Samuel V. Kemp
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View article: Single-Cell RNA-seq Reveals Aberrant Airway Epithelial-Immune Cell Crosstalk In Pulmonary Fibrosis
Single-Cell RNA-seq Reveals Aberrant Airway Epithelial-Immune Cell Crosstalk In Pulmonary Fibrosis Open
Background Epithelial-immune cell interactions are crucial in the regulation of pulmonary immune responses. Emerging evidence suggests that cell populations lining the airways may play a pivotal role in the pathogenesis of idiopathic pulmo…
View article: Evaluation of the safety of short-term follow-up CT for the management of consolidation in lung cancer screening
Evaluation of the safety of short-term follow-up CT for the management of consolidation in lung cancer screening Open
Objectives Focal consolidation on CT may be inflammatory or malignant, and PET-CT imaging is rarely discriminatory. Furthermore, consolidation may demonstrate spontaneous resolution obviating the need for PET-CT imaging. This retrospective…
View article: Impaired antiviral immunity in frequent exacerbators of chronic obstructive pulmonary disease
Impaired antiviral immunity in frequent exacerbators of chronic obstructive pulmonary disease Open
COPD exacerbations are commonly triggered by viral infections. Some patients with COPD have frequent exacerbations leading to rapid lung function decline and increased mortality. In this study, antiviral responses (interferons) from bronch…
View article: Embodied Carbon Impacts of Building Envelope Systems
Embodied Carbon Impacts of Building Envelope Systems Open
As buildings become more energy efficient due to stringent building codes, the emphasis on reducing the embodied carbon (EC) in the built environment has become significant. Studies predict that between 2020 and 2050, new buildings will su…
View article: Survival following lung volume reduction procedures: results from the UK Lung Volume Reduction (UKLVR) registry
Survival following lung volume reduction procedures: results from the UK Lung Volume Reduction (UKLVR) registry Open
Introduction Lung volume reduction surgery (LVRS) and endobronchial valve (EBV) placement can produce substantial benefits in appropriately selected people with emphysema. The UK Lung Volume Reduction (UKLVR) registry is a national multice…
View article: Lung extracellular matrix modulates KRT5+ basal cell activity in pulmonary fibrosis
Lung extracellular matrix modulates KRT5+ basal cell activity in pulmonary fibrosis Open
Aberrant expansion of KRT5 + basal cells in the distal lung accompanies progressive alveolar epithelial cell loss and tissue remodelling during fibrogenesis in idiopathic pulmonary fibrosis (IPF). The mechanisms determining activity of KRT…
View article: Lung volume reduction surgery<i>versus</i>endobronchial valves: a randomised controlled trial
Lung volume reduction surgery<i>versus</i>endobronchial valves: a randomised controlled trial Open
Background Lung volume reduction surgery (LVRS) and bronchoscopic lung volume reduction (BLVR) with endobronchial valves can improve outcomes in appropriately selected patients with emphysema. However, no direct comparison data exist to in…
View article: Lung extracellular matrix modulates KRT5<sup>+</sup>basal cell activity in pulmonary fibrosis
Lung extracellular matrix modulates KRT5<sup>+</sup>basal cell activity in pulmonary fibrosis Open
Aberrant expansion of KRT5 + basal cells in the distal lung accompanies progressive alveolar epithelial cell loss and tissue remodelling during fibrogenesis in idiopathic pulmonary fibrosis (IPF). The mechanisms determining activity of KRT…
View article: A radiomics-based decision support tool improves lung cancer diagnosis in combination with the Herder score in large lung nodules
A radiomics-based decision support tool improves lung cancer diagnosis in combination with the Herder score in large lung nodules Open
This project represents independent research funded by: 1) Royal Marsden Partners Cancer Alliance, 2) the Royal Marsden Cancer Charity, 3) the National Institute for Health Research (NIHR) Biomedical Research Centre at the Royal Marsden NH…
View article: Lung cancer screening provides an opportunity for early diagnosis and treatment of interstitial lung disease
Lung cancer screening provides an opportunity for early diagnosis and treatment of interstitial lung disease Open
Interstitial lung abnormalities (ILA) can be incidentally detected in patients undergoing low-dose CT screening for lung cancer. In this retrospective study, we explore the downstream impact of ILA detection on interstitial lung disease (I…
View article: Immediate, remote smoking cessation intervention in participants undergoing a targeted lung health check: QuLIT2 a randomised controlled trial
Immediate, remote smoking cessation intervention in participants undergoing a targeted lung health check: QuLIT2 a randomised controlled trial Open
