HEalth System InnovatiON (COHESION) project (2016–2019) was a 4-year collaboration between research teams from Mozambique, Nepal, Peru and Switzerland. It conducted formative health system research using tracer chr…
View article: Assessing the Impact of Early Marriage and Socioeconomic Determinants on Under-Five Morbidity: A Cross-Country Analysis in South Asia
Assessing the Impact of Early Marriage and Socioeconomic Determinants on Under-Five Morbidity: A Cross-Country Analysis in South Asia Open
Background: Early marriage and socioeconomic factors, which expose young mothers to early pregnancy under situations of adversity, as a result, dramatically raise the risk of children’s morbidity and perpetuate intergenerational cycles of …
View article: Predicting Acute Respiratory Infection Risk in Under–Five Children Using Machine Learning: Evidence from Bangladesh
Predicting Acute Respiratory Infection Risk in Under–Five Children Using Machine Learning: Evidence from Bangladesh Open
Background Children’s immune systems are particularly vulnerable to infections. In developing countries, malnutrition, diarrheal diseases, and acute respiratory infections (ARI) remain leading causes of illness and mortality among children…
View article: Management of acute kidney disease as part of routine clinical care in low-resource settings: The International Society of Nephrology Kidney Care Network Project
Management of acute kidney disease as part of routine clinical care in low-resource settings: The International Society of Nephrology Kidney Care Network Project Open
Acute Kidney Disease (AKD) commonly affects disadvantaged populations in low-resourced areas with poor access to kidney care. Here, barriers to management include a lack of AKD education alongside an inability to measure serum creatinine (…
View article: Encrusted Cystitis: A Rare Morbid Disease
Encrusted Cystitis: A Rare Morbid Disease Open
A BSTRACT Encrusted cystitis (EC) is a rare clinical entity, with the first description dating back to 1914 by Francois J. This variety of debilitating and rare cystitis is caused by urea-splitting Corynebacterium urealyticum , especially …
View article: Histopathological spectrum of lesions of oral cavity and oropharynx in a tertiary care center
Histopathological spectrum of lesions of oral cavity and oropharynx in a tertiary care center Open
Background: Oral cavity and oropharynx are involved by a variety of non neoplastic and neoplastic lesions. Among these, oral cancer is a major malignancy with higher incidence in developing countries. Aims and Objectives: To assess the his…
View article: Clinico-epidemiological study of snakebite: an audit of 13 years of data from a community-based treatment centre in eastern Nepal
Clinico-epidemiological study of snakebite: an audit of 13 years of data from a community-based treatment centre in eastern Nepal Open
Background Snakebite envenomation is a global public health concern, especially in tropical and subtropical regions. We describe the demography, presentations, treatments and outcomes of snakebites from a community snakebite treatment cent…
View article: The risk of death according to left ventricular ejection fraction and right ventricular dilatation in 17 321 adults with heart failure from 40 high‐, middle‐ and low‐income countries – A Global Congestive Heart Failure (G‐ <scp>CHF</scp> ) study
The risk of death according to left ventricular ejection fraction and right ventricular dilatation in 17 321 adults with heart failure from 40 high‐, middle‐ and low‐income countries – A Global Congestive Heart Failure (G‐ <span>CHF</span> ) study Open
Aims The aim of this study was to describe the prognostic importance of left ventricular ejection fraction (LVEF) versus right ventricular (RV) dilatation and dysfunction in patients with heart failure (HF) from countries of different inco…
View article: Routine Spironolactone in Acute Myocardial Infarction
Routine Spironolactone in Acute Myocardial Infarction Open
Among patients with myocardial infarction, spironolactone did not reduce the incidence of death from cardiovascular causes or new or worsening heart failure or the incidence of a composite of death from cardiovascular causes, myocardial in…
View article: Colchicine in Acute Myocardial Infarction
Colchicine in Acute Myocardial Infarction Open
Among patients who had myocardial infarction, treatment with colchicine, when started soon after myocardial infarction and continued for a median of 3 years, did not reduce the incidence of the composite primary outcome (death from cardiov…
View article: Identification and outcomes of acute kidney disease in patients presenting in Bolivia, Brazil, South Africa, and Nepal
Identification and outcomes of acute kidney disease in patients presenting in Bolivia, Brazil, South Africa, and Nepal Open
Background The International Society of Nephrology proposes an acute kidney disease (AKD) management strategy that includes a risk score to aid AKD identification in low- and low-middle-income countries (LLMICs). We investigated the perfor…
View article: Performance and usability of cardiometabolic point of care devices in Nepal: A prospective, quantitative, accuracy study
Performance and usability of cardiometabolic point of care devices in Nepal: A prospective, quantitative, accuracy study Open
Non-communicable diseases (NCDs), such as cardiovascular disease and diabetes, represent a serious global health concern. There is an urgent need for prompt diagnosis and effective monitoring at point of care, especially in low- and middle…
View article: Evaluation of hydroxychloroquine or chloroquine for the prevention of COVID-19 (COPCOV): A double-blind, randomised, placebo-controlled trial
Evaluation of hydroxychloroquine or chloroquine for the prevention of COVID-19 (COPCOV): A double-blind, randomised, placebo-controlled trial Open
Background Hydroxychloroquine (HCQ) has proved ineffective in treating patients hospitalised with Coronavirus Disease 2019 (COVID-19), but uncertainty remains over its safety and efficacy in chemoprevention. Previous chemoprevention random…
View article: Core outcome set for intervention research on snakebite envenomation in South Asia
Core outcome set for intervention research on snakebite envenomation in South Asia Open
