Samreen Gul Khan
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View article: Comparison of the Incidence of Postdural Puncture Headache Following Spinal Anesthesia in Cesarean Sections Using 25g and 27g Needles With Median and Paramedian Approaches
Comparison of the Incidence of Postdural Puncture Headache Following Spinal Anesthesia in Cesarean Sections Using 25g and 27g Needles With Median and Paramedian Approaches Open
Background: The occurrence and intensity of PDPH can be affected by several factors, including the caliber of the spinal needle and the technique employed during anesthesia. Although the median approach is conventionally used, the paramedi…
View article: Corey–Fuchs reaction enabled synthesis of natural products: a review
Corey–Fuchs reaction enabled synthesis of natural products: a review Open
Corey–Fuchs reaction is a two-step reaction involving the synthesis of terminal alkyne from aldehyde. It is a pivotal organic reaction, plays a significant role in the synthesis of various natural products and their derivatives.
View article: A review on the sulfur ylide-mediated Corey–Chaykovsky reaction: a powerful approach to natural product synthesis
A review on the sulfur ylide-mediated Corey–Chaykovsky reaction: a powerful approach to natural product synthesis Open
The current review summarizes the recent applications of Corey–Chaykovsky reaction toward the total synthesis of several classes of natural products i.e. , alkaloids, terpenoids, depsipeptides, polyketides and amino acids, etc.
View article: Novel transition metal-free synthetic protocols toward the construction of 2,3-dihydrobenzofurans: a recent update
Novel transition metal-free synthetic protocols toward the construction of 2,3-dihydrobenzofurans: a recent update Open
2,3-Dihydrobenzofurans are noteworthy scaffolds in organic and medicinal chemistry, constituting the structural framework of many of the varied medicinally active organic compounds. Moreover, a diverse variety of biologically potent natura…
View article: Design, Synthesis and Biological Exploration of Novel N-(9-Ethyl-9H-Carbazol-3-yl)Acetamide-Linked Benzofuran-1,2,4-Triazoles as Anti-SARS-CoV-2 Agents: Combined Wet/Dry Approach Targeting Main Protease (Mpro), Spike Glycoprotein and RdRp
Design, Synthesis and Biological Exploration of Novel N-(9-Ethyl-9H-Carbazol-3-yl)Acetamide-Linked Benzofuran-1,2,4-Triazoles as Anti-SARS-CoV-2 Agents: Combined Wet/Dry Approach Targeting Main Protease (Mpro), Spike Glycoprotein and RdRp Open
A novel series of substituted benzofuran-tethered triazolylcarbazoles was synthesized in good to high yields (65–89%) via S-alkylation of benzofuran-based triazoles with 2-bromo-N-(9-ethyl-9H-carbazol-3-yl)acetamide. The inhibitory potency…
View article: A Comprehensive Review on Benzofuran Synthesis Featuring Innovative and Catalytic Strategies
A Comprehensive Review on Benzofuran Synthesis Featuring Innovative and Catalytic Strategies Open
Benzofurans have intrigued both pharmaceutical researchers and chemists owing to the medicinal usage of their derivatives against copious disease-causing agents (i.e., bacteria, viruses, and tumors). These heterocyclic scaffolds are pervas…
View article: Grignard Reaction: An ‘Old-Yet-Gold’ synthetic gadget toward the synthesis of natural Products: A review
Grignard Reaction: An ‘Old-Yet-Gold’ synthetic gadget toward the synthesis of natural Products: A review Open
Natural product synthesis is an important area of chemical study having various prospects for medicinal, industrial, and agricultural industry. Grignard reaction was developed as a flexible and necessary tool for the production of complex …
View article: Tuning of end-groups in diketopyrrolopyrrole-based acceptors molecules for organic photovoltaics
Tuning of end-groups in diketopyrrolopyrrole-based acceptors molecules for organic photovoltaics Open
In this computational approach, four small novel acceptor molecules of A2-D-A1-D-A2 type have been designed (S1-S4) by the replacement of terminal acceptor groups (A2) of R molecule with four different types of electron accepting-units. Th…
View article: Baeyer–Villiger oxidation: a promising tool for the synthesis of natural products: a review
Baeyer–Villiger oxidation: a promising tool for the synthesis of natural products: a review Open
Baeyer–Villiger oxidation is a renowned reaction that provides an efficient route for the synthesis of biologically active natural products such as alkaloids, terpenoids, polyketides and fatty acid-based naturally occurring organic compoun…
View article: Discovery of novel 1,2,4-triazole tethered β-hydroxy sulfides as bacterial tyrosinase inhibitors: synthesis and biophysical evaluation through <i>in vitro</i> and <i>in silico</i> approaches
Discovery of novel 1,2,4-triazole tethered β-hydroxy sulfides as bacterial tyrosinase inhibitors: synthesis and biophysical evaluation through <i>in vitro</i> and <i>in silico</i> approaches Open
This study reports the bacterial tyrosinase inhibiting potency of a series of novel 1,2,4-triazole-tethered β-hydroxy sulfide scaffolds 11(a–h), synthesized in good yields (69–90%).
