Samuel H.H. Chan
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View article: Age-related inflammatory changes and perineuronal net dynamics: implications for neurodegenerative disorders
Age-related inflammatory changes and perineuronal net dynamics: implications for neurodegenerative disorders Open
Background Healthy aging alone can lead to cognitive decline, decreased brain size, protein aggregation, accumulation of senescent cells and neuroinflammation. Furthermore, age is the primary risk factor for several neurodegenerative disor…
View article: UK Real-World Evidence of Using Durvalumab Plus Cisplatin and Gemcitabine in Advanced Biliary Tract Cancer via an Early Access Scheme
UK Real-World Evidence of Using Durvalumab Plus Cisplatin and Gemcitabine in Advanced Biliary Tract Cancer via an Early Access Scheme Open
Background: Durvalumab (anti-PD-L1) in combination with gemcitabine and cisplatin has become the first-line treatment for patients with locally advanced, surgically unresectable, or metastatic biliary tract cancer, following the survival b…
View article: Effectiveness and safety of antibiotics in kidney transplant recipients with asymptomatic bacteriuria: a systematic review and meta-analysis of randomized controlled trials
Effectiveness and safety of antibiotics in kidney transplant recipients with asymptomatic bacteriuria: a systematic review and meta-analysis of randomized controlled trials Open
Background Asymptomatic bacteriuria (ASB) is generally systematically screened and treated with antibiotics in kidney transplant recipients (KTRs). We aimed to explore the role of antibiotic therapy in management of ASB in KTRs. Methods Ra…
View article: SINGLE CELL LANDSCAPE OF MULTICENTRIC CASTLEMAN DISEASE IN IDENTICAL TWINS
SINGLE CELL LANDSCAPE OF MULTICENTRIC CASTLEMAN DISEASE IN IDENTICAL TWINS Open
Idiopathic Multicentric Castleman Disease (iMCD) is a rare IL-6-driven hematological disorder characterized by systemic lymphadenopathy, elevated immunoglobulin levels, and prominent plasmacytosis in the bone marrow and lymph nodes. An unu…
View article: Immunotherapy-related adverse events in real-world patients with advanced non-small cell lung cancer on chemoimmunotherapy: a Spinnaker study sub-analysis
Immunotherapy-related adverse events in real-world patients with advanced non-small cell lung cancer on chemoimmunotherapy: a Spinnaker study sub-analysis Open
Background The Spinnaker study evaluated survival outcomes and prognostic factors in patients with advanced non-small-cell lung cancer receiving first-line chemoimmunotherapy in the real world. This sub-analysis assessed the immunotherapy-…
View article: Postoperative Stroke after Spinal Anesthesia and Responses of Carotid or Cerebral Blood Flow and Baroreflex Functionality to Spinal Bupivacaine in Rats
Postoperative Stroke after Spinal Anesthesia and Responses of Carotid or Cerebral Blood Flow and Baroreflex Functionality to Spinal Bupivacaine in Rats Open
Spinal anesthesia is generally accepted as an effective and safe practice. Three rare incidents of postoperative cerebral infarction after surgery under spinal anesthesia prompted us to assess whether spinal bupivacaine may compromise caro…
View article: Understanding Post-Employment Obligations of Confidence and Confidentiality in Compilations of Data
Understanding Post-Employment Obligations of Confidence and Confidentiality in Compilations of Data Open
This article closely examinesn two specific areas in the law of confidence. The first concerns erstwhile employer-employee relationships and the various obligations of confidentiality that may bind an employee-including individuals who fin…
View article: Postoperative Stroke in Patients After Spinal Anesthesia and Disparate Response Patterns of Carotid or Cerebral Blood Flow and Baroreflex Functionality to Spinal Bupivacaine in Rats
Postoperative Stroke in Patients After Spinal Anesthesia and Disparate Response Patterns of Carotid or Cerebral Blood Flow and Baroreflex Functionality to Spinal Bupivacaine in Rats Open
Spinal anesthesia is generally accepted as an effective and safe practice. Three rare incidents of postoperative cerebral infarction after surgery under spinal anesthesia with bupivacaine prompted us to assess whether spinal bupivacaine ma…
View article: Causal contribution of malignancy to anomalous baroreflex functionality in patients with cancer: An overlooked aspect of cardio-oncology
Causal contribution of malignancy to anomalous baroreflex functionality in patients with cancer: An overlooked aspect of cardio-oncology Open
The current trend in cardio-oncology places major emphasis on circulatory toxicity induced by cancer therapy. Whether malignancy itself is a direct contributing factor to cardiovascular dysfunctions and baroreflex dysregulation in patients…
View article: Patient and surgeon perspectives on the American Thyroid Association (ATA) 2015 & British Thyroid Association (BTA) 2014 guidelines in the management of “Low-Risk” Thyroid Cancers (LRDTCs): Two sides of the coin
Patient and surgeon perspectives on the American Thyroid Association (ATA) 2015 & British Thyroid Association (BTA) 2014 guidelines in the management of “Low-Risk” Thyroid Cancers (LRDTCs): Two sides of the coin Open
Objectives: To investigate how surgeons interpret the ATA 2015 and BTA 2014 guidelines for low risk well differentiated thyroid cancers (LRDTCs) and how they impact patient experiences across the UK. Design: Three nationally disseminated a…
View article: Supplementary Material for: Systematic Review of Recurrence Rate after Hemithyroidectomy for Low-Risk Well-Differentiated Thyroid Cancer
