Samuel Blankson
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View article: Gossypol is a natural product with good antimalarial activity against Plasmodium falciparum clinical isolates
Gossypol is a natural product with good antimalarial activity against Plasmodium falciparum clinical isolates Open
Gossypol has demonstrated significant antimalarial activity against chloroquine-resistant and susceptible Plasmodium falciparum parasites. However, data on its potency in clinical isolates of P. falciparum remains limited. This study aimed…
View article: Gossypol, a natural product has good antimalarial activity of against Plasmodium falciparum clinical isolates
Gossypol, a natural product has good antimalarial activity of against Plasmodium falciparum clinical isolates Open
Gossypol is known to have good antimalarial activities against chloroquine-resistant and susceptible Plasmodium falciparum parasites. However, there is limited data on its potency in clinical isolates of P. falciparum. Therefore, this stud…
View article: High Plasma Levels of Neopterin Are Associated with Increased Mortality among Children with Severe Malaria in Benin
High Plasma Levels of Neopterin Are Associated with Increased Mortality among Children with Severe Malaria in Benin Open
Among the barriers to accessing adequate treatment and high-level monitoring for malaria febrile patients is the lack of effective prognostic markers. Neopterin, which is a marker of monocyte/macrophage activation, was found have increased…
View article: Association of Endothelial Protein C Receptor (EPCR) rs867186 Gene Polymorphism With Increased Levels of Soluble EPCR and High Risk of Severe Malaria and Fatality in Beninese Children
Association of Endothelial Protein C Receptor (EPCR) rs867186 Gene Polymorphism With Increased Levels of Soluble EPCR and High Risk of Severe Malaria and Fatality in Beninese Children Open
The endothelial protein C receptor (EPCR)–rs867186 G allele has been linked to high plasma levels of soluble EPCR (sEPCR) and controversially associated with either susceptibility or resistance to severe and cerebral malaria. In this study…
View article: ICAM-1 Kilifi variant is not associated with cerebral and severe malaria pathogenesis in Beninese children
ICAM-1 Kilifi variant is not associated with cerebral and severe malaria pathogenesis in Beninese children Open
Background Cytoadhesion and sequestration of Plasmodium falciparum infected red blood cells (iRBC) in the microvasculature of vital organs are a major cause of malaria pathology. Several studies have provided evidence on the implication of…
View article: Specific Combinations of Inflammatory, Angiogenesis and Vascular Integrity Biomarkers Are Associated with Clinical Severity, Coma and Mortality in Beninese Children with Plasmodium Falciparum Malaria
Specific Combinations of Inflammatory, Angiogenesis and Vascular Integrity Biomarkers Are Associated with Clinical Severity, Coma and Mortality in Beninese Children with Plasmodium Falciparum Malaria Open
Malaria-related deaths could be prevented if powerful diagnostic and reliable prognostic biomarkers were available to allow rapid prediction of the clinical severity allowing adequate treatment. Using quantitative ELISA, we assessed the pl…
View article: Procalcitonin, Pentraxine 3, and Molecules of the Vascular Endothelium are Hallmark of Pathogenicity and Predict Coma and Mortality Among Children with Severe and Cerebral Malaria
Procalcitonin, Pentraxine 3, and Molecules of the Vascular Endothelium are Hallmark of Pathogenicity and Predict Coma and Mortality Among Children with Severe and Cerebral Malaria Open
Background: Malaria-related deaths could be prevented if prompt diagnosis and prognostic biomarkers are available to allow rapid adequate treatment. Understanding of the mechanisms implicated in the progression from P. falciparum asymptoma…