Samuel J. E. Lucas
YOU?
Author Swipe
View article: Strategies to Augment the Cardiovascular System and Acutely Enhance Exercise Performance in Individuals with Spinal Cord Injury: A Systematic Scoping Review
Strategies to Augment the Cardiovascular System and Acutely Enhance Exercise Performance in Individuals with Spinal Cord Injury: A Systematic Scoping Review Open
View article: Heat thermotherapy to improve cardiovascular function and cardiometabolic health: A systematic review and meta‐analysis
Heat thermotherapy to improve cardiovascular function and cardiometabolic health: A systematic review and meta‐analysis Open
Heat thermotherapy (HT) is reported to promote cardiovascular (CV) and cardiometabolic health benefits. This systematic review and meta‐analysis (CRD42020193669) empirically investigated the efficacy of HT in improving CV and cardiometabol…
View article: Dietary flavanols preserve upper‐ and lower‐limb endothelial function during sitting in high‐ and low‐fit young healthy males
Dietary flavanols preserve upper‐ and lower‐limb endothelial function during sitting in high‐ and low‐fit young healthy males Open
Sedentary behaviour is very prevalent in modern societies, with young adults spending approximately 6 h/day sitting. Sitting induces declines in endothelial function, increasing the risk of cardiovascular diseases. Nutrition during sitting…
View article: Explaining tip-of-the-tongue experiences in older adults: The role of brain-based and cardiorespiratory fitness factors
Explaining tip-of-the-tongue experiences in older adults: The role of brain-based and cardiorespiratory fitness factors Open
Cognitive decline associated with healthy ageing is multifactorial: brain-based and lifestyle factors uniquely and jointly contribute to distinct neurocognitive trajectories of ageing. To evaluate existing models of neurocognitive ageing s…
View article: The Impact of Cocoa Flavanols in Modulating Resting Cerebral Blood Flow During Prolonged Sitting in Healthy Young and Older Adults
The Impact of Cocoa Flavanols in Modulating Resting Cerebral Blood Flow During Prolonged Sitting in Healthy Young and Older Adults Open
Background: Sitting is highly prevalent among young and older adults and can transiently reduce cerebral blood flow. Dietary flavanols confer benefits to the peripheral vasculature and may be effective at counteracting the impact of sittin…
View article: Mapping the evidence on the impact of heat stress on exercise and work performance in females: a scoping review
Mapping the evidence on the impact of heat stress on exercise and work performance in females: a scoping review Open
Increasing numbers of females are performing in increasingly hot environments. This scoping review aimed to 1) collate evidence on the effects of environmental heat stress on aerobic exercise performance and work productivity in females sp…
View article: Analytical and clinical validation of PATHWAY HER2 (4B5) assay for assessment of HER2-low/HER2-ultralow status and eligibility for trastuzumab deruxtecan in DESTINY-Breast06
Analytical and clinical validation of PATHWAY HER2 (4B5) assay for assessment of HER2-low/HER2-ultralow status and eligibility for trastuzumab deruxtecan in DESTINY-Breast06 Open
For patients with HER2 IHC 0 mBC, rescoring and/or retesting with the Roche HER2 4B5 assay is encouraged to determine eligibility for T-DXd.
