Samuel Liver
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View article: Phenotype-directed discovery of diverse, biologically-relevant molecular scaffolds
Phenotype-directed discovery of diverse, biologically-relevant molecular scaffolds Open
An array of reactions of diazo substrates with many possible outcomes was executed, and the biological relevance of the resulting products assessed in the cell painting assay.
View article: Discovery of photocatalytic reactions enabled by high-throughput experimentation
Discovery of photocatalytic reactions enabled by high-throughput experimentation Open
The discovery of photocatalysed reactions involving many different substrate classes has significantly expanded accessible chemical space. However, the rational design of new classes of photocatalytic reactions can be hindered by their mec…
View article: Activity‐Directed Synthesis: A Flexible Approach for Lead Generation
Activity‐Directed Synthesis: A Flexible Approach for Lead Generation Open
Activity‐directed synthesis (ADS) is a structure‐blind, functional‐driven molecular discovery approach. In this Concept, four case studies highlight the general applicability of ADS and showcase its flexibility to support different medicin…
View article: Efficient Approaches for the Synthesis of Diverse α-Diazo Amides
Efficient Approaches for the Synthesis of Diverse α-Diazo Amides Open
Metal-catalysed carbenoid chemistry can be exploited for the synthesis of diverse ranges of small molecules from α-diazo carbonyl compounds. In this paper, three synthetic approaches to α-diazo amides are described, and their scope and lim…