Explanipedia

Surgical Removal of Visceral Adipose Tissue has Therapeutic Benefit in Male APP<sup>NL-F</sup> Mice Open

Samuel McFadden, Yimin Fang, Kathleen Quinn, Mackenzie R. Peck, Jenelle E. Chapman , et al. · 2025

Purpose Visceral white adipose tissue (vWAT) accumulation causes systemic inflammation, insulin resistance, metabolic syndrome, and senescent cell accumulation that are risk factors for Alzheimer’s disease (AD). Visceral fat removal (VFR) …

Sexual dimorphic synaptic dysfunction and cognition in a mouse model of Alzheimer’s disease Open

Caleigh A. Findley, Samuel McFadden, Tiarra Hill, Mackenzie R. Peck, Kathleen Quinn , et al. · 2024

Background Glutamatergic neurotransmission plays an essential role in learning and memory. Previous studies support a dynamic shift in excitatory signaling with Alzheimer’s disease (AD) progression, contributing to negative cognitive outco…

Thermotherapy has sexually dimorphic responses in APP/PS1 mice Open

Samuel McFadden, Mackenzie R. Peck, Lindsey N. Sime, MaKayla F. Cox, Erol D. Ikiz , et al. · 2024

A thermoregulatory decline occurs with age due to changes in muscle mass, vasoconstriction, and metabolism that lowers core body temperature (Tc). Although lower Tc is a biomarker of successful aging, we have previously shown this worsens …

Sexual dimorphism, altered hippocampal glutamatergic neurotransmission, and cognitive impairment in APP knock-in mice Open

Caleigh A. Findley, Samuel McFadden, Tiarra Hill, Mackenzie R. Peck, Kathleen Quinn , et al. · 2024

Background It is well established that glutamatergic neurotransmission plays an essential role in learning and memory. Previous studies indicate that glutamate dynamics shift with Alzheimer's disease (AD) progression, contributing to negat…

Senolytic intervention improves cognition, metabolism, and adiposity in female APPNL−F/NL−F mice Open

Yimin Fang, Mackenzie R. Peck, Kathleen Quinn, Jenelle E. Chapman, David X. Medina , et al. · 2024

Early life interventions metformin and trodusquemine metabolically reprogram the developing mouse liver through transcriptomic alterations Open

Sarah Ashiqueali, Augusto Schneider, Xiang Zhu, Ewelina Juszczyk, Mishfak A. M. Mansoor , et al. · 2024

Recent studies have demonstrated the remarkable potential of early life intervention strategies at influencing the course of postnatal development, thereby offering exciting possibilities for enhancing longevity and improving overall healt…

Thermotherapy has Sexually Dimorphic Responses in APP/PS1 Mice Open

Samuel McFadden, Mackenzie R. Peck, Lindsey N. Sime, MaKayla F. Cox, Erol D. Ikiz , et al. · 2024

A thermoregulatory decline occurs with age due to changes in muscle mass, vasoconstriction, and metabolism that lowers core body temperature (Tc). Although lower Tc is a biomarker of successful aging, we have previously shown this worsens …

Senolytic Intervention Improves Cognition, Metabolism, and Adiposity in Female APP<sup>NL-F/NL-F</sup>Mice Open

Yimin Fang, Mackenzie R. Peck, Kathleen Quinn, Jenelle E. Chapman, David X. Medina , et al. · 2023

Senescent cells accumulate throughout the body and brain contributing to unhealthy aging and Alzheimer’s disease (AD). The APP NL-F/NL-F amyloidogenic AD mouse model exhibits increased markers of senescent cells and the senescence-associat…

Sexual Dimorphism, Altered Hippocampal Glutamatergic Neurotransmission and Cognitive Impairment in APP Knock-In Mice Open

Caleigh A. Findley, Samuel McFadden, Tiarra Hill, Mackenzie R. Peck, Kathleen Quinn , et al. · 2023

Background It is well established that glutamatergic neurotransmission plays an essential role in learning and memory. Previous studies indicate that glutamate dynamics shift with Alzheimer’s disease (AD) progression, contributing to negat…

