Samuel E. Cooper
YOU?
Author Swipe
View article: Anxiety sensitivity and intolerance of uncertainty track distinct neurobehavioral dimensions of avoidance in anxiety-related psychopathology
Anxiety sensitivity and intolerance of uncertainty track distinct neurobehavioral dimensions of avoidance in anxiety-related psychopathology Open
Avoidance behavior is a prominent and impairing feature of anxiety, obsessive-compulsive, and trauma-related disorders (AD). A transdiagnostic approach to identifying the neural basis of avoidance is a promising avenue to elucidate the het…
View article: Neural correlates of human fear conditioning and sources of variability in 2199 individuals
Neural correlates of human fear conditioning and sources of variability in 2199 individuals Open
View article: How the nature of weak learning and retention interval affects behavioral tagging of episodic memory.
How the nature of weak learning and retention interval affects behavioral tagging of episodic memory. Open
Emotional experiences can promote memory consolidation of weakly learned events encoded around the same time. This memory enhancement through temporal convergence between a weak and strong event accords with the behavioral tagging hypothes…
View article: Neural correlates of human fear conditioning and sources of variability in 2199 individuals
Neural correlates of human fear conditioning and sources of variability in 2199 individuals Open
Pavlovian fear conditioning is a fundamental process in both health and disease. We investigated its neural correlates and sources of variability using harmonized functional magnetic resonance imaging data from 2,199 individuals across nin…
View article: Emotional Learning Selectively Distorts the Temporal Organization of Memory: a Quantitative Synthesis
Emotional Learning Selectively Distorts the Temporal Organization of Memory: a Quantitative Synthesis Open
Episodic memory allows us to remember when an event occurred by situating it within a coherent temporal context. Pavlovian fear conditioning, a widely studied form of associative emotional learning, creates implicit memories for neutral st…
View article: Augmenting Extinction with Counterconditioning Strengthens and Sustains Neural Safety Representations in PTSD
Augmenting Extinction with Counterconditioning Strengthens and Sustains Neural Safety Representations in PTSD Open
Because extinction forms the empirical foundation of exposure therapy, strategies to enhance extinction could lead to more effective interventions for post-traumatic stress disorder (PTSD). Here, we used functional MRI to compare immediate…
View article: Author Correction: Precision behavioral phenotyping as a strategy for uncovering the biological correlates of psychopathology
Author Correction: Precision behavioral phenotyping as a strategy for uncovering the biological correlates of psychopathology Open
View article: Integrating threat conditioning and the hierarchical taxonomy of psychopathology to advance the study of anxiety-related psychopathology.
Integrating threat conditioning and the hierarchical taxonomy of psychopathology to advance the study of anxiety-related psychopathology. Open
Theoretical and methodological research on threat conditioning provides important neuroscience-informed approaches to studying fear and anxiety. The threat conditioning framework is at the vanguard of physiological and neurobiological rese…
View article: Intolerance of uncertainty as a predictor of anxiety severity and trajectory during the COVID-19 pandemic
Intolerance of uncertainty as a predictor of anxiety severity and trajectory during the COVID-19 pandemic Open
View article: Semantic structures facilitate threat memory integration throughout the medial temporal lobe and medial prefrontal cortex
Semantic structures facilitate threat memory integration throughout the medial temporal lobe and medial prefrontal cortex Open
View article: Resetting the Hippocampal Buffer: A Neurocognitive Account of Psychedelic Therapy for Anxiety-Related Psychopathology
Resetting the Hippocampal Buffer: A Neurocognitive Account of Psychedelic Therapy for Anxiety-Related Psychopathology Open
Psychedelics (hallucinogenic 5-HT2A agonists such as psilocybin) are gaining recognition for their potential to treat a range of conditions, including anxiety-related psychopathology. Despite early promising results, the mechanisms by whic…
View article: Associations between anxiety-related traits and fear acquisition and extinction - an item-based content and meta-analysis [Stage 1 Registered Report]
Associations between anxiety-related traits and fear acquisition and extinction - an item-based content and meta-analysis [Stage 1 Registered Report] Open
Background: Dysregulated processing of fear and safety has been linked to anxietysymptoms and related traits, e.g., neuroticism, intolerance of uncertainty or negative emotionality. Yet, different studies focus on different aspects of fear…
View article: Causally Probing the Role of the Hippocampus in Fear Discrimination: A Precision Functional Mapping–Guided, Transcranial Magnetic Stimulation Study in Participants With Posttraumatic Stress Symptoms
Causally Probing the Role of the Hippocampus in Fear Discrimination: A Precision Functional Mapping–Guided, Transcranial Magnetic Stimulation Study in Participants With Posttraumatic Stress Symptoms Open
Overgeneralization is an associative process that reflects deficient discrimination of the fear cue from similar cues. In contrast, sensitization reflects nonassociative responding unrelated to fear cue similarity. Our results suggest that…
View article: Intolerance of uncertainty as a predictor of anxiety severity and trajectory during the COVID-19 pandemic
Intolerance of uncertainty as a predictor of anxiety severity and trajectory during the COVID-19 pandemic Open
Background: Efforts to identify risk and resilience factors for anxiety severity and course during the COVID-19 pandemic have focused primarily on demographic rather than psychological variables. Intolerance of uncertainty (IU), a transdia…
View article: Intolerance of Uncertainty as a Predictor of Anxiety Severity and Trajectory During the Covid-19 Pandemic
