Samuel Gamble
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View article: Somatic evolution following cancer treatment in normal tissue
Somatic evolution following cancer treatment in normal tissue Open
The extent to which exogenous sources, including cancer treatment, contribute to somatic evolution in normal tissue remains unclear. Here we used high-depth duplex sequencing 1 (more than 30,000× coverage) to analyse 168 cancer-free sample…
View article: Clonal driver neoantigen loss under EGFR TKI and immune selection pressures
Clonal driver neoantigen loss under EGFR TKI and immune selection pressures Open
Neoantigen vaccines are under investigation for various cancers, including epidermal growth factor receptor ( EGFR )-driven lung cancers 1,2 . We tracked the phylogenetic history of an EGFR mutant lung cancer treated with erlotinib, osimer…
View article: A pan-cancer single-cell RNA-seq atlas of intratumoral B cells
A pan-cancer single-cell RNA-seq atlas of intratumoral B cells Open
Tumor-infiltrating B cells play a significant role in tumor development, progression, and prognosis, yet a comprehensive classification system is lacking. To address this gap, we present a pan-cancer single-cell RNA sequencing (scRNA-seq) …