Samuel P. Rosin
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View article: Differences in Prevalence and Incidence of Electrocardiogram Abnormalities and Cardiovascular Autonomic Neuropathy Among Randomized Glucose-lowering Treatments in Early Type 2 Diabetes: The Glycemia Reduction Approaches in Diabetes (GRADE) Cohort
Differences in Prevalence and Incidence of Electrocardiogram Abnormalities and Cardiovascular Autonomic Neuropathy Among Randomized Glucose-lowering Treatments in Early Type 2 Diabetes: The Glycemia Reduction Approaches in Diabetes (GRADE) Cohort Open
Objective: To describe prevalence and incidence of electrocardiogram (ECG) abnormalities and ECG-derived cardiovascular autonomic neuropathy (CAN) in the GRADE cohort of adults with type 2 diabetes (T2D) Research Design and Methods: T2D in…
View article: Differences in Prevalence and Incidence of Electrocardiogram Abnormalities and Cardiovascular Autonomic Neuropathy Among Randomized Glucose-lowering Treatments in Early Type 2 Diabetes: The Glycemia Reduction Approaches in Diabetes (GRADE) Cohort
Differences in Prevalence and Incidence of Electrocardiogram Abnormalities and Cardiovascular Autonomic Neuropathy Among Randomized Glucose-lowering Treatments in Early Type 2 Diabetes: The Glycemia Reduction Approaches in Diabetes (GRADE) Cohort Open
Objective: To describe prevalence and incidence of electrocardiogram (ECG) abnormalities and ECG-derived cardiovascular autonomic neuropathy (CAN) in the GRADE cohort of adults with type 2 diabetes (T2D) Research Design and Methods: T2D in…
View article: Differential Treatment Effects on β-Cell Function Using Model-Based Parameters in Type 2 Diabetes: Results From the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE)
Differential Treatment Effects on β-Cell Function Using Model-Based Parameters in Type 2 Diabetes: Results From the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE) Open
OBJECTIVE To evaluate how model-based parameters of β-cell function change with glucose-lowering treatment and associate with glycemic deterioration in adults with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS In the Glycemia Reductio…
View article: Differential Treatment Effects on β-cell Function Using Model-based Parameters in Type 2 Diabetes: Results from the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness (GRADE) Study
Differential Treatment Effects on β-cell Function Using Model-based Parameters in Type 2 Diabetes: Results from the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness (GRADE) Study Open
Objective: Evaluate how model-based parameters of β-cell function change with glucose-lowering treatment and associate with glycemic deterioration in adults with type 2 diabetes (T2D).Research Design and Methods: In the GRADE…
View article: The Relationship between Average Glucose Levels and HbA1c Differs Across Racial Groups: A Sub-study of the GRADE Randomized Trial
The Relationship between Average Glucose Levels and HbA1c Differs Across Racial Groups: A Sub-study of the GRADE Randomized Trial Open
Objective: To determine whether the relationship between average glycemia (AG) levels and HbA1c differs across racial/ethnic groups.Research Design and Methods: A prospective sub-study of GRADE, a comparative effectiveness randomized trial…
View article: The Association of Baseline Factors with Glycemic Outcomes in the GRADE Study: A Comparative Effectiveness Randomized Clinical Trial
The Association of Baseline Factors with Glycemic Outcomes in the GRADE Study: A Comparative Effectiveness Randomized Clinical Trial Open
Objective: To describe the individual and joint associations of baseline factors with glycemia, and with differential effectiveness of medications added to metformin. Research Design and Methods: GRADE participants (type 2 diabetes for Res…
View article: Association of Baseline Factors With Glycemic Outcomes in GRADE: A Comparative Effectiveness Randomized Clinical Trial
Association of Baseline Factors With Glycemic Outcomes in GRADE: A Comparative Effectiveness Randomized Clinical Trial Open
OBJECTIVE To describe the individual and joint associations of baseline factors with glycemia, and also with differential effectiveness of medications added to metformin. RESEARCH DESIGN AND METHODS Glycemia Reduction Approaches in Diabete…
View article: The Association of Baseline Factors with Glycemic Outcomes in the GRADE Study: A Comparative Effectiveness Randomized Clinical Trial
The Association of Baseline Factors with Glycemic Outcomes in the GRADE Study: A Comparative Effectiveness Randomized Clinical Trial Open
Objective: To describe the individual and joint associations of baseline factors with glycemia, and with differential effectiveness of medications added to metformin. Research Design and Methods: GRADE participants (type 2 diabetes for Res…
View article: Fusing trial data for treatment comparisons: Single vs multi‐span bridging
Fusing trial data for treatment comparisons: Single vs multi‐span bridging Open
While randomized controlled trials (RCTs) are critical for establishing the efficacy of new therapies, there are limitations regarding what comparisons can be made directly from trial data. RCTs are limited to a small number of comparator …
View article: Estimating SARS-CoV-2 seroprevalence
Estimating SARS-CoV-2 seroprevalence Open
Governments and public health authorities use seroprevalence studies to guide responses to the COVID-19 pandemic. Seroprevalence surveys estimate the proportion of individuals who have detectable SARS-CoV-2 antibodies. However, serologic a…