View article: Brain derived neurotrophic factor and secreted amyloid precursor protein‐α response to moderate and high intensity exercise
Brain derived neurotrophic factor and secreted amyloid precursor protein‐α response to moderate and high intensity exercise Open
Brain‐derived neurotrophic factor (BDNF) and secreted amyloid precursor protein‐alpha (sAPPα) promote neuronal growth but are lower in people with Alzheimer's Disease (AD). BDNF increases after exercise, but the response may vary with exer…
View article: Intra-apheresis Cycling to Improve the Clinical Efficacy of Peripheral Blood Stem Cell Donations
Intra-apheresis Cycling to Improve the Clinical Efficacy of Peripheral Blood Stem Cell Donations Open
Peripheral blood stem cell (PBSC) donation is the primary procedure used to collect haemopoietic stem cells (HSCs) for transplantation in individuals with haematological malignancies. More than 90,000 HSC transplants take place globally ea…
View article: Can 4 weeks of real-world active breaks improve glycaemic management in sedentary adults with type 1 diabetes? The EXTOD-Active randomised control trial protocol
Can 4 weeks of real-world active breaks improve glycaemic management in sedentary adults with type 1 diabetes? The EXTOD-Active randomised control trial protocol Open
Sedentary behaviour is associated with an increased risk of cardiovascular disease and all-cause mortality in individuals with type 1 diabetes (T1D). Recent laboratory-based research suggests that breaking up prolonged sedentary periods im…
View article: ‘Time is of the essence’: upper-body aerobic exercise to improve cardiovascular health during inpatient rehabilitation within the first year following spinal cord injury – protocol for a randomised clinical trial
‘Time is of the essence’: upper-body aerobic exercise to improve cardiovascular health during inpatient rehabilitation within the first year following spinal cord injury – protocol for a randomised clinical trial Open
Introduction Individuals with spinal cord injury (SCI) face heightened cardiovascular disease (CVD) risks. While general exercise guidelines are promoted for SCI individuals, when and how to incorporate exercise during the subacute phase p…
View article: Examining the effect of intermittent cycling throughout a 3-h period on peripheral blood concentrations of haemopoietic stem and progenitor cells and cytolytic natural killer cells
Examining the effect of intermittent cycling throughout a 3-h period on peripheral blood concentrations of haemopoietic stem and progenitor cells and cytolytic natural killer cells Open
View article: Assessing the Utility of Predicted Brain Age for Explaining Variability in Language Abilities in Healthy Older Adults
Assessing the Utility of Predicted Brain Age for Explaining Variability in Language Abilities in Healthy Older Adults Open
We investigated whether the difference between chronological and modeled brain age explains individual differences in language performance among healthy older adults. Age-related decline in language abilities is widely documented, with con…
View article: Short- and long-term effects of transcutaneous spinal cord stimulation on autonomic cardiovascular control and arm-crank exercise capacity in individuals with a spinal cord injury (STIMEX-SCI): study protocol
Short- and long-term effects of transcutaneous spinal cord stimulation on autonomic cardiovascular control and arm-crank exercise capacity in individuals with a spinal cord injury (STIMEX-SCI): study protocol Open
Introduction Individuals with higher neurological levels of spinal cord injury (SCI) at or above the sixth thoracic segment (≥T6), exhibit impaired resting cardiovascular control and responses during upper-body exercise. Over time, impaire…
View article: Current and prospective roles of magnetic resonance imaging in mild traumatic brain injury
Current and prospective roles of magnetic resonance imaging in mild traumatic brain injury Open
There is unmet clinical need for biomarkers to predict recovery or the development of long-term sequelae of mild traumatic brain injury, a highly prevalent condition causing a constellation of disabling symptoms. A substantial proportion o…
View article: Effects of increasing fitness through exercise training on language comprehension in monolingual and bilingual older adults: a randomized controlled trial
Effects of increasing fitness through exercise training on language comprehension in monolingual and bilingual older adults: a randomized controlled trial Open
Exercise training has been proposed to counteract age-related cognitive decline through improvements in cardiorespiratory fitness (CRF hypothesis). Research has focused on cognitive domains like attention and processing speed, and one cros…
View article: Cerebral blood flow and arterial transit time responses to exercise training in older adults
Cerebral blood flow and arterial transit time responses to exercise training in older adults Open
Brain vascular health worsens with age, as is made evident by resting grey matter cerebral blood flow (CBFGM) reductions and lengthening arterial transit time (ATTGM). Exercise training can improve aspects of brain he…
View article: Pulse oximetry for the prediction of acute mountain sickness: A systematic review
Pulse oximetry for the prediction of acute mountain sickness: A systematic review Open
