Samuel G. Huete
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View article: Revisiting oxygen toxicity: evolution and adaptation to superoxide in a SOD-deficient bacterial pathogen
Revisiting oxygen toxicity: evolution and adaptation to superoxide in a SOD-deficient bacterial pathogen Open
Dioxygen (O 2 ) is vital for aerobic life, but its utilization leads to the inevitable production of superoxide, a toxic oxidant. The prevailing theory of oxygen toxicity postulates that superoxide-scavenging enzymes (SOSEs), such as super…
View article: Linking genomic evolutionary transitions to ecological phenotypic adaptations in Spirochaetes
Linking genomic evolutionary transitions to ecological phenotypic adaptations in Spirochaetes Open
Understanding the genetic basis of ecological adaptation is a fundamental challenge of evolutionary biology, often limited by the availability of diverse and curated datasets. Spirochaetes are widely distributed, ancient bacteria found in …
View article: Revisiting oxygen toxicity: evolution and adaptation to superoxide in a SOD-deficient bacterial pathogen
Revisiting oxygen toxicity: evolution and adaptation to superoxide in a SOD-deficient bacterial pathogen Open
Defenses against oxidants are crucial for the virulence of pathogens, with superoxide scavenging enzymes (SOSEs) playing a vital role for most aerobes. However, our knowledge of superoxide adaptation primarily stems from the study of SOSE-…
View article: Inter-species Transcriptomic Analysis Reveals a Constitutive Adaptation Against Oxidative Stress for the Highly Virulent <i>Leptospira</i> Species
Inter-species Transcriptomic Analysis Reveals a Constitutive Adaptation Against Oxidative Stress for the Highly Virulent <i>Leptospira</i> Species Open
Transcriptomic analyses across large scales of evolutionary distance have great potential to shed light on regulatory evolution but are complicated by difficulties in establishing orthology and limited availability of accessible software. …
View article: Pan-species transcriptomic analysis reveals a constitutive adaptation against oxidative stress for the highly virulent<i>Leptospira</i>species
Pan-species transcriptomic analysis reveals a constitutive adaptation against oxidative stress for the highly virulent<i>Leptospira</i>species Open
Different environments exert selective pressures on bacterial populations, favoring individuals with particular genetic traits that are well-suited for survival in those conditions. Evolutionary mechanisms such as natural selection have, t…
View article: The Arsenal of Leptospira Species against Oxidants
The Arsenal of Leptospira Species against Oxidants Open
Reactive oxygen species (ROS) are byproducts of oxygen metabolism produced by virtually all organisms living in an oxic environment. ROS are also produced by phagocytic cells in response to microorganism invasion. These highly reactive mol…
View article: The oxidative stress response of pathogenic Leptospira is controlled by two peroxide stress regulators which putatively cooperate in controlling virulence
The oxidative stress response of pathogenic Leptospira is controlled by two peroxide stress regulators which putatively cooperate in controlling virulence Open
Pathogenic Leptospira are the causative agents of leptospirosis, the most widespread zoonotic infectious disease. Leptospirosis is a potentially severe and life-threatening emerging disease with highest burden in sub-tropical areas and imp…
View article: The oxidative stress response of pathogenic <i>Leptospira</i> is controlled by two peroxide stress regulators which putatively cooperate in controlling virulence
The oxidative stress response of pathogenic <i>Leptospira</i> is controlled by two peroxide stress regulators which putatively cooperate in controlling virulence Open
Pathogenic Leptospira are the causative agents of leptospirosis, the most widespread zoonotic infectious disease. Leptospirosis is a potentially severe and life-threatening emerging disease with highest burden in sub-tropical areas and imp…
View article: A case report: insights into reducing plastic waste in a microbiology laboratory
A case report: insights into reducing plastic waste in a microbiology laboratory Open
Single-use plastics have often replaced more sustainable materials in microbiology laboratories. Keeping in mind that one of the objectives of the United Nations Sustainable Development Goals is responsible consumption and production, we w…
View article: The transcriptional response of pathogenic Leptospira to peroxide reveals new defenses against infection-related oxidative stress
The transcriptional response of pathogenic Leptospira to peroxide reveals new defenses against infection-related oxidative stress Open
Pathogenic Leptospira spp. are the causative agents of the waterborne zoonotic disease leptospirosis. Leptospira are challenged by numerous adverse conditions, including deadly reactive oxygen species (ROS), when infecting their hosts. Wit…
View article: The adaptive transcriptional response of pathogenic<i>Leptospira</i>to peroxide reveals new defenses against infection-related oxidative stress
The adaptive transcriptional response of pathogenic<i>Leptospira</i>to peroxide reveals new defenses against infection-related oxidative stress Open
Pathogenic Leptospira spp. are the causative agents of the waterborne zoonotic disease leptospirosis. During infection, Leptospira are confronted with dramatic adverse environmental changes such as deadly reactive oxygen species (ROS). Wit…
View article: Improving the serodiagnosis of canine Leishmania infantum infection in geographical areas of Brazil with different disease prevalence
Improving the serodiagnosis of canine Leishmania infantum infection in geographical areas of Brazil with different disease prevalence Open
Serodiagnosis of Leishmania infantum infection in dogs relies on the detection of antibodies against leishmanial crude extracts or parasitic defined antigens. The expansion of canine leishmaniasis from geographical areas of Brazil i…