Samuel Corless
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View article: Revisiting the question: When is a centromere not a kinetochore?
Revisiting the question: When is a centromere not a kinetochore? Open
Centromeres have been the focus of extensive research for almost a century, so it may come as a surprise that a consistent definition and nomenclature for these structures remains elusive. In recent times, centromeric chromatin is most fre…
View article: Near millimolar concentration of nucleosomes in mitotic chromosomes from late prometaphase into anaphase
Near millimolar concentration of nucleosomes in mitotic chromosomes from late prometaphase into anaphase Open
Chromosome compaction is a key feature of mitosis and critical for accurate chromosome segregation. However, a precise quantitative analysis of chromosome geometry during mitotic progression is lacking. Here, we use volume electron microsc…
View article: The bromodomain inhibitor JQ1 is a molecular glue targeting centromeres
The bromodomain inhibitor JQ1 is a molecular glue targeting centromeres Open
Centromeres are the position on each chromosome that orchestrates the accurate partitioning of the genome during cell division. Centromere-dependent cell-cycle checkpoints are maintained by cancer cells to prevent catastrophic chromosome s…
View article: Epigenetic deregulation of lamina-associated domains in Hutchinson-Gilford progeria syndrome
Epigenetic deregulation of lamina-associated domains in Hutchinson-Gilford progeria syndrome Open
Background Hutchinson-Gilford progeria syndrome (HGPS) is a progeroid disease characterized by the early onset of age-related phenotypes including arthritis, loss of body fat and hair, and atherosclerosis. Cells from affected individuals e…
View article: Centromeric RNA and Its Function at and Beyond Centromeric Chromatin
Centromeric RNA and Its Function at and Beyond Centromeric Chromatin Open
The most fundamental region of the chromosome for maintaining accurate genome segregation and stability is the centromeric chromatin [1,2]. In this review, we will focus on centromere-derived RNAs (cenRNAs), a crucial component of centrome…
View article: Localization of Drosophila CENP-A to non-centromeric sites depends on the NuRD complex
Localization of Drosophila CENP-A to non-centromeric sites depends on the NuRD complex Open
Centromere function requires the presence of the histone H3 variant CENP-A in most eukaryotes. The precise localization and protein amount of CENP-A are crucial for correct chromosome segregation, and misregulation can lead to aneuploidy. …
View article: Investigating DNA supercoiling in eukaryotic genomes
Investigating DNA supercoiling in eukaryotic genomes Open
Supercoiling is a fundamental property of DNA, generated by polymerases and other DNA-binding proteins as a consequence of separating/bending the DNA double helix. DNA supercoiling plays a key role in gene expression and genome organizatio…
View article: Effects of DNA supercoiling on chromatin architecture
Effects of DNA supercoiling on chromatin architecture Open
View article: Effects of DNA supercoiling on chromatin architecture
Effects of DNA supercoiling on chromatin architecture Open
Disruptions in chromatin structure are necessary for the regulation of eukaryotic genomes, from remodelling of nucleosomes at the base pair level through to large-scale chromatin domains that are hundreds of kilobases in size. RNA polymera…
View article: Stochastic Model of Supercoiling-Dependent Transcription
Stochastic Model of Supercoiling-Dependent Transcription Open
We propose a stochastic model for gene transcription coupled to DNA supercoiling, where we incorporate the experimental observation that polymerases create supercoiling as they unwind the DNA helix and that these enzymes bind more favorabl…