Acute mountain sickness (AMS) causes serious illness for many individuals ascending to high altitude (HA), although preventable with appropriate acclimatisation. AMS is a clinical diagnosis, with symptom severity evaluated using the Lake L…
View article: Determinants of cerebral blood flow and arterial transit time in healthy older adults
Determinants of cerebral blood flow and arterial transit time in healthy older adults Open
Cerebral blood flow (CBF) and arterial transit time (ATT), markers of brain vascular health, worsen with age. The primary aim of this cross-sectional study was to identify modifiable determinants of CBF and ATT in healthy older adults (…
View article: Nocturnal pulse oximetry for the detection and prediction of acute mountain sickness: An observational study
Nocturnal pulse oximetry for the detection and prediction of acute mountain sickness: An observational study Open
Acute mountain sickness (AMS) is a well‐studied illness defined by clinical features (e.g., headache and nausea), as assessed by the Lake Louise score (LLS). Although obvious in its severe form, early stages of AMS are poorly defined and e…
View article: Neurovascular coupling methods in healthy individuals using transcranial doppler ultrasonography: A systematic review and consensus agreement
Neurovascular coupling methods in healthy individuals using transcranial doppler ultrasonography: A systematic review and consensus agreement Open
Neurovascular coupling (NVC) is the perturbation of cerebral blood flow (CBF) to meet varying metabolic demands induced by various levels of neural activity. NVC may be assessed by Transcranial Doppler ultrasonography (TCD), using task act…
View article: Brief cycling intervals incrementally increase the number of hematopoietic stem and progenitor cells in human peripheral blood
Brief cycling intervals incrementally increase the number of hematopoietic stem and progenitor cells in human peripheral blood Open
Introduction Peripheral blood stem cell (PBSC) donation is the primary procedure used to collect hematopoietic stem and progenitor cells (HSPCs) for hematopoietic stem cell transplantation. Single bouts of exercise transiently enrich perip…
View article: Evaluating the Phenotypic Patterns of Post-Traumatic Headache: A Systematic Review of Military Personnel
Evaluating the Phenotypic Patterns of Post-Traumatic Headache: A Systematic Review of Military Personnel Open
Introduction Mild traumatic brain injury (TBI) affects a significant number of military personnel, primarily because of physical impact, vehicle incidents, and blast exposure. Post-traumatic headache (PTH) is the most common symptom report…
View article: <scp>HIIT</scp> at Home: Enhancing Cardiorespiratory Fitness in Older Adults—A Randomized Controlled Trial
<span>HIIT</span> at Home: Enhancing Cardiorespiratory Fitness in Older Adults—A Randomized Controlled Trial Open
Background This study aimed to investigate the effectiveness of a 6‐month home‐based high‐intensity interval training (HIIT) intervention to improve peak oxygen consumption (V̇O 2 peak) and lactate threshold (LT) in older adults. Methods Tw…
View article: Variability of flow-mediated dilation across lower and upper limb conduit arteries
Variability of flow-mediated dilation across lower and upper limb conduit arteries Open
View article: Effects of exercise training on language comprehension_final
Effects of exercise training on language comprehension_final Open
Exercise training has been proposed to counteract age-related cognitive decline through improvements in cardiorespiratory fitness (CRF hypothesis). Research has focused on cognitive domains such as attention and processing speed, and one c…
View article: Cerebral blood flow and arterial transit time responses to home-based exercise training in healthy older adults
Cerebral blood flow and arterial transit time responses to home-based exercise training in healthy older adults Open
Brain vascular health worsens with age, evident by grey matter cerebral blood flow (CBFGM) reductions and lengthening arterial transit time (ATTGM). Exercise training can improve aspects of brain health in older adults, yet its effects on …
View article: Isometric Exercise Training and Arterial Hypertension: An Updated Review
Isometric Exercise Training and Arterial Hypertension: An Updated Review Open
Hypertension is recognised as a leading attributable risk factor for cardiovascular disease and premature mortality. Global initiatives towards the prevention and treatment of arterial hypertension are centred around non-pharmacological li…
View article: Cerebrovascular Reactivity Following Spinal Cord Injury
Cerebrovascular Reactivity Following Spinal Cord Injury Open
Background: Spinal cord injuries (SCI) often result in cardiovascular issues, increasing the risk of stroke and cognitive deficits. Objectives: This study assessed cerebrovascular reactivity (CVR) using functional magnetic resonance imagin…
View article: The intensity paradox: A systematic review and meta‐analysis of its impact on the cardiorespiratory fitness of older adults
The intensity paradox: A systematic review and meta‐analysis of its impact on the cardiorespiratory fitness of older adults Open
Aim The present systematic review and meta‐analysis aimed to compare the effect of moderate‐ versus high‐intensity aerobic exercise on cardiorespiratory fitness (CRF) in older adults, taking into account the volume of exercise completed. M…