Samuel Hwang
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View article: Biosafety assessment of engineered CCL20 locked dimers in vivo
Biosafety assessment of engineered CCL20 locked dimers in vivo Open
Immune dysregulation by aberrant chemokine production underlies many diseases. Targeting chemokine receptors with small molecule inverse agonists, antagonists, or neutralizing antibodies has proven challenging due to non-specific effects a…
View article: Role of ion channels in immune regulation of psoriasis
Role of ion channels in immune regulation of psoriasis Open
Psoriasis is a chronic inflammatory skin disease marked by abnormal keratinocyte growth, immune dysfunction, and a weakened skin barrier. Affecting 2-3% of the global population, it lowers quality of life and is linked to systemic conditio…
View article: Mechanobiology of neutrophil inflammasome signaling in psoriasis
Mechanobiology of neutrophil inflammasome signaling in psoriasis Open
While T cells play a prominent role, polymorphonuclear neutrophils (PMN) are also significant players in the pathogenesis of psoriasis. This review details the mechanobiology of PMN in the amplification of skin inflammation, a process ofte…
View article: Breakout Session and Report Back: Collaboration of Rheumatologists and Dermatologists for the Care of Patients With Psoriatic Disease
Breakout Session and Report Back: Collaboration of Rheumatologists and Dermatologists for the Care of Patients With Psoriatic Disease Open
Multidisciplinary care is essential for the management of patients with psoriatic disease (PsD), considering the great range of cutaneous and musculoskeletal symptoms and the potential for associated comorbidities and extraarticular manife…
View article: FGF1 Suppresses Allosteric Activation of β3 Integrins by FGF2: A Potential Mechanism of Anti-Inflammatory and Anti-Thrombotic Action of FGF1
FGF1 Suppresses Allosteric Activation of β3 Integrins by FGF2: A Potential Mechanism of Anti-Inflammatory and Anti-Thrombotic Action of FGF1 Open
Several inflammatory cytokines bind to the allosteric site (site 2) and allosterically activate integrins. Site 2 is also a binding site for 25-hydroxycholesterol, an inflammatory lipid mediator, and is involved in inflammatory signaling (…
View article: Topical treatment of tyrosine kinase 2 inhibitor through borneol-embedded hydrogel: Evaluation for preventive, therapeutic, and Recurrent management of psoriasis
Topical treatment of tyrosine kinase 2 inhibitor through borneol-embedded hydrogel: Evaluation for preventive, therapeutic, and Recurrent management of psoriasis Open
Psoriasis, an immune-mediated inflammatory skin disorder characterized by a chronically relapsing-remitting course, continues to be primarily managed through topical therapy. While oral administration of tyrosine kinase 2 inhibitors (TYK2i…
View article: Advancing Basic and Translational Science: Highlights From the Basic Science Workshop at the GRAPPA 2023 Annual Meeting
Advancing Basic and Translational Science: Highlights From the Basic Science Workshop at the GRAPPA 2023 Annual Meeting Open
Contemporary translational and clinical research advances in psoriatic disease (PsD) were highlighted at the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) 2023 annual meeting basic science workshop. This y…
View article: Reevaluating cholestasis: a case of PFIC3 diagnosed through whole genome sequencing after initial miss on cholestasis genetic panel
Reevaluating cholestasis: a case of PFIC3 diagnosed through whole genome sequencing after initial miss on cholestasis genetic panel Open
Progressive Familial Intrahepatic Cholestasis (PFIC) 3 is a genetic condition caused by disruption of transportation of bile acids across hepatocytes resulting in bile acid buildup leading to cholestasis, liver dysfunction, and potentially…
View article: FGF2 binds to the allosteric site (site 2) and activates integrin αIIbβ3 and FGF1 binds to site 2 but suppresses integrin activation by FGF2: A potential mechanism of anti-thrombotic action of FGF1
FGF2 binds to the allosteric site (site 2) and activates integrin αIIbβ3 and FGF1 binds to site 2 but suppresses integrin activation by FGF2: A potential mechanism of anti-thrombotic action of FGF1 Open
It has been believed that platelet integrin αIIbβ3 recognizes fibrinogen and several ECM proteins, and we recently showed that αIIbβ3 binds to several inflammatory cytokines (e.g., CCL5, and CXCL12), which are stored in platelet granules. …
View article: FGF2 binds to the allosteric site (site 2) and activates αvβ3 integrin and FGF1 binds to site 2 but suppresses integrin activation by FGF2: a potential mechanism of anti-inflammatory action of FGF1
