Samuel C. Robson
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View article: WITHDRAWN: NanoDel: a long-read sequencing pipeline for identifying large-scale mitochondrial DNA deletions validated in patient samples clinically diagnosed with mitochondrial disease and evaluated in glioblastoma
WITHDRAWN: NanoDel: a long-read sequencing pipeline for identifying large-scale mitochondrial DNA deletions validated in patient samples clinically diagnosed with mitochondrial disease and evaluated in glioblastoma Open
Withdrawal statement The authors have withdrawn this manuscript (MS ID#: BIORXIV/2025/677263) prior to peer-review to perform substantial revisions to the content, including additional data validation and clarification of key conclusions. …
View article: Meeting reports
Meeting reports Open
View article: Behavioural rhythms of two amphipod species Marinogammarus marinus and Gammarus pulex under increasing levels of light at night
Behavioural rhythms of two amphipod species Marinogammarus marinus and Gammarus pulex under increasing levels of light at night Open
Artificial light at night (ALAN) is proliferating at an alarming rate across the globe, particularly around aquatic habitats. Natural and predictable light cycles dictate much of an individual organism’s life by acting as a major signal fo…
View article: Faecal microbiome, gastrointestinal integrity, inflammation and thermoregulation in recent exertional heat illness patients and matched controls
Faecal microbiome, gastrointestinal integrity, inflammation and thermoregulation in recent exertional heat illness patients and matched controls Open
The gastrointestinal (GI) microbiota and GI barrier integrity are hypothesised to contribute to exertional heat illness (EHI) aetiology. We compared the faecal microbiome, GI barrier integrity, inflammation and thermoregulation of 29 recen…
View article: Impact of microbiological molecular methodologies on adaptive sampling using nanopore sequencing in metagenomic studies
Impact of microbiological molecular methodologies on adaptive sampling using nanopore sequencing in metagenomic studies Open
Introduction Metagenomics, the genomic analysis of all species present within a mixed population, is an important tool used for the exploration of microbiomes in clinical and environmental microbiology. Whilst the development of next-gener…
View article: Shedding Light on Amphipod Behaviour: Baseline Locomotion Behaviour in Marinogammarus Marinus for Ecotoxicology Experiments
Shedding Light on Amphipod Behaviour: Baseline Locomotion Behaviour in Marinogammarus Marinus for Ecotoxicology Experiments Open
View article: Impact of nocturnal hypoxia on glycaemic control, appetite, gut microbiota and inflammation in adults with type 2 diabetes mellitus: A single‐blind cross‐over trial
Impact of nocturnal hypoxia on glycaemic control, appetite, gut microbiota and inflammation in adults with type 2 diabetes mellitus: A single‐blind cross‐over trial Open
High altitude residents have a lower incidence of type 2 diabetes mellitus (T2DM). Therefore, we examined the effect of repeated overnight normobaric hypoxic exposure on glycaemic control, appetite, gut microbiota and inflammation in adult…
View article: Salivary <scp>IL</scp>‐8 and <scp>sTREM</scp>‐1 in chronic urticaria: A diagnostic test accuracy study
Salivary <span>IL</span>‐8 and <span>sTREM</span>‐1 in chronic urticaria: A diagnostic test accuracy study Open
Chronic urticaria (CU) is defined as the occurrence of wheals, angioedema or both for more than 6 weeks.1 CU can present with daily/almost daily signs and symptoms or an intermittent/recurrent course.1 CU is further classified, based on th…
View article: angptl4 gene expression as a marker of adaptive homeostatic response to social isolation across the lifespan in zebrafish
angptl4 gene expression as a marker of adaptive homeostatic response to social isolation across the lifespan in zebrafish Open
Social isolation has detrimental health effects, but the underlying mechanisms are unclear. Here, we investigated the impact of 2 weeks of isolation on behavior and gene expression in the central nervous system at different life stages of …
View article: Cardiac competence of the paraxial head mesoderm fades concomitant with a shift towards the head skeletal muscle programme
Cardiac competence of the paraxial head mesoderm fades concomitant with a shift towards the head skeletal muscle programme Open
