Samuel J. Beck
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View article: Crowdsourced Drug Discovery Approach Identifies BET Inhibitors As Novel Geroprotectors Promoting Healthy Aging
Crowdsourced Drug Discovery Approach Identifies BET Inhibitors As Novel Geroprotectors Promoting Healthy Aging Open
The significant growth of the elderly population, driven by advances in biomedical science and public health, poses a critical socio-economic challenge. Identification and targeting of reliable biomarkers are essential for developing effec…
View article: Inhibition of the Caveolin-1 pathway promotes apoptosis and overcomes pan-tyrosine kinase inhibitor resistance in hepatocellular carcinoma
Inhibition of the Caveolin-1 pathway promotes apoptosis and overcomes pan-tyrosine kinase inhibitor resistance in hepatocellular carcinoma Open
Resistance to multi-tyrosine kinase inhibitors (TKI) is a major clinical concern in advanced hepatocellular carcinoma (HCC). Herein, we aimed to uncover the mechanisms underlying pan-TKI resistance and to identify potential therapeutic tar…
View article: A high-quality genomic catalog of the human oral microbiome broadens its phylogeny and clinical insights
A high-quality genomic catalog of the human oral microbiome broadens its phylogeny and clinical insights Open
Understanding the taxonomic and functional diversity of the human oral microbiome requires comprehensive genomic catalogs. We present the human reference oral microbiome (HROM), with 72,641 high-quality genomes from 3,426 species, includin…
View article: Autologous minced cartilage implantation in osteochondral lesions of the talus—does fibrin make the difference?
Autologous minced cartilage implantation in osteochondral lesions of the talus—does fibrin make the difference? Open
Introduction Implantation of minced cartilage is a one-step-procedure that leads to satisfactory results in osteochondral defects. Material and methods A retrospective review was performed on a consecutive cohort of patients that received …
View article: The CoREST complex inhibitor, corin, leads to decreased tumor growth, increased cellular differentiation and extended lifespan in atypical teratoid rhabdoid tumor xenograft models
The CoREST complex inhibitor, corin, leads to decreased tumor growth, increased cellular differentiation and extended lifespan in atypical teratoid rhabdoid tumor xenograft models Open
Background Atypical teratoid rhabdoid tumor (ATRT) is the most common malignant brain tumor in infants, and more than 60% of children with ATRT die from their tumor. ATRT is associated with mutational inactivation/deletion of SMARCB1 , a m…
View article: Perspectives on Microbiome Therapeutics in Infectious Diseases: A Comprehensive Approach Beyond Immunology and Microbiology
Perspectives on Microbiome Therapeutics in Infectious Diseases: A Comprehensive Approach Beyond Immunology and Microbiology Open
Although global life expectancy has increased over the past 20 years due to advancements in managing infectious diseases, one-fifth of people still die from infections. In response to this ongoing threat, significant efforts are underway t…
View article: Disagreement on foundational principles of biological aging
Disagreement on foundational principles of biological aging Open
To gain insight into how researchers of aging perceive the process they study, we conducted a survey among experts in the field. While highlighting some common features of aging, the survey exposed broad disagreement on the foundational is…
View article: “Single‐cell multimodal chromatin profiles revealing epigenetic regulations of cells in hepatocellular carcinoma”
“Single‐cell multimodal chromatin profiles revealing epigenetic regulations of cells in hepatocellular carcinoma” Open
Hepatocellular carcinoma (HCC), with its increasing prevalence globally, is emerging as a major health challenge. Hepatocellular carcinoma cells exhibit both significant homogeneity and heterogeneity, governed by complex epigenomic regulat…
View article: Histopathological features of subcutaneous and cutaneous mast cell tumors in dogs
Histopathological features of subcutaneous and cutaneous mast cell tumors in dogs Open
Background Mast cell tumors (MCTs) are the most common malignant skin neoplasms in dogs. In the past, the distinction between cutaneous MCTs (cMCTs), originating from the dermis, and subcutaneous MCTs (scMCTs), originating from the subcuta…
View article: Elevated α-1,2-mannosidase MAN1C1 in glioma stem cells and its implications for immunological changes and prognosis in glioma patients
Elevated α-1,2-mannosidase MAN1C1 in glioma stem cells and its implications for immunological changes and prognosis in glioma patients Open
Glioblastoma multiforme (GBM) is the most aggressive type of primary brain tumor, and the presence of glioma stem cells (GSCs) has been linked to its resistance to treatments and recurrence. Additionally, aberrant glycosylation has been im…
