Explanipedia

The pattern of arm lymphatic drainage and subclinical lymphedema progression after axillary lymph node dissection: a prospective cohort study Open

Bayu Brahma, Takumi Yamamoto, Sonar Soni Panigoro, Samuel J Haryono, Prasandhya Astagiri Yusuf , et al. · 2025

Background: Breast cancer treatment-related lymphedema (BCRL) is a chronic progressive morbidity for which a definitive cure has not yet been achieved. Since axillary lymph node dissection (ALND) is the main risk factor, we have studied th…

Determinants of Survival in Triple-Negative Breast Cancer: A Clinicopathological Study from Indonesian Cancer Centre Open

Samuel J Haryono, Yuniar Harris Prayitno, Noorwati Sutandyo · 2025

Background Triple-negative breast cancer (TNBC) poses distinct clinical challenges due to its aggressive behaviour and lack of targeted therapies. In Indonesia, socioeconomic disparities and late-stage diagnosis exacerbate poor outcomes. O…

A combined risk model shows viability for personalized breast cancer risk assessment in the Indonesian population: A case/control study Open

Bijak Rabbani, Sabrina Gabriel Tanu, Kevin Nathanael Ramanto, Jessica Audrienna, Eric Aria Fernandez , et al. · 2025

Breast cancer remains a significant concern worldwide, with a rising incidence in Indonesia. This study aims to evaluate the applicability of risk-based screening approaches in the Indonesian demographic through a case-control study involv…

CYP2D6 Genotyping for Optimization of Tamoxifen Therapy in Indonesian Women with ER+ Breast Cancer Open

Baitha Palanggatan Maggadani, Kathleen Irena Junusmin, Fatma Aldila, Jessica Audrienna, Bijak Rabbani , et al. · 2025

Background: Certain CYP2D6 genotypes are linked to a lower efficacy of tamoxifen therapy. This study aimed to observe CYP2D6 polymorphisms and examine the impact of CYP2D6 genotyping among tamoxifen-treated breast cancer patients in Indone…

Complete excision and management of large hyaline-vascular pelvic Castleman's disease with coexisting cholecystolithiasis: A rare case report Open

Wifanto Saditya Jeo, Samuel J Haryono, Fajar Lamhot Gultom, Dismas Adiasa Chaspuri, Rachmat Christian Nikijuluw , et al. · 2025

Indocyanine Green Lymphography Screening of Breast Cancer-Related Lymphedema: A Two-Year Prospective Cohort Study after Axillary Lymph Node Dissection Open

Bayu Brahma, Takumi Yamamoto, Sonar Soni Panigoro, Samuel J Haryono, Rizky Ifandriani Putri , et al. · 2024

Background/Objectives: Breast cancer-related lymphedema (BCRL) is one of the major morbidity in breast cancer. Since lymphedema treatment is difficult, especially once it progresses, screening and early detection should be prioritized to p…

What do women want to see in a personalized breast cancer risk report? A qualitative study of Asian women of two countries Open

Fatma Aldila, Fiona Ng Fj, Jessica Audrienna, Lynn Lim Sj, Shannon Tang , et al. · 2024

Prognostic Values of CD8+, PARP, and EGFR on Overall Survival in Patients with Triple-Negative Breast Cancer Open

Rizky Ifandriani Putri, Samuel J Haryono, Bayu Brahma, Yuniar Harris Prayitno, Noorwati Sutandyo · 2024

Patients with low CD8+, positive PARP, and positive EGFR expressions seem to be associated with poorer overall survival in TNBC. After approximately one year of follow-up, higher survival was observed in patients with high CD8+, negative P…

Supermicrosurgery lymphaticovenous and lymphaticolymphatic anastomosis: Technical detail and short-term follow-up for immediate lymphatic reconstruction in breast cancer treatment-related lymphedema prevention Open

Bayu Brahma, Takumi Yamamoto, Sonar Soni Panigoro, Samuel J Haryono, Prasandhya Astagiri Yusuf , et al. · 2024

Along with the emerging immediate lymphatic reconstruction, LBS is a feasible supermicrosurgery technique that may have a potential role in BCRL prevention. A randomized controlled study would confirm the effectiveness of the technique.

