Sam E. Williams
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View article: BG04 (P063) Marked changes in the skin lipidome as we age are associated with reduced skin barrier function and can be rescued by topical therapy with physiologic lipids
BG04 (P063) Marked changes in the skin lipidome as we age are associated with reduced skin barrier function and can be rescued by topical therapy with physiologic lipids Open
As we age the integrity of our skin declines and it becomes increasingly prone to xerosis, especially in people with a history of atopic dermatitis (AD). We set out to investigate whether changes in the stratum corneum (SC) lipidome contri…
View article: P063 Marked changes in the skin lipidome as we age are associated with reduced skin barrier function and can be rescued by topical therapy with physiologic lipids
P063 Marked changes in the skin lipidome as we age are associated with reduced skin barrier function and can be rescued by topical therapy with physiologic lipids Open
As we age the integrity of our skin declines and it becomes increasingly prone to xerosis, especially in people with a history of atopic dermatitis (AD). We set out to investigate whether changes in the stratum corneum (SC) lipidome contri…
View article: antiSMASH 8.0: extended gene cluster detection capabilities and analyses of chemistry, enzymology, and regulation
antiSMASH 8.0: extended gene cluster detection capabilities and analyses of chemistry, enzymology, and regulation Open
Microorganisms synthesize small bioactive compounds through their secondary or specialized metabolism. Those compounds play an important role in microbial interactions and soil health, but are also crucial for the development of pharmaceut…
View article: Complete genome sequences of two actinomycetes containing abyssomicin-like gene clusters: <i>Kutzneria buriramensis</i> DSM 45791 and <i>Streptomyces</i> sp. NL15-2K
Complete genome sequences of two actinomycetes containing abyssomicin-like gene clusters: <i>Kutzneria buriramensis</i> DSM 45791 and <i>Streptomyces</i> sp. NL15-2K Open
Here, we report the resequencing, assembly, and annotation of two actinomycete genomes containing abyssomicin gene clusters. Kutzneria buriramensis DSM 45791 with a circular chromosome of 11,681,598 bp and 4 circular plasmids (14,175–207,5…
View article: Diversity and structure of the deep-sea sponge microbiome in the equatorial Atlantic Ocean
Diversity and structure of the deep-sea sponge microbiome in the equatorial Atlantic Ocean Open
Sponges (phylum Porifera) harbour specific microbial communities that drive the ecology and evolution of the host. Understanding the structure and dynamics of these communities is emerging as a primary focus in marine microbial ecology res…
View article: Maramycin, a cytotoxic isoquinolinequinone terpenoid produced through heterologous expression of a bifunctional indole prenyltransferase /tryptophan indole-lyase in<i>S. albidoflavus</i>
Maramycin, a cytotoxic isoquinolinequinone terpenoid produced through heterologous expression of a bifunctional indole prenyltransferase /tryptophan indole-lyase in<i>S. albidoflavus</i> Open
Isoquinolinequinones represent an important family of natural alkaloids with profound biological activities. Heterologous expression of a rare bifunctional indole prenyltransferase /tryptophan indole-lyase enzyme from Streptomyces mirabili…
View article: Diversity and structure of the deep-sea sponge microbiome in the equatorial Atlantic Ocean
Diversity and structure of the deep-sea sponge microbiome in the equatorial Atlantic Ocean Open
Sponges (phylum Porifera) harbour specific microbial communities that drive the ecology and evolution of the host. Understanding the structure and dynamics of these communities is emerging as a primary focus in marine microbial ecology res…
View article: Interrogation of an Enzyme Library Reveals the Catalytic Plasticity of Naturally Evolved [4+2] Cyclases
Interrogation of an Enzyme Library Reveals the Catalytic Plasticity of Naturally Evolved [4+2] Cyclases Open
Stereoselective carbon‐carbon bond forming reactions are quintessential transformations in organic synthesis. One example is the Diels‐Alder reaction, a [4+2] cycloaddition between a conjugated diene and a dienophile to form cyclohexenes. …
View article: Discovery and biosynthetic assessment of 'Streptomyces ortus' sp. nov. isolated from a deep-sea sponge
Discovery and biosynthetic assessment of 'Streptomyces ortus' sp. nov. isolated from a deep-sea sponge Open
The deep sea is known to host novel bacteria with the potential to produce a diverse array of undiscovered natural products. Thus, understanding these bacteria is of broad interest in ecology and could also underpin applied drug discovery,…
View article: Correction: Back et al. A New Micromonospora Strain with Antibiotic Activity Isolated from the Microbiome of a Mid-Atlantic Deep-Sea Sponge. Mar. Drugs 2021, 19, 105
Correction: Back et al. A New Micromonospora Strain with Antibiotic Activity Isolated from the Microbiome of a Mid-Atlantic Deep-Sea Sponge. Mar. Drugs 2021, 19, 105 Open
After publication of this article [...]
View article: Discovery and biosynthetic assessment of<i>Streptomyces ortus</i>sp nov. isolated from a deep-sea sponge
Discovery and biosynthetic assessment of<i>Streptomyces ortus</i>sp nov. isolated from a deep-sea sponge Open
The deep sea is known to host novel bacteria with the potential to produce a diverse array of undiscovered natural products. Understanding these bacteria is thus of broad interest in ecology and could also underpin applied drug discovery, …
View article: MIBiG 3.0: a community-driven effort to annotate experimentally validated biosynthetic gene clusters
MIBiG 3.0: a community-driven effort to annotate experimentally validated biosynthetic gene clusters Open
With an ever-increasing amount of (meta)genomic data being deposited in sequence databases, (meta)genome mining for natural product biosynthetic pathways occupies a critical role in the discovery of novel pharmaceutical drugs, crop protect…
View article: A New Micromonospora Strain with Antibiotic Activity Isolated from the Microbiome of a Mid-Atlantic Deep-Sea Sponge
A New Micromonospora Strain with Antibiotic Activity Isolated from the Microbiome of a Mid-Atlantic Deep-Sea Sponge Open
To tackle the growing problem of antibiotic resistance, it is essential to identify new bioactive compounds that are effective against resistant microbes and safe to use. Natural products and their derivatives are, and will continue to be,…
View article: 2 The extremophilic pharmacy: drug discovery at the limits of life
2 The extremophilic pharmacy: drug discovery at the limits of life Open
[No abstract]
View article: The Bristol Sponge Microbiome Collection: A Unique Repository of Deep-Sea Microorganisms and Associated Natural Products
The Bristol Sponge Microbiome Collection: A Unique Repository of Deep-Sea Microorganisms and Associated Natural Products Open
The deep ocean is the largest habitat for life on Earth, though the microorganisms that occupy this unique environmental niche remain largely unexplored. Due to the significant logistical and operational challenges associated with accessin…
View article: Marine transport infrastructure development in Moreton Bay: Dredging, monitoring and future directions
Marine transport infrastructure development in Moreton Bay: Dredging, monitoring and future directions Open
Paper contribution to the Moreton Bay (Quandamooka) & Catchment eBook available on www.moretonbayfoundation.org.