Samuel E. Garfinkle
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View article: Machine learning enables <i>de novo</i> multi-epitope design of plasmodium falciparum circumsporozoite protein to target trimeric L9 antibody
Machine learning enables <i>de novo</i> multi-epitope design of plasmodium falciparum circumsporozoite protein to target trimeric L9 antibody Open
Currently approved vaccines for the prevention of malaria provide only partial protection against disease, due to high variability in the quality of induced antibodies. These vaccines present the unstructured central repeat region, as well…
View article: Structural engineering of stabilized, expanded epitope nanoparticle vaccines for HPV
Structural engineering of stabilized, expanded epitope nanoparticle vaccines for HPV Open
Oncogenic forms of HPV account for 4.5% of the global cancer burden worldwide. This includes cervical, vaginal, vulvar, penile, and anal cancers, as well as head and neck cancers. As such, there is an urgent need to develop effective thera…
View article: Discovery of lirafugratinib (RLY-4008), a highly selective irreversible small-molecule inhibitor of FGFR2
Discovery of lirafugratinib (RLY-4008), a highly selective irreversible small-molecule inhibitor of FGFR2 Open
Fibroblast growth factor receptor (FGFR) kinase inhibitors have been shown to be effective in the treatment of intrahepatic cholangiocarcinoma and other advanced solid tumors harboring FGFR2 alterations, but the toxicity of these drugs fre…
View article: Structural principles of peptide-centric chimeric antigen receptor recognition guide therapeutic expansion
Structural principles of peptide-centric chimeric antigen receptor recognition guide therapeutic expansion Open
Peptide-centric chimeric antigen receptors (PC-CARs) recognize oncoprotein epitopes displayed by cell-surface human leukocyte antigens (HLAs) and offer a promising strategy for targeted cancer therapy. We have previously developed a PC-CAR…
View article: Structural principles of peptide-centric Chimeric Antigen Receptor recognition guide therapeutic expansion
Structural principles of peptide-centric Chimeric Antigen Receptor recognition guide therapeutic expansion Open
Peptide-Centric Chimeric Antigen Receptors (PC-CARs), which recognize oncoprotein epitopes displayed by human leukocyte antigens (HLAs) on the cell surface, offer a promising strategy for targeted cancer therapy 1 . We have previously deve…
View article: An Asymmetric sp3–sp3 Cross-Electrophile Coupling Using Biocatalysis
An Asymmetric sp3–sp3 Cross-Electrophile Coupling Using Biocatalysis Open
The catalytic asymmetric construction of Csp3–Csp3 bonds remains one of the foremost challenges in organic synthesis. Metal-catalyzed cross-electrophile couplings have emerged as a powerful tool for C–C bond formation. However, these catal…
View article: Photoexcitation of flavoenzymes enables a stereoselective radical cyclization
Photoexcitation of flavoenzymes enables a stereoselective radical cyclization Open
Light teaches (co)enzymes new tricks Light is widely used in organic synthesis to excite electrons in a substrate or catalyst, opening up reactive pathways to a desired product. Biology uses light sparingly in this way, but coenzymes such …