Samuel Arregui
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View article: <i>DEFA1A3</i>DNA gene-dosage regulates the kidney innate immune response during upper urinary tract infection
<i>DEFA1A3</i>DNA gene-dosage regulates the kidney innate immune response during upper urinary tract infection Open
Antimicrobial peptides (AMPs) are host defense effectors with potent neutralizing and immunomodulatory functions against invasive pathogens. The AMPs α-Defensin 1-3/ DEFA1A3 participate in innate immune responses and influence patient outc…
View article: Generation of <i>Atp6v1g3</i>-Cre mice for investigation of intercalated cells and the collecting duct
Generation of <i>Atp6v1g3</i>-Cre mice for investigation of intercalated cells and the collecting duct Open
This study details the development, validation, and experimental use of a new mouse model to study the collecting duct and intercalated cells. Kidney intercalated cells are a cell type increasingly recognized to be important in several hum…
View article: Human neutrophil peptides 1-3 protect the murine urinary tract from uropathogenic <i>Escherichia coli</i> challenge
Human neutrophil peptides 1-3 protect the murine urinary tract from uropathogenic <i>Escherichia coli</i> challenge Open
Antimicrobial peptides (AMPs) are critical to the protection of the urinary tract of humans and other animals from pathogenic microbial invasion. AMPs rapidly destroy pathogens by disrupting microbial membranes and/or augmenting or inhibit…
View article: MAP3K7 is an innate immune regulatory gene with increased expression in human and murine kidney intercalated cells following uropathogenic <i>Escherichia coli</i> exposure
MAP3K7 is an innate immune regulatory gene with increased expression in human and murine kidney intercalated cells following uropathogenic <i>Escherichia coli</i> exposure Open
Understanding the mechanisms responsible for the kidney's defense against ascending uropathogen is critical to devise novel treatment strategies against increasingly antibiotic resistant uropathogen. Growing body of evidence indicate Inter…
View article: Deleted in malignant brain tumor <i>1</i> genetic variation confers urinary tract infection risk in children and mice
Deleted in malignant brain tumor <i>1</i> genetic variation confers urinary tract infection risk in children and mice Open
We identify that children with a history of urinary tract infections (UTIs) and vesicoureteral reflux (VUR) with low deleted in Malignant Brain Tumors 1 (DMBT1) DNA copy number have ∼4-fold higher odds of recurrent UTIs compared to those w…
View article: Placement on COVID-19 Units Does Not Increase Seroconversion Rate of Pediatric Graduate Medical Residents
Placement on COVID-19 Units Does Not Increase Seroconversion Rate of Pediatric Graduate Medical Residents Open
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its associated disease COVID-19 (coronavirus disease 2019) has presented graduate medical education (GME) training programs with a unique set of challenges. One o…
View article: Kidney intercalated cells are phagocytic and acidify internalized uropathogenic Escherichia coli
Kidney intercalated cells are phagocytic and acidify internalized uropathogenic Escherichia coli Open
Kidney intercalated cells are involved in acid-base homeostasis via vacuolar ATPase expression. Here we report six human intercalated cell subtypes, including hybrid principal-intercalated cells identified from single cell transcriptomics.…
View article: Assessment of Seroconversion to SARS-CoV-2 in a Cohort of Pediatric Kidney Transplant Recipients
Assessment of Seroconversion to SARS-CoV-2 in a Cohort of Pediatric Kidney Transplant Recipients Open
Background: The occurrence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the associated coronavirus disease 2019 (COVID-19) have profoundly affected adult kidney disease patients. In contrast, pediatric solid orga…
View article: Aptamer based proteomic pilot study reveals a urine signature indicative of pediatric urinary tract infections
Aptamer based proteomic pilot study reveals a urine signature indicative of pediatric urinary tract infections Open
Biomarkers panel can be identified by the emerging technologies of aptamer-based proteomics and machine learning that offer the potential to increase UTI diagnostic accuracy, thereby limiting unneeded antibiotics.
View article: Developmental loss, but not pharmacological suppression, of renal carbonic anhydrase 2 results in pyelonephritis susceptibility
Developmental loss, but not pharmacological suppression, of renal carbonic anhydrase 2 results in pyelonephritis susceptibility Open
Carbonic anhydrase II knockout ( Car2 −/− ) mice have depleted numbers of renal intercalated cells, which are increasingly recognized to be innate immune effectors. We compared pyelonephritis susceptibility following reciprocal renal trans…