Supplementary Material for: Systematic Review of Recurrence Rate after Hemithyroidectomy for Low-Risk Well-Differentiated Thyroid Cancer Open
Background: Surgical extent in the management of well-differentiated thyroid cancer (DTC) remains a recurrent subject of debate. This is especially relevant in low-risk DTC of 1–4 cm, which represent the majority of new thyroid cancer diag…
View article: Reinstatement of respiratory sinus arrhythmia as a therapeutic target of cardiac pacing for the management of heart failure
Reinstatement of respiratory sinus arrhythmia as a therapeutic target of cardiac pacing for the management of heart failure Open
Heart failure (HF) has become a global pandemic with an anticipated increase in prevalence because of the ageing population worldwide. HF is a complex clinical syndrome with many aetiological causes including, among others, coronary artery…
View article: Activation of spinal nociceptin receptors induces cardiovascular depression and antinociception in an independent manner in mice
Activation of spinal nociceptin receptors induces cardiovascular depression and antinociception in an independent manner in mice Open
Activation of thoracic spinal NOP in ICR and C57BL/6 mice induces blood pressure and heart rate by decreasing the sympathetic outflow of both arms of the baroreflex arc to the blood vessels and the heart, and the antinociceptive responses …
View article: Baroreflex functionality in the eye of diffusion tensor imaging
Baroreflex functionality in the eye of diffusion tensor imaging Open
By applying diffusion tensor imaging (DTI) as a physiological tool to evaluate changes in functional connectivity between key brainstem nuclei in the baroreflex neural circuits of mice and rats, recent work has revealed several hitherto un…
View article: UNDERSTANDING BRAIN DEATH: INSIGHT FROM TRANSLATIONAL MEDICINE
UNDERSTANDING BRAIN DEATH: INSIGHT FROM TRANSLATIONAL MEDICINE Open
The role of the anterolateral ligament as a secondary restraint to the anterior cruciate ligament in controlling tibial internal rotation and pivot shift is greatly debated today because biomechanical studies lead to conflicting results. H…
View article: BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) AS AN ENDOGENOUS ANTIOXIDANT IN ANIMAL MODELS OF DISEASE
BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) AS AN ENDOGENOUS ANTIOXIDANT IN ANIMAL MODELS OF DISEASE Open
The effects of Jobelyn® (JB) on neurological deficits and biochemical alterations associated with ischemic stroke induced by bilateral common carotid artery occlusion (BCCAO) in rats were investigated in this study. Male Wistar rats were d…
View article: Differential clinical impacts of oxidative stress and nitrosative stress: Therapeutic implications
Differential clinical impacts of oxidative stress and nitrosative stress: Therapeutic implications Open
The central theme of this lecture is that oxidative stress and nitrosative stress bear differential clinical impact, and that therapeutic intervention is only achievable against pathophysiological, but not pathological conditions. Using as…
View article: Cadmium induces dose-dependent cardiovascular fates with differential underlying hemodynamic, neural and cellular mechanisms
Cadmium induces dose-dependent cardiovascular fates with differential underlying hemodynamic, neural and cellular mechanisms Open
Cadmium is a heavy metal and an environmental toxicant. Acute exposure to cadmium induces cardiovascular toxicity and mortality. This study aims at determining whether lethal or sub-lethal dose of cadmium induces cardiovascular toxicity on…
View article: Anomalous baroreflex functionality inherent in floxed and Cre-Lox mice: an overlooked physiological phenotype
Anomalous baroreflex functionality inherent in floxed and Cre-Lox mice: an overlooked physiological phenotype Open
The last two decades have seen the emergence of Cre-Lox recombination as one of the most powerful and versatile technologies for cell-specific genetic engineering of mammalian cells. Understandably, the primary concerns in the practice of …
View article: Mitochondria and Reactive Oxygen Species Contribute to Neurogenic Hypertension
Mitochondria and Reactive Oxygen Species Contribute to Neurogenic Hypertension Open
Beyond its primary role as fuel generators, mitochondria are engaged in a variety of cellular processes, including redox homeostasis. Mitochondrial dysfunction, therefore, may have a profound impact on high-energy-demanding organs such as …
View article: Sumoylation of IkB attenuates NF-kB-induced nitrosative stress at rostral ventrolateral medulla and cardiovascular depression in experimental brain death
Sumoylation of IkB attenuates NF-kB-induced nitrosative stress at rostral ventrolateral medulla and cardiovascular depression in experimental brain death Open
We conclude that sumoylation of IkB in the RVLM ameliorates the defunct brain stem cardiovascular regulation that underpins brain death in our experimental endotoxemia modal by reducing nitrosative stress via inhibition of IkB degradation …
View article: Dynamin‐Related Protein 1 Promotes Mitochondrial Fission and Contributes to The Hippocampal Neuronal Cell Death Following Experimental Status Epilepticus
Dynamin‐Related Protein 1 Promotes Mitochondrial Fission and Contributes to The Hippocampal Neuronal Cell Death Following Experimental Status Epilepticus Open
Summary Aims Prolonged seizure activity may result in mitochondrial dysfunction and lead to cell death in the hippocampus. Mitochondrial fission may occur in an early stage of neuronal cell death. This study examined the role of the mitoch…