Background The 2019 WHO strategy to reduce snakebite burden emphasises the need for fostering research on snakebite treatments. A core outcome set (COS) is a consensus minimal list of outcomes that should be measured in research on a parti…
View article: Comprehensive geriatric assessment-based frailty clinic in a low middle income country: Time to act
Comprehensive geriatric assessment-based frailty clinic in a low middle income country: Time to act Open
Comprehensive Geriatric Assessment (CGA) is a process of care that involves a holistic, multidimensional, interdisciplinary assessment of an older individual and has been demonstrated to be the choice of management for frailty. By 2050, it…
View article: Migrant Work and Kidney Health in Nepal
Migrant Work and Kidney Health in Nepal Open
1Professor, Department of Internal Medicine, BP Koirala Instittute of Health Sciences, Dharan Nepal 2Chief, Quality Standards and Regulation Division, Ministry of Health and Population, Nepal. This is an open access article distributed und…
View article: Early detection and management of heart failure and its associated risk factors: prospect for task shifting among healthcare workers
Early detection and management of heart failure and its associated risk factors: prospect for task shifting among healthcare workers Open
Background Cardiovascular diseases (CVDs) are a major cause of morbidity and mortality in low- and middle- income countries (LMICs) like Nepal. CVDs contribute to a major share, along with other NCDs, in causing poverty due to catastrophic…
View article: Effects of Flaxseed on Blood Pressure in Patients Taking Antihypertensive Drugs: A Randomized Trial
Effects of Flaxseed on Blood Pressure in Patients Taking Antihypertensive Drugs: A Randomized Trial Open
BackgroundThe cardiovascular protective effects of consuming flaxseed, such as improving lipid profile and reducing inflammatory markers, have been studied in both animals and humans. This study aimed to assess the effects of flaxseed in p…
View article: Prevalence of multimorbidity and its associated risk factors among population of Mechinagar municipality of Nepal
Prevalence of multimorbidity and its associated risk factors among population of Mechinagar municipality of Nepal Open
Background Multimorbidity is a group of conditions, it has significant impact on the population as a whole, resulting in lower quality of life, higher mortality, frequent use of medical services, and consequently higher healthcare costs. T…
View article: Posterior reversible encephalopathy syndrome due to nonadherence to antihypertensive treatment: A case report from Nepal
Posterior reversible encephalopathy syndrome due to nonadherence to antihypertensive treatment: A case report from Nepal Open
Key Clinical Message Posterior reversible encephalopathy syndrome may occur secondary to abrupt cessation of antihypertensive therapy. A gradual reduction in blood pressure and counseling regarding medication adherence are crucial to preve…
View article: Decentralization and Integration of Advanced Cardiac Care for the World’s Poorest Billion Through the PEN-Plus Strategy for Severe Chronic Non-Communicable Disease
Decentralization and Integration of Advanced Cardiac Care for the World’s Poorest Billion Through the PEN-Plus Strategy for Severe Chronic Non-Communicable Disease Open
Rheumatic and congenital heart disease, cardiomyopathies, and hypertensive heart disease are major causes of suffering and death in low- and lower middle-income countries (LLMICs), where the world's poorest billion people reside. Advanced …
View article: Correction: Decentralization and Integration of Advanced Cardiac Care for the World’s Poorest Billion Through the PEN-Plus Strategy for Severe Chronic Non-Communicable Disease
Correction: Decentralization and Integration of Advanced Cardiac Care for the World’s Poorest Billion Through the PEN-Plus Strategy for Severe Chronic Non-Communicable Disease Open
[This corrects the article DOI: 10.5334/gh.1313.].
View article: Alteration of Biochemical Parameters in Patients with Respiratory Acidosis and Alkalosis: A Hospital Based CrossSectional Study
Alteration of Biochemical Parameters in Patients with Respiratory Acidosis and Alkalosis: A Hospital Based CrossSectional Study Open
Biochemical parameters like pH, pO2, pCO2, HCO3-, TCO2 and SO2 are frequently measured in critically ill patients with respiratory acidosis and alkalosis. These parameters have utmost importance in the assessment of ventilation, oxygenatio…
View article: Gastric Antral Vascular Ectasia as a Reversible Cause of Upper Gastrointestinal Bleeding in the Oldest Old
Gastric Antral Vascular Ectasia as a Reversible Cause of Upper Gastrointestinal Bleeding in the Oldest Old Open
Gastric antral vascular ectasia (GAVE) is a rare condition which accounts for 4% of the nonvariceal acute upper gastrointestinal (GI) bleeding. The mean age of diagnosis is 70 years. This condition is often misdiagnosed as hemorrhagic antr…
View article: Frailty and outcomes in heart failure patients from high-, middle-, and low-income countries
Frailty and outcomes in heart failure patients from high-, middle-, and low-income countries Open
Background and Aims There is little information on the incremental prognostic importance of frailty beyond conventional prognostic variables in heart failure (HF) populations from different country income levels. Methods A total of 3429 ad…
View article: Worm infestation as a cause of severe anemia in a frail older adult: a case report
Worm infestation as a cause of severe anemia in a frail older adult: a case report Open
Introduction: Worm infestations are a common occurrence in low-income countries. Anemia due to iron deficiency can be brought on by human intestinal worms. The authors report a case of an 86-year-old frail older adult with upper gastrointe…
View article: Management of hemorrhagic pleural effusion with intrapleural streptokinase in a patient on peritoneal dialysis and dual antiplatelet therapy
Management of hemorrhagic pleural effusion with intrapleural streptokinase in a patient on peritoneal dialysis and dual antiplatelet therapy Open
Key Clinical Message Intrapleural streptokinase can be an option for loculated hemorrhagic pleural effusion among patients receiving CAPD and under DAPT. Its use can be individualized based on risk benefit analysis by the treating clinicia…