View article: Accessing the synthesis of natural products and their analogues enabled by the Barbier reaction: a review
Accessing the synthesis of natural products and their analogues enabled by the Barbier reaction: a review Open
The latest utilization of the Barbier reaction and its variants towards the procurement of diverse natural products i.e. , alkaloids, terpenoids, lactones and lignans etc. has been summarized in this review article.
View article: An Exploration of the Inhibitory Mechanism of Rationally Screened Benzofuran-1,3,4-Oxadiazoles and-1,2,4-Triazoles as Inhibitors of NS5B RdRp Hepatitis C Virus through Pharmacoinformatic Approaches
An Exploration of the Inhibitory Mechanism of Rationally Screened Benzofuran-1,3,4-Oxadiazoles and-1,2,4-Triazoles as Inhibitors of NS5B RdRp Hepatitis C Virus through Pharmacoinformatic Approaches Open
Benzofuran, 1,3,4-oxadiazole, and 1,2,4-triazole are privileged heterocyclic moieties that display the most promising and wide spectrum of biological activities against a wide variety of diseases. In the current study, benzofuran-1,3,4-oxa…
View article: Bacterial Tyrosinase Inhibition, Hemolytic and Thrombolytic Screening, and In Silico Modeling of Rationally Designed Tosyl Piperazine-Engrafted Dithiocarbamate Derivatives
Bacterial Tyrosinase Inhibition, Hemolytic and Thrombolytic Screening, and In Silico Modeling of Rationally Designed Tosyl Piperazine-Engrafted Dithiocarbamate Derivatives Open
Piperazine is a privileged moiety that is a structural part of many clinical drugs. Piperazine-based scaffolds have attracted the attention of pharmaceutical and medicinal scientists to develop novel, efficient therapeutic agents owing to …
View article: Simmons–Smith Cyclopropanation: A Multifaceted Synthetic Protocol toward the Synthesis of Natural Products and Drugs: A Review
Simmons–Smith Cyclopropanation: A Multifaceted Synthetic Protocol toward the Synthesis of Natural Products and Drugs: A Review Open
Simmons–Smith cyclopropanation is a widely used reaction in organic synthesis for stereospecific conversion of alkenes into cyclopropane. The utility of this reaction can be realized by the fact that the cyclopropane motif is a privileged …
View article: Synthetic Potential of Regio- and Stereoselective Ring Expansion Reactions of Six-Membered Carbo- and Heterocyclic Ring Systems: A Review
Synthetic Potential of Regio- and Stereoselective Ring Expansion Reactions of Six-Membered Carbo- and Heterocyclic Ring Systems: A Review Open
Ring expansion reactions fascinate synthetic chemists owing to their importance in synthesizing biologically active compounds and their efficacy in medicinal chemistry. The present review summarizes a number of synthetic methodologies, inc…
View article: Protease inhibition, in vitro antibacterial and IFD/MM-GBSA studies of ciprofloxacin-based acetanilides
Protease inhibition, in vitro antibacterial and IFD/MM-GBSA studies of ciprofloxacin-based acetanilides Open
In this study, we have investigated ciprofloxacin-based acetanilides for their in - vitro inhibitory study against gram +ve, -ve bacteria and serine protease activity. The compounds 4e and 4g showed excellent antibacterial activity against…
View article: Microbial Fuel Cell Formulation from Nano-Composites
Microbial Fuel Cell Formulation from Nano-Composites Open
Petroleum and oil industry is a rich source of nonrenewable energy that ultimately results in threatening of ecosystem due to emission of greenhouse gases into the environment. In the current panorama of the energy demand, industries focus…
View article: Bio-Oriented Synthesis and Molecular Docking Studies of 1,2,4-Triazole Based Derivatives as Potential Anti-Cancer Agents against HepG2 Cell Line
Bio-Oriented Synthesis and Molecular Docking Studies of 1,2,4-Triazole Based Derivatives as Potential Anti-Cancer Agents against HepG2 Cell Line Open