Intolerance of Uncertainty as a Predictor of Anxiety Severity and Trajectory During the Covid-19 Pandemic Open
View article: Integrating Threat Conditioning and the Hierarchical Taxonomy of Psychopathology (HiTOP) to Advance the Study of Anxiety-Related Psychopathology
Integrating Threat Conditioning and the Hierarchical Taxonomy of Psychopathology (HiTOP) to Advance the Study of Anxiety-Related Psychopathology Open
Theoretical and methodological research on threat conditioning provides important neuroscience-informed approaches to studying fear and anxiety. The conditioning framework is at the vanguard of physiological and neurobiological research in…
View article: Threat learning by proxy: Semantic structures facilitate emotional memory integration throughout the MTL and medial prefrontal cortex
Threat learning by proxy: Semantic structures facilitate emotional memory integration throughout the MTL and medial prefrontal cortex Open
Emotional experiences can profoundly impact our conceptual model of the world, modifying how we represent and remember a host of information even indirectly associated with that experience in the past. Yet, how a new emotional experience i…
View article: Insight enhances learning for incidental information. New evidence supports the insight memory advantage
Insight enhances learning for incidental information. New evidence supports the insight memory advantage Open
Research on creative problem-solving finds that solutions achieved via spontaneous insight (i.e., Aha! moment) are better remembered than solutions reached without this sense of epiphany, referred to as an ‘insight memory advantage.’ We hy…
View article: Precision behavioral phenotyping as a strategy for uncovering the biological correlates of psychopathology
Precision behavioral phenotyping as a strategy for uncovering the biological correlates of psychopathology Open
View article: Does social rigidity predict cognitive rigidity? Profiles of socio-cognitive polarization
Does social rigidity predict cognitive rigidity? Profiles of socio-cognitive polarization Open
View article: Causally probing the role of the human hippocampus in fear discrimination: A precision functional mapping guided TMS study in individuals with post-traumatic stress symptoms
Causally probing the role of the human hippocampus in fear discrimination: A precision functional mapping guided TMS study in individuals with post-traumatic stress symptoms Open
Fear overgeneralization is a potential pathogenic mechanism of anxiety-related disorders. A dominant model posits that overgeneralization occurs when the hippocampus fails to distinctly encode benign stimuli with insufficient similarity to…
View article: Counterconditioning reduces contextual renewal in a novel context but not in the acquisition context
Counterconditioning reduces contextual renewal in a novel context but not in the acquisition context Open
View article: Precision behavioral phenotyping as a strategy for uncovering the biological correlates of psychopathology
Precision behavioral phenotyping as a strategy for uncovering the biological correlates of psychopathology Open
Our capacity to measure diverse aspects of human biology in vivo has developed rapidly in the past decades, but the rate at which these techniques have generated translatable insights into the biology of psychopathological conditions has l…
View article: Pattern analysis of neuroimaging data reveals novel insights on threat learning and extinction in humans
Pattern analysis of neuroimaging data reveals novel insights on threat learning and extinction in humans Open
View article: Does Social Rigidity predict Cognitive Rigidity? Profiles of Socio-Cognitive Polarization
Does Social Rigidity predict Cognitive Rigidity? Profiles of Socio-Cognitive Polarization Open
Recent research has investigated the relationship between rigid political ideologies and underlying cognitive functions, highlighting discrepancies on how different ‘cognitive styles’ are defined and measured in relation with different sha…
View article: A meta-analysis of conditioned fear generalization in anxiety-related disorders
A meta-analysis of conditioned fear generalization in anxiety-related disorders Open
View article: Test-Retest Reliability of Human Threat Conditioning and Generalization
Test-Retest Reliability of Human Threat Conditioning and Generalization Open
Given the increasing use of threat conditioning and generalization for clinical-translational research efforts, establishing test-retest reliability of these paradigms is necessary. Specifically, it is an empirical question whether the sam…
View article: Psychological Flexibility in South Sudanese Female Trauma Survivors in Uganda as a Mechanism for Change Within a Guided Self-Help Intervention
Psychological Flexibility in South Sudanese Female Trauma Survivors in Uganda as a Mechanism for Change Within a Guided Self-Help Intervention Open
Introduction: Acceptance and commitment therapy (ACT) has a rapidly developing evidence base, with few studies in the developing world or humanitarian context. A recent trial of a guided self-help intervention derived from ACT reported sig…
View article: Psychological Flexibility in South Sudanese Female Trauma Survivors in Uganda as a Mechanism for Change Within a Guided Self-Help Intervention
Psychological Flexibility in South Sudanese Female Trauma Survivors in Uganda as a Mechanism for Change Within a Guided Self-Help Intervention Open
Introduction: Acceptance and commitment therapy (ACT) has a rapidly developing evidence base, with few studies in the developing world or humanitarian context. A recent trial of a guided self-help intervention derived from ACT reported sig…
View article: A Meta-Analysis of Conditioned Fear Generalization in Anxiety-Related Disorders
A Meta-Analysis of Conditioned Fear Generalization in Anxiety-Related Disorders Open
Objective: Generalization of conditioned fear is adaptive in some situations but maladaptive when fear excessively generalizes to innocuous stimuli with incidental resemblance to a genuine threat cue. Recently, empirical interest in fear g…