A combined risk model shows viability for personalized breast cancer risk assessment in the Indonesian population Open

Bijak Rabbani, Sabrina Gabriel Tanu, Kevin Nathanael Ramanto, Jessica Audrienna, Fatma Aldila , et al. · 2023

Breast cancer remains a significant concern worldwide, with a rising incidence in Indonesia. This study aims to evaluate the applicability of risk-based screening approaches in the Indonesian demographic through a case-control study involv…

Chemical Analysis of Ethanolic Extract of Ripe Fruit, N-Hexane Fraction of Half-Ripe Fruit, and Water Fraction of Half-Ripe Fruit of Sesoot (Garcinia Picrorrhiza Miq.) with Liquid Chromatography-Mass Spectrometry (Lc-Ms) Open

Sri Utami, Erni Hernawati Purwaningsih, Samuel J Haryono, Chaidir Chaidir · 2023

Garcinia is a plant belonging to the family of Guttiferae or Cluciaceae and has more than 180 famous species. Most of Garcinia species contains many prenelated xanthones, biflavonoids, and benzophenones. Using Liquid Chromatography - Mass …

Curcumin as an anti-proliferative agent in breast cancer through RassF1a, Bax, and caspase-3 protein Open

Nunung Ainur Rahmah, H. Harliansyah, Franciscus D. Suyatna, Mpu Kanoko, Primariadewi Rustamadji , et al. · 2022

Background . Curcumin is a polyphenol that has pharmacological activity that can inhibit tumor cell growth and induce apoptosis through various mechanisms. However, the specifc mechanism of curcumin cytotoxicity remains controversial becau…

ESR1 PvuII polymorphism: from risk factor to prognostic and predictive factor of the success of primary systemic therapy in advanced breast cancer Open

Ramadhan Karsono, Samuel J Haryono, Bambang Karsono, Wirsma Arif Harahap, Yulia Pratiwi , et al. · 2021

Curcumin as an Anti-Proliferative Agent in Breast Cancer through RASSF1A, Bax, and Caspase-3 Protein Open

Nunung Ainur Rahma, Harliansyah, Fransiscus D. Suyatna, Mpu Kanoko, Primariadewi Rustamadji , et al. · 2021

Introduction: Curcumin is a polyphenol that has pharmacological activity that can inhibit tumor cell growth and induce apoptosis through various mechanisms. However, the specific mechanism of curcumin cytotoxicity remains controversial bec…

Survey data of multidrug-resistant tuberculosis, Tuberculosis patients characteristics and stress resilience during COVID-19 pandemic in West Sumatera Province, Indonesia Open

Ricvan Dana Nindrea, Nissa Prima Sari, Wirsma Arif Harahap, Samuel J Haryono, Hari Kusnanto , et al. · 2020

This set of data presents a survey data describing multidrug-resistant tuberculosis, tuberculosis patients characteristics and stress resilience during COVID-19 pandemic in West Sumatera Province, Indonesia. The data were gathered from mul…

Survey data of COVID-19 awareness, knowledge, preparedness and related behaviors among breast cancer patients in Indonesia Open

Ricvan Dana Nindrea, Nissa Prima Sari, Wirsma Arif Harahap, Samuel J Haryono, Hari Kusnanto , et al. · 2020

The Role of Curcumin on Apoptosis through The RASSF1A and Bax Pathways in Breast Cancer Open

Nunung Ainur Rahmah, Harliansyah Harliansyah, Fransiscus D. Suyatna, Mpu Kanoko, Primariadewi Rustamadji , et al. · 2020

Curcumin has been reported with an in vitro the cytotoxic effect on several human cancer cells. However, reports on the mode of action and detail mechanism of curcumin in breast cancer disease are limited. Hence, curcumin’s effect on the h…

ALDH1 Cancer Stem Cell Marker as a Prognostic Factor in Triple-Negative Breast Cancer Open

Sonar Soni Panigoro, Dian Kurnia, Ahmad Kurnia, Samuel J Haryono, Zafiral Azdi Albar · 2020

Breast cancer is the most common cancer with an increasing incidence in Asia. About 20% of all breast cancers are triple-negative breast cancers (TNBCs). BCSC is a subset of tumor cells that has stem cell-like characteristics, such as a hi…

Development of Breast Cancer Risk Prediction Model for Women in Indonesia: A Case-Control Study Open

Ricvan Dana Nindrea, Hari Kusnanto, Samuel J Haryono, Wirsma Arif Harahap, Iwan Dwiprahasto , et al. · 2020

