Samuel Furse
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View article: Systemic analyses show that the biosynthesis and spatial distribution of fatty acids, triglycerides and lipids differed in male and female mice and humans
Systemic analyses show that the biosynthesis and spatial distribution of fatty acids, triglycerides and lipids differed in male and female mice and humans Open
Recent work has shown that the prevalence and character of metabolic diseases differs between male and female mammals. This strongly suggests that the control mechanisms that govern, for example lipid metabolism, differ between the sexes. …
View article: Pollen Diet and Sterol Provisioning Differentially Affected Larval Development in a Generalist Solitary Bee
Pollen Diet and Sterol Provisioning Differentially Affected Larval Development in a Generalist Solitary Bee Open
Pollen sterols are essential micronutrients for bees as membrane components, hormone precursors and gene regulation. Sterols vary among plant species; therefore, bee development may be influenced by or adapted to specific pollen diets. To …
View article: Systemic analysis shows that cold exposure modulates triglyceride accumulation and phospholipid distribution in mice
Systemic analysis shows that cold exposure modulates triglyceride accumulation and phospholipid distribution in mice Open
Environmental exposure to cold is increasingly being associated with changes in metabolism. We developed and tested the hypothesis that exposure to cold drives systemic effects in lipid metabolism. Specifically, (i) that energy storage and…
View article: A co-ordinated transcriptional programme in the maternal liver supplies long chain polyunsaturated fatty acids to the conceptus using phospholipids
A co-ordinated transcriptional programme in the maternal liver supplies long chain polyunsaturated fatty acids to the conceptus using phospholipids Open
The long and very long chain polyunsaturated fatty acids (LC-PUFAs) are preferentially transported by the mother to the fetus. Failure to supply LC-PUFAs is strongly linked with stillbirth, fetal growth restriction, and impaired neurodevel…
View article: Systemic analysis of lipid metabolism from individuals to multi-organism systems
Systemic analysis of lipid metabolism from individuals to multi-organism systems Open
Complete pipeline for system-level of biological systems, from indivituals to ecosystems, using only metabolite data.
View article: Sterol and lipid metabolism in bees
Sterol and lipid metabolism in bees Open
View article: Metabolomic insights into maternal and neonatal complications in pregnancies affected by type 1 diabetes
Metabolomic insights into maternal and neonatal complications in pregnancies affected by type 1 diabetes Open
View article: Sterol composition in plants is specific to pollen, leaf, pollination and pollinator
Sterol composition in plants is specific to pollen, leaf, pollination and pollinator Open
View article: A co-ordinated transcriptional programme in the maternal liver supplies LC-PUFAs to the conceptus using phospholipids
A co-ordinated transcriptional programme in the maternal liver supplies LC-PUFAs to the conceptus using phospholipids Open
Essential fatty acids (EFAs) and their derivatives, the long and very long chain polyunsaturated fatty acids (LC-PUFAs), are preferentially transported by the mother to the fetus. Failure to supply EFAs is strongly linked with stillbirth, …
View article: Towards Precision Medicine in Gestational Diabetes: Pathophysiology and Glycemic Patterns in Pregnant Women With Obesity
Towards Precision Medicine in Gestational Diabetes: Pathophysiology and Glycemic Patterns in Pregnant Women With Obesity Open
Aims Precision medicine has revolutionized our understanding of type 1 diabetes and neonatal diabetes but has yet to improve insight into gestational diabetes mellitus (GDM), the most common obstetric complication and strongly linked to ob…
View article: Characterisation of the Paternal Influence on Intergenerational Offspring Cardiac and Brain Lipid Homeostasis in Mice
Characterisation of the Paternal Influence on Intergenerational Offspring Cardiac and Brain Lipid Homeostasis in Mice Open
There is growing evidence that poor paternal diet at the time of conception increase the risk of offspring developing a range of non-communicable metabolic diseases, such as obesity, diabetes and cardiovascular disease, in adulthood. We hy…
View article: The role of the tryptophan-NAD + pathway in a mouse model of severe malnutrition induced liver dysfunction
The role of the tryptophan-NAD + pathway in a mouse model of severe malnutrition induced liver dysfunction Open
Mortality in children with severe malnutrition is strongly related to signs of metabolic dysfunction, such as hypoglycemia. Lower circulating tryptophan levels in children with severe malnutrition suggest a possible disturbance in the tryp…
View article: Relative Abundance of Lipid Metabolites in Spermatozoa across Three Compartments
Relative Abundance of Lipid Metabolites in Spermatozoa across Three Compartments Open
Male fertility, as manifest by the quantity and progressive motility of spermatozoa, is negatively impacted by obesity, dyslipidaemia and metabolic disease. However, the relative distribution of lipids in spermatozoa and the two compartmen…
View article: Lipid profiling analyses from mouse models and human infants
Lipid profiling analyses from mouse models and human infants Open
This protocol outlines a translational lipidomic approach to discover lipid biomarkers that could predict morphometric body and histological organ measurements (e.g., weight and adiposity gains) during specific stages of life (e.g., early …
View article: Paternal low protein diet perturbs inter-generational metabolic homeostasis in a tissue-specific manner in mice