Triazole-based acetamides serve as important scaffolds for various pharmacologically active drugs. In the present work, structural hybrids of 1,2,4-triazole and acetamides were furnished by chemically modifying 2-(4-isobutylphenyl) propano…
View article: A facile synthesis of 1,3,4-oxadiazole-based carbamothioate molecules: Antiseizure potential, EEG evaluation and in-silico docking studies
A facile synthesis of 1,3,4-oxadiazole-based carbamothioate molecules: Antiseizure potential, EEG evaluation and in-silico docking studies Open
In present work, a series of novel structural hybrids of 1,3,4-oxadiazole and carbamothioate was designed by chemical modification of 2-(4-isobutylphenyl)propanoic acid. Target compounds (7a-f) were synthesized in significant yields (84–88…
View article: Comprehensive Metabolomic Fingerprinting Combined with Chemometrics Identifies Species- and Variety-Specific Variation of Medicinal Herbs: An Ocimum Study
Comprehensive Metabolomic Fingerprinting Combined with Chemometrics Identifies Species- and Variety-Specific Variation of Medicinal Herbs: An Ocimum Study Open
Identification of plant species is a crucial process in natural products. Ocimum, often referred to as the queen of herbs, is one of the most versatile and globally used medicinal herbs for various health benefits due to it having a wide v…
View article: Reliability of mantoux in diagnosis of tuberculosis and factors affecting it
Reliability of mantoux in diagnosis of tuberculosis and factors affecting it Open
This study was conducted to determine the frequency of infected children cohabiting with sputum-positive and negative tuberculous adults for grounding the authenticity of the Montoux test in diagnosing tuberculosis among these groups. It w…
View article: Ultrasound Assisted Synthesis and In Silico Modelling of 1,2,4-Triazole Coupled Acetamide Derivatives of 2-(4-Isobutyl phenyl)propanoic acid as Potential Anticancer Agents
Ultrasound Assisted Synthesis and In Silico Modelling of 1,2,4-Triazole Coupled Acetamide Derivatives of 2-(4-Isobutyl phenyl)propanoic acid as Potential Anticancer Agents Open
The development of an economical method for the synthesis of biologically active compounds was the major goal of this research. In the present study, we have reported the ultrasound-radiation-assisted synthesis of a series of novel N-subst…
View article: Variable presentations of radiation-associated angiosarcoma in patients treated for breast cancer
Variable presentations of radiation-associated angiosarcoma in patients treated for breast cancer Open
Introduction: Radiation-associated angiosarcoma is a rare and late complication of radiotherapy in breast cancer. Its incident is reported in the range of 0.03–0.3%. It carries a poor prognosis with a 5-year survival rate of 43–54%. Due to…
View article: Etiology of Hepatocellular Carcinoma and Association with Hepatitis B & C Virus
Etiology of Hepatocellular Carcinoma and Association with Hepatitis B & C Virus Open
Aim: To evaluate the association of hepatitis with the hepatocellular carcinoma. Hepatitis is known as the inflammation of the liver. Methods: Hepatitis C and B may lead to HCC (hepatocellular carcinoma), such as Hepatitis B may cause 50% …
View article: Genetic Diversity in Almond (<i>Prunus dulcis</i>)
Genetic Diversity in Almond (<i>Prunus dulcis</i>) Open
Almond (Prunus dulcis), a stone fruit belonging to a family Rosaceae (rose) is broadly cultivated for ornament and fruit. Within this genus, the almond is very much associated with the peach, and these two fruits share the same subgenus th…
View article: Photocatalytic Applications of Titanium Dioxide (TiO<sub>2</sub>)
Photocatalytic Applications of Titanium Dioxide (TiO<sub>2</sub>) Open
Water pollution is one the fundamental problems that have got the serious concerns of the researchers. Water poluution arises due to a number of reasons including domestic, industrial, agricultural, scinec and technology. The textile indus…