View article: Two-point Equidistant Projection and Degree-of-interest Filtering for Smooth Exploration of Geo-referenced Networks
Two-point Equidistant Projection and Degree-of-interest Filtering for Smooth Exploration of Geo-referenced Networks Open
The visualization and interactive exploration of geo-referenced networks poses challenges if the network's nodes are not evenly distributed. Our approach proposes new ways of realizing animated transitions for exploring such networks from …
View article: Signalment of dogs and histopathological features of subcutaneous and cutaneous mast cell tumors
Signalment of dogs and histopathological features of subcutaneous and cutaneous mast cell tumors Open
Background Mast cell tumors (MCTs) are the most common malignant skin neoplasms in dogs. In the past, the distinction between cutaneous MCTs (cMCTs), originating from the dermis, and subcutaneous MCTs (scMCTs), originating from the subcuta…
View article: The impact of <i>MEIS1</i> TALE homeodomain transcription factor knockdown on glioma stem cell growth
The impact of <i>MEIS1</i> TALE homeodomain transcription factor knockdown on glioma stem cell growth Open
Myeloid ecotropic virus insertion site 1 (MEIS1) is a HOX co-factor necessary for organ development and normal hematopoiesis. Recently, MEIS1 has been linked to the development and progression of various cancers. However, its role in gliom…
View article: Diversity in EWAS: current state, challenges, and solutions
Diversity in EWAS: current state, challenges, and solutions Open
Here, we report a lack of diversity in epigenome-wide association studies (EWAS) and DNA methylation (DNAm) data, discuss current challenges, and propose solutions for EWAS and DNAm research in diverse populations. The strategies we propos…
View article: Epigenome-wide association study of kidney function identifies trans-ethnic and ethnic-specific loci
Epigenome-wide association study of kidney function identifies trans-ethnic and ethnic-specific loci Open
Background: DNA methylation (DNAm) is associated with gene regulation and estimated glomerular filtration rate (eGFR), a measure of kidney function. Decreased eGFR is more common among US Hispanics and African Americans. The causes for thi…
View article: The CoREST repressor complex mediates phenotype switching and therapy resistance in melanoma
The CoREST repressor complex mediates phenotype switching and therapy resistance in melanoma Open
Virtually all patients with BRAF-mutant melanoma develop resistance to MAPK inhibitors largely through nonmutational events. Although the epigenetic landscape is shown to be altered in therapy-resistant melanomas and other cancers, a speci…
View article: Suspected Primary Intracranial Melanoma with Widespread Distant Metastases in a Cat
Suspected Primary Intracranial Melanoma with Widespread Distant Metastases in a Cat Open
An 8-year-old female Domestic Shorthair presented with signs of intracranial disease. Magnetic resonance imaging (MRI) of the head showed an extra-axial space-occupying mass within the cranial vault with a similar intensity lesion within t…
View article: Fecal microbiota transplanted from old mice promotes more colonic inflammation, proliferation, and tumor formation in azoxymethane-treated A/J mice than microbiota originating from young mice
Fecal microbiota transplanted from old mice promotes more colonic inflammation, proliferation, and tumor formation in azoxymethane-treated A/J mice than microbiota originating from young mice Open
Aging is a strong risk factor for colorectal cancer (CRC). It is well established that gut microbial dysbiosis can play a role in the etiology of CRC. Although the composition of the gut microbial community changes with age and is reported…
View article: Characterization of canine intestinal microRNA expression in inflammatory bowel disease and T-cell lymphoma
Characterization of canine intestinal microRNA expression in inflammatory bowel disease and T-cell lymphoma Open
Differentiating between canine inflammatory bowel disease (IBD) and intestinal T-cell lymphoma by histopathological examination of endoscopically-derived intestinal biopsies can be challenging and involves an invasive procedure requiring s…
View article: Supplementary Methods, Figure Legends 1-12 from ID4 Imparts Chemoresistance and Cancer Stemness to Glioma Cells by Derepressing miR-9*–Mediated Suppression of SOX2
Supplementary Methods, Figure Legends 1-12 from ID4 Imparts Chemoresistance and Cancer Stemness to Glioma Cells by Derepressing miR-9*–Mediated Suppression of SOX2 Open
Supplementary Methods, Figure Legends 1-12 from ID4 Imparts Chemoresistance and Cancer Stemness to Glioma Cells by Derepressing miR-9*–Mediated Suppression of SOX2
View article: Data from Frizzled 4 Regulates Stemness and Invasiveness of Migrating Glioma Cells Established by Serial Intracranial Transplantation