Background Lung cancer screening programs provide an opportunity to support smokers to quit, but the most appropriate model for delivery remains to be determined. Immediate face to face smoking cessation support for people undergoing scree…
View article: Immediate smoking cessation support versus usual care in smokers attending a targeted lung health check: the QuLIT trial
Immediate smoking cessation support versus usual care in smokers attending a targeted lung health check: the QuLIT trial Open
Objectives Lung cancer screening programmes offer an opportunity to address tobacco dependence in current smokers. The effectiveness of different approaches to smoking cessation in this context has not yet been established. We investigated…
View article: A randomised controlled trial of intrapleural balloon intercostal chest drains to prevent drain displacement
A randomised controlled trial of intrapleural balloon intercostal chest drains to prevent drain displacement Open
Background Chest drain displacement is a common clinical problem that occurs in 9–42% of cases and results in treatment failure or additional pleural procedures conferring unnecessary risk. A novel chest drain with an integrated intrapleur…
View article: P4 Lung cancer screening provides a unique opportunity for early diagnosis and management of interstitial lung diseases
P4 Lung cancer screening provides a unique opportunity for early diagnosis and management of interstitial lung diseases Open
Background Early detection and treatment of lung cancer through low- dose computed tomography (LDCT) screening reduces lung cancer mortality. Undiagnosed interstitial lung disease (ILD) can be incidentally detected on LDCT, but whether thi…
View article: Defining growth in small pulmonary nodules using volumetry: results from a “coffee-break” CT study and implications for current nodule management guidelines
Defining growth in small pulmonary nodules using volumetry: results from a “coffee-break” CT study and implications for current nodule management guidelines Open
Objectives An increase in lung nodule volume on serial CT may represent true growth or measurement variation. In nodule guidelines, a 25% increase in nodule volume is frequently used to determine that growth has occurred; this is based on …
View article: Detection and diagnosis of large airway collapse: a systematic review
Detection and diagnosis of large airway collapse: a systematic review Open
Large airway collapse (LAC) is a frequently encountered clinical problem, caused by tracheobronchomalacia +/− excessive dynamic airway collapse, yet there are currently no universally accepted diagnostic criteria. We systematically reviewe…
View article: Endobronchial Valve Lung Volume Reduction and Small Airway Function
Endobronchial Valve Lung Volume Reduction and Small Airway Function Open
"Endobronchial Valve Lung Volume Reduction and Small Airway Function." American Journal of Respiratory and Critical Care Medicine, 203(12), pp. 1576–1579
View article: Intra-alveolar neutrophil-derived microvesicles are associated with disease severity in COPD
Intra-alveolar neutrophil-derived microvesicles are associated with disease severity in COPD Open
Despite advances in the pathophysiology of chronic obstructive pulmonary disease (COPD), there is a distinct lack of biochemical markers to aid clinical management. Microvesicles (MVs) have been implicated in the pathophysiology of inflamm…
View article: Lung volume reduction eligibility in patients with COPD completing pulmonary rehabilitation: results from the UK National Asthma and COPD Audit Programme
Lung volume reduction eligibility in patients with COPD completing pulmonary rehabilitation: results from the UK National Asthma and COPD Audit Programme Open
Objectives To establish what proportion of patients completing a UK pulmonary rehabilitation (PR) programme meet the 2018 National Institute for Health and Care Excellence (NICE) chronic obstructive pulmonary disease (COPD) guideline (NG11…
View article: Bronchial Thermoplasty Induced Airway Smooth Muscle Reduction and Clinical Response in Severe Asthma. The TASMA Randomized Trial
Bronchial Thermoplasty Induced Airway Smooth Muscle Reduction and Clinical Response in Severe Asthma. The TASMA Randomized Trial Open
Rationale: Bronchial thermoplasty (BT) is a bronchoscopic treatment for severe asthma targeting airway smooth muscle (ASM). Observational studies have shown ASM mass reduction after BT, but appropriate control groups are lacking. Furthermo…
View article: Inhaled corticosteroids downregulate the SARS-CoV-2 receptor ACE2 in COPD through suppression of type I interferon
Inhaled corticosteroids downregulate the SARS-CoV-2 receptor ACE2 in COPD through suppression of type I interferon Open
Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 is a new rapidly spreading infectious disease. Early reports of hospitalised COVID-19 cases have shown relatively low frequency of chronic lung diseases such as chronic obstructive p…