FGF2 binds to the allosteric site (site 2) and activates αvβ3 integrin and FGF1 binds to site 2 but suppresses integrin activation by FGF2: a potential mechanism of anti-inflammatory action of FGF1 Open
FGF1 is known as an anti-inflammatory and has suppresses insulin resistance. Its homologue FGF2 is pro-inflammatory. Mechanism of FGF1’s anti-inflammatory action and FGF2’s pro-inflammatory action are unknown. Several inflammatory cytokine…
View article: Advances and Controversies in Our Understanding of Guttate and Plaque Psoriasis
Advances and Controversies in Our Understanding of Guttate and Plaque Psoriasis Open
Acute guttate psoriasis (AGP) is considered an uncommon variant of psoriasis (PsO), characterized as a widespread eruption of erythematous, psoriasiform papules, and plaques on the trunk, extremities, and scalp. Predisposing factors includ…
View article: GRAPPA 2021 Pilot Grant Award Reports
GRAPPA 2021 Pilot Grant Award Reports Open
The Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) pilot grant awards help support young researchers starting their careers while also encouraging them to develop a focus on psoriatic disease. In this brief…
View article: The Emerging Potential of Bile Acids as a Modulator of Psoriatic Inflammation
The Emerging Potential of Bile Acids as a Modulator of Psoriatic Inflammation Open
Background Bile acids (BAs) are cholesterol-based amphipathic surfactants that are most widely known for their contributions to lipid metabolism, but more recently have been increasingly recognized as a key signaling molecule in inflammato…
View article: Supplementary Figure 2 from A Locked, Dimeric CXCL12 Variant Effectively Inhibits Pulmonary Metastasis of CXCR4-Expressing Melanoma Cells Due to Enhanced Serum Stability
Supplementary Figure 2 from A Locked, Dimeric CXCL12 Variant Effectively Inhibits Pulmonary Metastasis of CXCR4-Expressing Melanoma Cells Due to Enhanced Serum Stability Open
PDF file, 36K, Representative raw Calcium flux data of Figure 1F and that of CXCR4-negative B16 cells with proteins.
View article: Supplementary Data from Leukocyte Heterogeneity in Pancreatic Ductal Adenocarcinoma: Phenotypic and Spatial Features Associated with Clinical Outcome
Supplementary Data from Leukocyte Heterogeneity in Pancreatic Ductal Adenocarcinoma: Phenotypic and Spatial Features Associated with Clinical Outcome Open
File contains supplementary Materials & Methods, supplementary References, and Supplementary Tables S1-S10.
View article: Figure S2 from Leukocyte Heterogeneity in Pancreatic Ductal Adenocarcinoma: Phenotypic and Spatial Features Associated with Clinical Outcome
Figure S2 from Leukocyte Heterogeneity in Pancreatic Ductal Adenocarcinoma: Phenotypic and Spatial Features Associated with Clinical Outcome Open
Figure S2 is related to Figure 2 and contains data from global unsupervised clustering analysis of treatment naive PDACs. Data include cell densities of leukocyte subpopulations by cluster, quantification of tissue area evaluated in patien…
View article: Data from A Locked, Dimeric CXCL12 Variant Effectively Inhibits Pulmonary Metastasis of CXCR4-Expressing Melanoma Cells Due to Enhanced Serum Stability
Data from A Locked, Dimeric CXCL12 Variant Effectively Inhibits Pulmonary Metastasis of CXCR4-Expressing Melanoma Cells Due to Enhanced Serum Stability Open
The CXC chemokine receptor-4 (CXCR4) plays a critical role in cancer by positively regulating cancer cell metastasis and survival. We previously showed that high concentrations of the CXCR4 ligand, wild-type CXCL12 (wtCXCL12), could inhibi…
View article: Data from A Locked, Dimeric CXCL12 Variant Effectively Inhibits Pulmonary Metastasis of CXCR4-Expressing Melanoma Cells Due to Enhanced Serum Stability
Data from A Locked, Dimeric CXCL12 Variant Effectively Inhibits Pulmonary Metastasis of CXCR4-Expressing Melanoma Cells Due to Enhanced Serum Stability Open
The CXC chemokine receptor-4 (CXCR4) plays a critical role in cancer by positively regulating cancer cell metastasis and survival. We previously showed that high concentrations of the CXCR4 ligand, wild-type CXCL12 (wtCXCL12), could inhibi…
View article: Supplementary Figure 4 from A Locked, Dimeric CXCL12 Variant Effectively Inhibits Pulmonary Metastasis of CXCR4-Expressing Melanoma Cells Due to Enhanced Serum Stability
Supplementary Figure 4 from A Locked, Dimeric CXCL12 Variant Effectively Inhibits Pulmonary Metastasis of CXCR4-Expressing Melanoma Cells Due to Enhanced Serum Stability Open
PDF file, 77K, Full length blots of Figure 3B and Figure 5A.
