Samuel Le Goff
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View article: Replication-independent eviction of H2B.8 reveals chromatin reprogramming during seed imbibition
Replication-independent eviction of H2B.8 reveals chromatin reprogramming during seed imbibition Open
The transition from seed to seedling involves major changes in nuclear organization and gene expression, yet the extent to which this developmental transition requires chromatin reprogramming remains largely unexplored. Here, we report tha…
View article: Ubiquitin-dependent proteolysis of KNL2 driven by APC/CCDC20 is critical for centromere integrity and mitotic fidelity
Ubiquitin-dependent proteolysis of KNL2 driven by APC/CCDC20 is critical for centromere integrity and mitotic fidelity Open
Kinetochores are large protein complexes that serve as attachment sites for spindle microtubules, ensuring proper chromosome segregation during cell division. KINETOCHORE NULL2 (αKNL2) is a key kinetochore protein required for the incorpor…
View article: The histone chaperones <scp>ASF1</scp> and <scp>HIRA</scp> are required for telomere length and <scp>45S rDNA</scp> copy number homeostasis
The histone chaperones <span>ASF1</span> and <span>HIRA</span> are required for telomere length and <span>45S rDNA</span> copy number homeostasis Open
SUMMARY Genome stability is significantly influenced by the precise coordination of chromatin complexes that facilitate the loading and eviction of histones from chromatin during replication, transcription, and DNA repair processes. In thi…
View article: Distinct clades of TELOMERE REPEAT BINDING transcriptional regulators interplay to regulate plant development
Distinct clades of TELOMERE REPEAT BINDING transcriptional regulators interplay to regulate plant development Open
TELOMERE REPEAT BINDING proteins (TRBs) are plant-specific transcriptional regulators that combine two DNA-binding domains, the GH1 domain shared with H1 histones that binds to linker DNA and the Myb/SANT domain that specifically recognize…
View article: The H3 histone chaperone NASP<sup>SIM3</sup> escorts CenH3 in Arabidopsis
The H3 histone chaperone NASP<sup>SIM3</sup> escorts CenH3 in Arabidopsis Open
Summary Centromeres define the chromosomal position where kinetochores form to link the chromosome to microtubules during mitosis and meiosis. Centromere identity is determined by incorporation of a specific histone H3 variant termed CenH3…
View article: Replication‐coupled histone H3.1 deposition determines nucleosome composition and heterochromatin dynamics during Arabidopsis seedling development
Replication‐coupled histone H3.1 deposition determines nucleosome composition and heterochromatin dynamics during Arabidopsis seedling development Open
Summary Developmental phase transitions are often characterized by changes in the chromatin landscape and heterochromatin reorganization. In Arabidopsis, clustering of repetitive heterochromatic loci into so‐called chromocenters is an impo…
View article: Genetic and epigenetic variation in 5S ribosomal RNA genes reveals genome dynamics in Arabidopsis thaliana
Genetic and epigenetic variation in 5S ribosomal RNA genes reveals genome dynamics in Arabidopsis thaliana Open
Organized in tandem repeat arrays in most eukaryotes and transcribed by RNA polymerase III, expression of 5S rRNA genes is under epigenetic control. To unveil mechanisms of transcriptional regulation, we obtained here in depth sequence inf…
View article: Arabidopsis ATRX Modulates H3.3 Occupancy and Fine-Tunes Gene Expression
Arabidopsis ATRX Modulates H3.3 Occupancy and Fine-Tunes Gene Expression Open
Histones are essential components of the nucleosome, the major chromatin subunit that structures linear DNA molecules and regulates access of other proteins to DNA. Specific histone chaperone complexes control the correct deposition of can…
View article: The histone chaperone complex <scp>HIR</scp> maintains nucleosome occupancy and counterbalances impaired histone deposition in <scp>CAF</scp>‐1 complex mutants
The histone chaperone complex <span>HIR</span> maintains nucleosome occupancy and counterbalances impaired histone deposition in <span>CAF</span>‐1 complex mutants Open
Summary Chromatin organization is essential for coordinated gene expression, genome stability, and inheritance of epigenetic information. The main components involved in chromatin assembly are specific complexes such as Chromatin Assembly …