View article: Fusing Trial Data for Treatment Comparisons: Single versus Multi-Span Bridging
Fusing Trial Data for Treatment Comparisons: Single versus Multi-Span Bridging Open
While randomized controlled trials (RCTs) are critical for establishing the efficacy of new therapies, there are limitations regarding what comparisons can be made directly from trial data. RCTs are limited to a small number of comparator …
View article: Cole et al. Respond to “Combining Information From Diverse Sources”
Cole et al. Respond to “Combining Information From Diverse Sources” Open
Journal Article Accepted manuscript Rejoinder: Combining Information with Fusion Designs, and Roses by Other Names Get access Stephen R Cole, Stephen R Cole Correspondence to Dr. Steve R. Cole, Department of Epidemiology, University of Nor…
View article: Estimating SARS-CoV-2 seroprevalence
Estimating SARS-CoV-2 seroprevalence Open
Governments and public health authorities use seroprevalence studies to guide responses to the COVID-19 pandemic. Seroprevalence surveys estimate the proportion of individuals who have detectable SARS-CoV-2 antibodies. However, serologic a…
View article: Illustration of 2 Fusion Designs and Estimators
Illustration of 2 Fusion Designs and Estimators Open
"Fusion" study designs combine data from different sources to answer questions that could not be answered (as well) by subsets of the data. Studies that augment main study data with validation data, as in measurement-error correction studi…
View article: Fusing trial data for treatment comparisons: Single vs multi-span bridging
Fusing trial data for treatment comparisons: Single vs multi-span bridging Open
While randomized controlled trials (RCTs) are critical for establishing the efficacy of new therapies, there are limitations regarding what comparisons can be made directly from trial data. RCTs are limited to a small number of comparator …
View article: Illustration of 2 Fusion Designs and Estimators
Illustration of 2 Fusion Designs and Estimators Open
“Fusion” study designs combine data from different sources to answer questions that could not be answered (as well) by subsets of the data. Studies that augment main study data with validation data, as in measurement-error correction studi…
View article: Estimating SARS-CoV-2 Seroprevalence
Estimating SARS-CoV-2 Seroprevalence Open
Governments and public health authorities use seroprevalence studies to guide responses to the COVID-19 pandemic. Seroprevalence surveys estimate the proportion of individuals who have detectable SARS-CoV-2 antibodies. However, serologic a…
View article: Infant gut microbiome composition is associated with non-social fear behavior in a pilot study
Infant gut microbiome composition is associated with non-social fear behavior in a pilot study Open
View article: Inverse probability weighted estimators of vaccine effects accommodating partial interference and censoring
Inverse probability weighted estimators of vaccine effects accommodating partial interference and censoring Open
Estimating population‐level effects of a vaccine is challenging because there may be interference, that is, the outcome of one individual may depend on the vaccination status of another individual. Partial interference occurs when individu…
View article: Infant gut microbiome composition is associated with non-social fear behavior in a pilot study
Infant gut microbiome composition is associated with non-social fear behavior in a pilot study Open
Experimental manipulation of gut microbes in animal models alters fear behavior and relevant neurocircuitry. In humans, the first year of life is a key period for brain development, the emergence of fearfulness, and the establishment of th…
View article: A preliminary study of gut microbiome variation and HPA axis reactivity in healthy infants
A preliminary study of gut microbiome variation and HPA axis reactivity in healthy infants Open
View article: SARS-CoV-2 Seroprevalence among a Southern U.S. Population Indicates Limited Asymptomatic Spread under Physical Distancing Measures
SARS-CoV-2 Seroprevalence among a Southern U.S. Population Indicates Limited Asymptomatic Spread under Physical Distancing Measures Open
This study suggests limited but accelerating asymptomatic spread of SARS-CoV-2. Asymptomatic infections, like symptomatic infections, disproportionately affected vulnerable communities in this population, and seroprevalence was higher in A…
View article: SARS-CoV-2 seroprevalence among a southern U.S. population indicates limited asymptomatic spread under physical distancing measures
SARS-CoV-2 seroprevalence among a southern U.S. population indicates limited asymptomatic spread under physical distancing measures Open
Characterizing the asymptomatic spread of SARS-CoV-2 is important for understanding the COVID-19 pandemic. This study was aimed at determining asymptomatic spread of SARS-CoV-2 in a suburban, Southern U.S. population during a period of sta…
View article: A preliminary study of gut microbiome variation and HPA axis reactivity in healthy infants
A preliminary study of gut microbiome variation and HPA axis reactivity in healthy infants Open
The Hypothalamic Pituitary Adrenal (HPA) axis regulates hormonal responses to stress in both humans and animals and is dysregulated in a wide range of psychiatric disorders. There is strong evidence from rodent studies that gut microbial c…