Data from Frizzled 4 Regulates Stemness and Invasiveness of Migrating Glioma Cells Established by Serial Intracranial Transplantation Open
One of the most detrimental hallmarks of glioblastoma multiforme (GBM) is cellular invasiveness, which is considered a potential cause of tumor recurrence. Infiltrated GBM cells are difficult to completely eradicate surgically and with loc…
View article: Supplementary Methods, Figures 1-7, Table 1 from EGFR-AKT-Smad Signaling Promotes Formation of Glioma Stem-like Cells and Tumor Angiogenesis by ID3-Driven Cytokine Induction
Supplementary Methods, Figures 1-7, Table 1 from EGFR-AKT-Smad Signaling Promotes Formation of Glioma Stem-like Cells and Tumor Angiogenesis by ID3-Driven Cytokine Induction Open
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View article: Supplementary Methods, Figure Legends 1-12 from ID4 Imparts Chemoresistance and Cancer Stemness to Glioma Cells by Derepressing miR-9*–Mediated Suppression of SOX2
Supplementary Methods, Figure Legends 1-12 from ID4 Imparts Chemoresistance and Cancer Stemness to Glioma Cells by Derepressing miR-9*–Mediated Suppression of SOX2 Open
Supplementary Methods, Figure Legends 1-12 from ID4 Imparts Chemoresistance and Cancer Stemness to Glioma Cells by Derepressing miR-9*–Mediated Suppression of SOX2
View article: Data from EGFR-AKT-Smad Signaling Promotes Formation of Glioma Stem-like Cells and Tumor Angiogenesis by ID3-Driven Cytokine Induction
Data from EGFR-AKT-Smad Signaling Promotes Formation of Glioma Stem-like Cells and Tumor Angiogenesis by ID3-Driven Cytokine Induction Open
Aberrant activation of receptor tyrosine kinases (RTK) is causally linked to the pathobiological traits of glioblastoma and genesis of glioma stem-like cells (GSC), but the underlying mechanism is still unknown. Here, we show that epiderma…
View article: Data from Frizzled 4 Regulates Stemness and Invasiveness of Migrating Glioma Cells Established by Serial Intracranial Transplantation
Data from Frizzled 4 Regulates Stemness and Invasiveness of Migrating Glioma Cells Established by Serial Intracranial Transplantation Open
One of the most detrimental hallmarks of glioblastoma multiforme (GBM) is cellular invasiveness, which is considered a potential cause of tumor recurrence. Infiltrated GBM cells are difficult to completely eradicate surgically and with loc…
View article: Supplementary Methods, Figures 1-2 from Frizzled 4 Regulates Stemness and Invasiveness of Migrating Glioma Cells Established by Serial Intracranial Transplantation
Supplementary Methods, Figures 1-2 from Frizzled 4 Regulates Stemness and Invasiveness of Migrating Glioma Cells Established by Serial Intracranial Transplantation Open
Supplementary Methods, Figures 1-2 from Frizzled 4 Regulates Stemness and Invasiveness of Migrating Glioma Cells Established by Serial Intracranial Transplantation
View article: Data from ID4 Imparts Chemoresistance and Cancer Stemness to Glioma Cells by Derepressing miR-9*–Mediated Suppression of SOX2
Data from ID4 Imparts Chemoresistance and Cancer Stemness to Glioma Cells by Derepressing miR-9*–Mediated Suppression of SOX2 Open
Glioma stem cells (GSC) possess tumor-initiating potential and are relatively resistant to conventional chemotherapy and irradiation. Thus, they are considered to be major drivers for glioma initiation, progression, and recurrence. However…
View article: Supplementary Methods, Figures 1-2 from Frizzled 4 Regulates Stemness and Invasiveness of Migrating Glioma Cells Established by Serial Intracranial Transplantation
Supplementary Methods, Figures 1-2 from Frizzled 4 Regulates Stemness and Invasiveness of Migrating Glioma Cells Established by Serial Intracranial Transplantation Open
Supplementary Methods, Figures 1-2 from Frizzled 4 Regulates Stemness and Invasiveness of Migrating Glioma Cells Established by Serial Intracranial Transplantation
View article: Supplementary Tables 1-3, Figures 1-12 from ID4 Imparts Chemoresistance and Cancer Stemness to Glioma Cells by Derepressing miR-9*–Mediated Suppression of SOX2
Supplementary Tables 1-3, Figures 1-12 from ID4 Imparts Chemoresistance and Cancer Stemness to Glioma Cells by Derepressing miR-9*–Mediated Suppression of SOX2 Open
Supplementary Tables 1-3, Figures 1-12 from ID4 Imparts Chemoresistance and Cancer Stemness to Glioma Cells by Derepressing miR-9*–Mediated Suppression of SOX2
View article: Supplementary Tables 1-3, Figures 1-12 from ID4 Imparts Chemoresistance and Cancer Stemness to Glioma Cells by Derepressing miR-9*–Mediated Suppression of SOX2
Supplementary Tables 1-3, Figures 1-12 from ID4 Imparts Chemoresistance and Cancer Stemness to Glioma Cells by Derepressing miR-9*–Mediated Suppression of SOX2 Open
Supplementary Tables 1-3, Figures 1-12 from ID4 Imparts Chemoresistance and Cancer Stemness to Glioma Cells by Derepressing miR-9*–Mediated Suppression of SOX2