Samuel J. Chen
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View article: Cytoplasmic Abundant Heat-Soluble Proteins from Tardigrades Protect Synthetic Cells Under Stress
Cytoplasmic Abundant Heat-Soluble Proteins from Tardigrades Protect Synthetic Cells Under Stress Open
Cytoplasmic abundant heat-soluble (CAHS) proteins, a stress-responsive intrinsically disordered protein from tardigrades, have been discovered to form gel-like networks providing structural support during dehydration, thus enabling anhydro…
View article: Cellular mechanotransduction of human osteoblasts in microgravity
Cellular mechanotransduction of human osteoblasts in microgravity Open
Astronauts experience significant and rapid bone loss as a result of an extended stay in space, making the International Space Station (ISS) the perfect laboratory for studying osteoporosis due to the accelerated nature of bone loss on the…
View article: Matrix confinement modulates 3D spheroid sorting and burst-like collective migration
Matrix confinement modulates 3D spheroid sorting and burst-like collective migration Open
While it is known that cells with differential adhesion tend to segregate and preferentially sort, the physical forces governing sorting and invasion in heterogeneous tumors remain poorly understood. To investigate this, we tune matrix con…
View article: Development of mechanosensitive synthetic cells for biomedical applications
Development of mechanosensitive synthetic cells for biomedical applications Open
The ability of cells to sense and respond to their physical environment plays a fundamental role in a broad spectrum of biological processes. As one of the most essential molecular force sensors and transducers found in cell membranes, mec…
View article: Calcium-triggered DNA-mediated membrane fusion in synthetic cells
Calcium-triggered DNA-mediated membrane fusion in synthetic cells Open
We develop a novel calcium-triggered membrane fusion strategy for synthetic cells by regulating DNA-mediated membrane fusion with membrane-bound polyethylene glycol polymeric chains that are cleavable by the calcium-activated protease calp…
View article: Inhibition of PAR-1 delays aging via activating AMPK in C. elegans
Inhibition of PAR-1 delays aging via activating AMPK in C. elegans Open
The antagonistic pleiotropy theory of aging suggests that genes essential for growth and development are likely to modulate aging later in life. Previous studies in C. elegans demonstrate that inhibition of certain developmentally essentia…