Samuel Holvec
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View article: Translation initiation by the Kozak mRNA sequence is based on a conformational readout on the ribosome
Translation initiation by the Kozak mRNA sequence is based on a conformational readout on the ribosome Open
The recognition mechanism of Kozak mRNA, typically comprising purines in the - 3 and +4 positions flanking the AUG start codon, has remained enigmatic for decades. To address this fundamental function in eukaryotes during translation initi…
View article: Structure of the human 80S ribosome at 1.9 Å resolution – the molecular role of chemical modifications and ions in RNA
Structure of the human 80S ribosome at 1.9 Å resolution – the molecular role of chemical modifications and ions in RNA Open
Summary The ribosomal RNA of the human protein synthesis machinery comprises numerous chemical modifications that are introduced during ribosome biogenesis. We present the 1.9 Å resolution cryo-EM structure of the 80S human ribosome resolv…
View article: Targeting the Human 80S Ribosome in Cancer: From Structure to Function and Drug Design for Innovative Adjuvant Therapeutic Strategies
Targeting the Human 80S Ribosome in Cancer: From Structure to Function and Drug Design for Innovative Adjuvant Therapeutic Strategies Open
The human 80S ribosome is the cellular nucleoprotein nanomachine in charge of protein synthesis that is profoundly affected during cancer transformation by oncogenic proteins and provides cancerous proliferating cells with proteins and the…