Sexual dimorphic metabolic and cognitive responses of C57BL/6 mice to Fisetin or Dasatinib and quercetin cocktail oral treatment Open

Yimin Fang, David Medina, Robert Stockwell, Samuel McFadden, Kathleen Quinn , et al. · 2023

Senolytic treatment in aged mice clears senescent cell burden leading to functional improvements. However, less is known regarding the effects of these compounds when administered prior to significant senescent cell accumulation. From 4–13…

Prodromal Glutamatergic Modulation with Riluzole Impacts Glucose Homeostasis and Spatial Cognition in Alzheimer’s Disease Mice Open

Caleigh A. Findley, Samuel McFadden, MaKayla F. Cox, Lindsey N. Sime, Mackenzie R. Peck , et al. · 2023

Background: Prior research supports a strong link between Alzheimer’s disease (AD) and metabolic dysfunction that involves a multi-directional interaction between glucose, glutamatergic homeostasis, and amyloid pathology. Elevated soluble …

Resistance to mild cold stress is greater in both wild-type and long-lived GHR-KO female mice Open

Yimin Fang, David Medina, Robert Stockwell, Samuel McFadden, Erin R. Hascup , et al. · 2022

Chronic, Mild Hypothermic Environmental Temperature Does Not Ameliorate Cognitive Deficits in an Alzheimer’s Disease Mouse Open

Samuel McFadden, Lindsey N. Sime, MaKayla F Cox, Caleigh A. Findley, Mackenzie R. Peck , et al. · 2022

Metabolic dysfunction increases with age and is a contributing factor to Alzheimer’s disease (AD) development. We have previously observed impaired insulin sensitivity and glucose homeostasis in the APP/PS1 model of AD. To improve these pa…

Sexual Dimorphic Metabolic and Cognitive Responses of C57BL/6 Mice to Fisetin or Dasatinib and Quercetin Cocktail Oral Treatment Open

Yimin Fang, David Medina, Robert Stockwell, Samuel McFadden, Kathleen Quinn , et al. · 2021

Senolytic treatment in aged mice clears senescent cell burden leading to functional improvements. However, less is known regarding the effects of these compounds when administered prior to significant senescent cell accumulation. From 4-13…

Growth Hormone Signaling Shapes the Impact of Environmental Temperature on Transcriptomic Profile of Different Adipose Tissue Depots in Male Mice Open

Augusto Schneider, Berta Victoria, Maria Isabel Schiavon Cousen, Yimin Fang, Samuel McFadden , et al. · 2021

Growth hormone receptor knockout (GHRKO) mice are smaller, long living, and have an increased metabolic rate compared with normal (N) littermates. However, it is known that thermoneutral conditions (30–32°C) elicit metabolic adaptations in…

Growth hormone increases DNA damage in ovarian follicles and macrophage infiltration in the ovaries Open

Tatiana D. Saccon, Monique Tomazele Rovani, Driele N. Garcia, Jorgea Pradieé, Rafael Gianella Mondadori , et al. · 2021

Alzheimer’s disease‐related sex differences in insulin sensitivity, glucose metabolism, and spatial memory Open

Caleigh A. Findley, Lindsey N. Sime, Samuel McFadden, Kevin N. Hascup, Andrzej Bartke , et al. · 2020

Background Women are at higher risk for developing Alzheimer’s disease (AD), comprising two‐thirds of AD patients. In this study, we aimed to characterize AD‐related sex differences in insulin sensitivity, glucose tolerance, and spatial le…

17α-Estradiol Modulates IGF1 and Hepatic Gene Expression in a Sex-Specific Manner Open

Silvana Sidhom, Augusto Schneider, Yimin Fang, Samuel McFadden, Justin Darcy , et al. · 2020

Aging is the greatest risk factor for most chronic diseases. The somatotropic axis is one of the most conserved biological pathways that regulates aging across species. 17α-Estradiol (17α-E2), a diastereomer of 17β-estradiol (17β-E2), was …

Integrated metabolomics reveals altered lipid metabolism in adipose tissue in a model of extreme longevity Open

Justin Darcy, Yimin Fang, Samuel McFadden, Matthew D. Lynes, Luiz Osório Leiria , et al. · 2020