Paternal low protein diet perturbs inter-generational metabolic homeostasis in a tissue-specific manner in mice Open
View article: Lipid metabolism is dysregulated in a mouse model of diabetes
Lipid metabolism is dysregulated in a mouse model of diabetes Open
View article: Variants in mitochondrial amidoxime reducing component 1 and hydroxysteroid 17‐beta dehydrogenase 13 reduce severity of nonalcoholic fatty liver disease in children and suppress fibrotic pathways through distinct mechanisms
Variants in mitochondrial amidoxime reducing component 1 and hydroxysteroid 17‐beta dehydrogenase 13 reduce severity of nonalcoholic fatty liver disease in children and suppress fibrotic pathways through distinct mechanisms Open
Genome‐wide association studies in adults have identified variants in hydroxysteroid 17‐beta dehydrogenase 13 ( HSD17B13 ) and mitochondrial amidoxime reducing component 1 ( MTARC1 ) as protective against nonalcoholic fatty liver disease (…
View article: Altered Lipid Metabolism in Obese Women With Gestational Diabetes and Associations With Offspring Adiposity
Altered Lipid Metabolism in Obese Women With Gestational Diabetes and Associations With Offspring Adiposity Open
Context Gestational diabetes (GDM) affects 20 million women/year worldwide and is associated with childhood obesity. Infants of affected mothers have increased adiposity from birth, which leads to obesity in later life. However, it remains…
View article: Comparison of the Lipidomic Signature of Fatty Liver in Children and Adults
Comparison of the Lipidomic Signature of Fatty Liver in Children and Adults Open
Objective: Non‐alcoholic fatty liver disease (NAFLD) is an increasingly common condition in children characterised by insulin resistance and altered lipid metabolism. Affected patients are at increased risk of cardiovascular disease (CVD) …
View article: A mouse model of gestational diabetes shows dysregulated lipid metabolism post-weaning, after return to euglycaemia
A mouse model of gestational diabetes shows dysregulated lipid metabolism post-weaning, after return to euglycaemia Open
View article: Dietary PUFAs drive diverse system-level changes in lipid metabolism
Dietary PUFAs drive diverse system-level changes in lipid metabolism Open
View article: Paternal nutritional programming of lipid metabolism is propagated through sperm and seminal plasma
Paternal nutritional programming of lipid metabolism is propagated through sperm and seminal plasma Open
View article: Maternal diet-induced obesity during pregnancy alters lipid supply to mouse E18.5 fetuses and changes the cardiac tissue lipidome in a sex-dependent manner
Maternal diet-induced obesity during pregnancy alters lipid supply to mouse E18.5 fetuses and changes the cardiac tissue lipidome in a sex-dependent manner Open
Maternal obesity during pregnancy has immediate and long-term detrimental effects on the offspring heart. In this study, we characterized the cardiac and circulatory lipid profiles in late gestation E18.5 fetuses of diet-induced obese preg…
View article: Author response: Maternal diet-induced obesity during pregnancy alters lipid supply to mouse E18.5 fetuses and changes the cardiac tissue lipidome in a sex-dependent manner
Author response: Maternal diet-induced obesity during pregnancy alters lipid supply to mouse E18.5 fetuses and changes the cardiac tissue lipidome in a sex-dependent manner Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Maternal obesity durin…
View article: A pipeline for making 31P NMR accessible for small- and large-scale lipidomics studies
A pipeline for making 31P NMR accessible for small- and large-scale lipidomics studies Open
View article: Lipid Metabolism Is Dysregulated before, during and after Pregnancy in a Mouse Model of Gestational Diabetes
Lipid Metabolism Is Dysregulated before, during and after Pregnancy in a Mouse Model of Gestational Diabetes Open
The aim of the current study was to test the hypothesis that maternal lipid metabolism was modulated during normal pregnancy and that these modulations are altered in gestational diabetes mellitus (GDM). We tested this hypothesis using an …
View article: The biosynthesis of phospholipids is linked to the cell cycle in a model eukaryote
The biosynthesis of phospholipids is linked to the cell cycle in a model eukaryote Open
View article: Maternal diet-induced obesity during pregnancy alters lipid supply to fetuses and changes the cardiac tissue lipidome in a sex-dependent manner
Maternal diet-induced obesity during pregnancy alters lipid supply to fetuses and changes the cardiac tissue lipidome in a sex-dependent manner Open
Maternal obesity during pregnancy has immediate and long-term detrimental effects on the offspring heart. In this study, we characterized the cardiac and circulatory lipid profiles in fetuses of diet-induced obese pregnant mice and establi…
View article: A Pipeline for Making 31P NMR Accessible for Small- and Large-Scale Lipidomics Studies
A Pipeline for Making 31P NMR Accessible for Small- and Large-Scale Lipidomics Studies Open
Detailed molecular analysis is of increasing importance in research into the regulation of biochemical pathways, organismal growth and disease. Lipidomics in particular is increasingly sought after as it provides insight into molecular spe…
View article: A Pipeline for Making 31P NMR Accessible for Small- and Large-Scale Lipidomics Studies
A Pipeline for Making 31P NMR Accessible for Small- and Large-Scale Lipidomics Studies Open
Detailed molecular analysis is of increasing importance in research into the regulation of biochemical pathways, organismal growth and disease. Lipidomics in particular is increasingly sought after as it provides insight into molecular spe…