The vertebrate head mesoderm provides the heart, the great vessels, some smooth and most head skeletal muscle, in addition to parts of the skull. It has been speculated that the ability to generate cardiac and smooth muscle is the evolutio…
View article: Supplementary Tables S1-S8 from Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy
Supplementary Tables S1-S8 from Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy Open
I-CBP112 ΔTm data for bromodomains (S1); I-CBP112 ITC data (S2); Selectivity screening data outside BRD family (S3); ITC data (S4); Data collection and refinement statistics (S5); I-CBP112 deregulated genes 3d KASUMI-1 (S6); I-CBP112 dere…
View article: Supplemental Figures S1-S6 from Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy
Supplemental Figures S1-S6 from Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy Open
BLI evaluation of I-CBP112 selectivity (S1); BioMAP data for I-CBP112 (S2); Effects on MLL-AF9 and NUP98-HOXA9 (S3); Immunophenotype of injected MLL-AF9 cells (S4); Cell survival data (S5); Synergy with JQ1 and doxorubicin (S6).
View article: Supplemental Methods and References from Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy
Supplemental Methods and References from Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy Open
Description of additional methods and procedures used in the study. Also includes Supplemental References.
View article: Supplemental Methods and References from Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy
Supplemental Methods and References from Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy Open
Description of additional methods and procedures used in the study. Also includes Supplemental References.
View article: Data from Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy
Data from Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy Open
The histone acetyltransferases CBP/p300 are involved in recurrent leukemia-associated chromosomal translocations and are key regulators of cell growth. Therefore, efforts to generate inhibitors of CBP/p300 are of clinical value. We develop…
View article: Supplemental Figures S1-S6 from Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy
Supplemental Figures S1-S6 from Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy Open
BLI evaluation of I-CBP112 selectivity (S1); BioMAP data for I-CBP112 (S2); Effects on MLL-AF9 and NUP98-HOXA9 (S3); Immunophenotype of injected MLL-AF9 cells (S4); Cell survival data (S5); Synergy with JQ1 and doxorubicin (S6).
View article: Supplementary Tables S1-S8 from Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy
Supplementary Tables S1-S8 from Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy Open
I-CBP112 ΔTm data for bromodomains (S1); I-CBP112 ITC data (S2); Selectivity screening data outside BRD family (S3); ITC data (S4); Data collection and refinement statistics (S5); I-CBP112 deregulated genes 3d KASUMI-1 (S6); I-CBP112 dere…
View article: Data from Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy
Data from Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy Open
The histone acetyltransferases CBP/p300 are involved in recurrent leukemia-associated chromosomal translocations and are key regulators of cell growth. Therefore, efforts to generate inhibitors of CBP/p300 are of clinical value. We develop…
View article: Combining viral genomics and clinical data to assess risk factors for severe COVID-19 (mortality, ICU admission, or intubation) amongst hospital patients in a large acute UK NHS hospital Trust
Combining viral genomics and clinical data to assess risk factors for severe COVID-19 (mortality, ICU admission, or intubation) amongst hospital patients in a large acute UK NHS hospital Trust Open
Throughout the COVID-19 pandemic, valuable datasets have been collected on the effects of the virus SARS-CoV-2. In this study, we combined whole genome sequencing data with clinical data (including clinical outcomes, demographics, comorbid…
View article: Investigation of hospital discharge cases and SARS-CoV-2 introduction into Lothian care homes
Investigation of hospital discharge cases and SARS-CoV-2 introduction into Lothian care homes Open
View article: Multiple pathways of SARS-CoV-2 nosocomial transmission uncovered by integrated genomic and epidemiological analyses during the second wave of the COVID-19 pandemic in the UK