Lifespan of long‐lived growth hormone receptor knockout mice was not normalized by housing at 30°C since weaning Open

Yimin Fang, Samuel McFadden, Justin Darcy, Erin R. Hascup, Kevin N. Hascup , et al. · 2020

Growth hormone receptor knockout (GHRKO) mice are remarkably long‐lived and have improved glucose homeostasis along with altered energy metabolism which manifests through decreased respiratory quotient (RQ) and increased oxygen consumption…

DNA damage and macrophage infiltration in the ovaries of the long-lived GH deficient Ames Dwarf and the short-lived bGH transgenic mice Open

Tatiana D. Saccon, Monique Tomazele Rovani, Driele N. Garcia, Jorgea Pradieé, Rafael Gianella Mondadori , et al. · 2020

Objective The aim of the study was to evaluate the role of growth hormone (GH) in DNA damage, macrophage infiltration and the granulosa cells number of primordial and primary follicles. Methods For these experiments six groups of female mi…

Increased environmental temperature normalizes energy metabolism outputs between normal and Ames dwarf mice Open

Justin Darcy, Samuel McFadden, Yimin Fang, Darlene E. Berryman, Edward O. List , et al. · 2018

Ames dwarf (Prop1^df) mice possess a loss-of-function mutation that results in deficiency of growth hormone, prolactin, and thyroid-stimulating hormone, as well as exceptional longevity. Work in other laboratories suggests…

Effects of rapamycin on growth hormone receptor knockout mice Open

Yimin Fang, Cristal M. Hill, Justin Darcy, Adriana Reyes‐Ordoñez, Edwin Araúz , et al. · 2018

Significance In various animal species, including mammals, longevity can be extended by rapamycin, an inhibitor of mTOR (mechanistic target of rapamycin). mTOR acts through two complexes: mTORC1 and mTORC2. Antiaging effects of rapamycin a…

Longevity is impacted by growth hormone action during early postnatal period Open

Liou Y. Sun, Yimin Fang, Amit Patki, Jacob J.E. Koopman, David B. Allison , et al. · 2017

Life-long lack of growth hormone (GH) action can produce remarkable extension of longevity in mice. Here we report that GH treatment limited to a few weeks during development influences the lifespan of long-lived Ames dwarf and normal litt…

Author response: Longevity is impacted by growth hormone action during early postnatal period Open

Liou Y. Sun, Yimin Fang, Amit Patki, Jacob J.E. Koopman, David B. Allison , et al. · 2017

Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract Life-long lack of growth hormone (GH) action ca…

Differential effects of early-life nutrient restriction in long-lived GHR-KO and normal mice Open

Yimin Fang, Samuel McFadden, Justin Darcy, Cristal M. Hill, J Huber , et al. · 2017

Altered structure and function of adipose tissue in long-lived mice with growth hormone-related mutations Open

Justin Darcy, Samuel McFadden, Andrzej Bartke · 2017

A major focus of biogerontology is elucidating the role(s) of the endocrine system in aging and the accumulation of age-related diseases. Endocrine control of mammalian longevity was first reported in Ames dwarf (Prop1^df) mice, …

Brown Adipose Tissue Function Is Enhanced in Long-Lived, Male Ames Dwarf Mice Open

Justin Darcy, Samuel McFadden, Yimin Fang, J Huber, Chi Zhang , et al. · 2016

Ames dwarf mice (Prop1^df/df) are long-lived due to a loss of function mutation, resulting in deficiency of GH, TSH, and prolactin. Along with a marked extension of longevity, Ames dwarf mice have improved energy metabolism as me…

Original Research: Metabolic alterations from early life thyroxine replacement therapy in male Ames dwarf mice are transient Open

Justin Darcy, Yimin Fang, Cristal M. Hill, Samuel McFadden, Liou Y. Sun , et al. · 2016

Ames dwarf mice are exceptionally long-lived due to a Prop1 loss of function mutation resulting in deficiency of growth hormone, thyroid-stimulating hormone and prolactin. Deficiency in thyroid-stimulating hormone and growth hormone leads …

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