Background: In 2018, estimated that 11.6% or 2,088,849 new breast cancer cases and 6.6% or 626,679 cases are predicted to end with mortality due to this disease. One of the causes of the high mortality rate due to breast cancer in Indonesi…

The Potential of Plasminogen Activator Inhibitor-1 as Prognostic Factor of Advanced Breast Cancer Open

Erwin Danil Yulian, Umar Suratinojo, Diani Kartini, Samuel J Haryono, Kevin Varian Marcevianto , et al. · 2020

Background: Advanced breast cancer causes problems in morbidity, mortality, quality of life, and low survival rate. Hence, a biomarker to predict the progression of cancer is needed. Plasminogen activator inhibitor-1 (PAI-1) has been known…

Treatment Pattern and Safety Results of Docetaxel-(Taxotere®)-Based Chemotherapy in Early Breast Cancer Patients in Indonesia: Part of Asia-Pacific Breast Initiative II Open

Samuel J Haryono, Noorwati Sutandyo, Ramadhan Karsono, Bambang Karsono, Denni Joko Purwanto , et al. · 2019

Background: Breast cancer is the most diagnosed cancer among Indonesian women. Adjuvant chemotherapy plays a crucial role in the management of early breast cancer patients, with docetaxel-based regimens as a cornerstone therapy. The Asia-P…

Preoperative Neoadjuvant Hormonal Therapy and Neoadjuvant Chemotherapy for Stage 3B and 4 Breast Cancer Patients in Dharmais Hospital-National Cancer Center, Indonesia: A Cohort Study Open

Ramadhan Karsono, Denni Joko Purwanto, Samuel J Haryono, Bambang Karsono, Lenny Sari , et al. · 2019

Background: There are no data of efficacy comparison between primary systemic therapy in stage 3B and 4 breast cancer patients in Indonesia. This study compared long term outcomes of breast cancer patients treated with neoadjuvant hormonal…

Neck Dissection in Patients with Oral Squamous Cell Carcinoma in Dharmais Hospital, Jakarta Open

Denni Joko Purwanto, Jauhari Oka Reuwpassa, Asri C. Adisasmita, Marwan Ramli, Ratna Djuwita , et al. · 2018

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Outcomes of Trastuzumab Therapy for 6 and 12 Months in Indonesian National Health Insurance System Clients with Operable HER2-Positive Breast Cancer Open

Wirsma Arif Harahap, Ramadhan, Daan Khambri, Samuel J Haryono, Ricvan Dana Nindrea · 2017

Objective: The aim of this study is to determine the outcome of trastuzumab therapy for 6 or 12 months in patients with HER2 positive operable breast cancer who followed the national health insurance system in Indonesia. Methods: Data were…

The predictive value of methylene blue dye as a single technique in breast cancer sentinel node biopsy: a study from Dharmais Cancer Hospital Open

Bayu Brahma, Rizky Ifandriani Putri, Ramadhan Karsono, Bob Andinata, Walta Gautama , et al. · 2017

BRCA1 and BRCA2: lack of certainty and its clinical implications Open

Samuel J Haryono · 2016

\n\nIn this time of amounting cancer incidence and mortality, genetic testing may be greatly valuable in deciding on appropriate clinical management. It is unfortunate that the test is not a practical interrogative problem. When positive, …

68PD BRCA1/2 mutation analysis in Indonesian hereditary breast Open

Samuel J Haryono, S. Utami · 2016

One step nucleic acid amplification (OSNA) study in Indonesia Open

Samuel J Haryono, Lenny Sari, Sony Sugiharto, I Gusti Bagus Datasena, Raymond Mulyarahardja , et al. · 2016

\nSentinel lymph node (SLN) is defined as the first of a few selected lymphatic nodes, into which lymphatic fluid from a primary tumor drains. Streamlined processing of sentinel lymph nodes (SLN) for detection of lymph node metastasis invo…

68PD BRCA1/2 mutation analysis in Indonesian hereditary breast cancer revealed frequent variants of uncertain significance Open

Samuel J Haryono, S. Utami · 2016

A comprehensive exploration of Java man: bio-cultural evolution from Homo Erectus to Homo Sapiens Open

Samuel J Haryono, Sri Utami, Restu Ambar Rahayuningsih · 2016

\nAn overlap of time period between Homo erectus and Homo sapiens has not been confirmed. In the history of man, there have been two missing links: one between man and ape, and one between progressive Homo erectus and archaic Homo sapiens.…

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