View article: Figure S4 from Leukocyte Heterogeneity in Pancreatic Ductal Adenocarcinoma: Phenotypic and Spatial Features Associated with Clinical Outcome
Figure S4 from Leukocyte Heterogeneity in Pancreatic Ductal Adenocarcinoma: Phenotypic and Spatial Features Associated with Clinical Outcome Open
Figure S4 is related to Figure 4. It shows leukocyte composition based on tumor grade, molecular status, and histopathologic region.
View article: Figure S1 from Leukocyte Heterogeneity in Pancreatic Ductal Adenocarcinoma: Phenotypic and Spatial Features Associated with Clinical Outcome
Figure S1 from Leukocyte Heterogeneity in Pancreatic Ductal Adenocarcinoma: Phenotypic and Spatial Features Associated with Clinical Outcome Open
Figure S1 is related to Figure 1 and shows image cytometry gating strategies used in multiplex IHC analysis
View article: Figure S6 from Leukocyte Heterogeneity in Pancreatic Ductal Adenocarcinoma: Phenotypic and Spatial Features Associated with Clinical Outcome
Figure S6 from Leukocyte Heterogeneity in Pancreatic Ductal Adenocarcinoma: Phenotypic and Spatial Features Associated with Clinical Outcome Open
Figure S6 is related to Figure 6. It shows leukocyte densities and phenotypes in treatment-naive short-term versus long-term survivors
View article: Figure S3 from Leukocyte Heterogeneity in Pancreatic Ductal Adenocarcinoma: Phenotypic and Spatial Features Associated with Clinical Outcome
Figure S3 from Leukocyte Heterogeneity in Pancreatic Ductal Adenocarcinoma: Phenotypic and Spatial Features Associated with Clinical Outcome Open
Figure S3 is related to Figure 3 and shows comparisons of leukocyte densities between treatment-naive PDACS from Cohort 1 and Cohort 2, shows leukocyte subpopulations whose density most strongly correlates to total leukocyte density within…
View article: Figure S3 from Leukocyte Heterogeneity in Pancreatic Ductal Adenocarcinoma: Phenotypic and Spatial Features Associated with Clinical Outcome
Figure S3 from Leukocyte Heterogeneity in Pancreatic Ductal Adenocarcinoma: Phenotypic and Spatial Features Associated with Clinical Outcome Open
Figure S3 is related to Figure 3 and shows comparisons of leukocyte densities between treatment-naive PDACS from Cohort 1 and Cohort 2, shows leukocyte subpopulations whose density most strongly correlates to total leukocyte density within…
View article: Supplementary Figure 1 from A Locked, Dimeric CXCL12 Variant Effectively Inhibits Pulmonary Metastasis of CXCR4-Expressing Melanoma Cells Due to Enhanced Serum Stability
Supplementary Figure 1 from A Locked, Dimeric CXCL12 Variant Effectively Inhibits Pulmonary Metastasis of CXCR4-Expressing Melanoma Cells Due to Enhanced Serum Stability Open
PDF file, 28K, CXCL122 inhibited CXCR4-positive B16-F1 lung metastasis but did not affect CXCR4 B16-F1lung metastasis.