Multiple pathways of SARS-CoV-2 nosocomial transmission uncovered by integrated genomic and epidemiological analyses during the second wave of the COVID-19 pandemic in the UK Open
Introduction Throughout the global COVID-19 pandemic, nosocomial transmission has represented a major concern for healthcare settings and has accounted for many infections diagnosed within hospitals. As restrictions ease and novel variants…
View article: Developing Biosensors for SARS-CoV-2 Wastewater-Based Epidemiology: A Systematic Review of Trends, Limitations and Future Perspectives
Developing Biosensors for SARS-CoV-2 Wastewater-Based Epidemiology: A Systematic Review of Trends, Limitations and Future Perspectives Open
Wastewater-based epidemiology (WBE) permits the sustainable surveillance of pathogens in large populations and does not discriminate between symptomatic and asymptomatic groups. WBE allows health authorities and policymakers to make swift …
View article: A Review of Cross-Disciplinary Approaches for the Identification of Novel Industrially Relevant Plastic-Degrading Enzymes
A Review of Cross-Disciplinary Approaches for the Identification of Novel Industrially Relevant Plastic-Degrading Enzymes Open
The large-scale global use of plastics has led to one of the greatest environmental issues of the 21st century. The incredible durability of these polymers, whilst beneficial for a wide range of purposes, makes them hard to break down. Tru…
View article: Effectiveness of rapid SARS-CoV-2 genome sequencing in supporting infection control for hospital-onset COVID-19 infection: Multicentre, prospective study
Effectiveness of rapid SARS-CoV-2 genome sequencing in supporting infection control for hospital-onset COVID-19 infection: Multicentre, prospective study Open
Background: Viral sequencing of SARS-CoV-2 has been used for outbreak investigation, but there is limited evidence supporting routine use for infection prevention and control (IPC) within hospital settings. Methods: We conducted a prospect…
View article: Loss of full-length dystrophin expression results in major cell-autonomous abnormalities in proliferating myoblasts
Loss of full-length dystrophin expression results in major cell-autonomous abnormalities in proliferating myoblasts Open
Duchenne muscular dystrophy (DMD) affects myofibers and muscle stem cells, causing progressive muscle degeneration and repair defects. It was unknown whether dystrophic myoblasts—the effector cells of muscle growth and regeneration—are aff…
View article: Author response: Loss of full-length dystrophin expression results in major cell-autonomous abnormalities in proliferating myoblasts
Author response: Loss of full-length dystrophin expression results in major cell-autonomous abnormalities in proliferating myoblasts Open
View article: SARS-CoV-2 lineage dynamics in England from September to November 2021: high diversity of Delta sub-lineages and increased transmissibility of AY.4.2
SARS-CoV-2 lineage dynamics in England from September to November 2021: high diversity of Delta sub-lineages and increased transmissibility of AY.4.2 Open
View article: Genomic epidemiology of SARS-CoV-2 in a university outbreak setting and implications for public health planning
Genomic epidemiology of SARS-CoV-2 in a university outbreak setting and implications for public health planning Open
View article: Author response: Effectiveness of rapid SARS-CoV-2 genome sequencing in supporting infection control for hospital-onset COVID-19 infection: Multicentre, prospective study
Author response: Effectiveness of rapid SARS-CoV-2 genome sequencing in supporting infection control for hospital-onset COVID-19 infection: Multicentre, prospective study Open
Article Figures and data Abstract Editor's evaluation Introduction Methods Results Discussion Appendix 1 Data availability References Decision letter Author response Article and author information Metrics Abstract Background: Viral sequenc…
View article: Biomimetic generation of the strongest known biomaterial found in limpet tooth
Biomimetic generation of the strongest known biomaterial found in limpet tooth Open
The biomaterial with the highest known tensile strength is a unique composite of chitin and goethite (α-FeO(OH)) present in teeth from the Common Limpet ( Patella vulgata ). A biomimetic based on limpet tooth, with corresponding high-perfo…