Samuel R. Dominguez
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View article: Using COVID-19 pandemic perturbation to model RSV-hMPV interactions and potential implications under RSV interventions
Using COVID-19 pandemic perturbation to model RSV-hMPV interactions and potential implications under RSV interventions Open
View article: Dynamics of endemic virus re-emergence in children in the USA following the COVID-19 pandemic (2022–23): a prospective, multicentre, longitudinal, immunoepidemiological surveillance study
Dynamics of endemic virus re-emergence in children in the USA following the COVID-19 pandemic (2022–23): a prospective, multicentre, longitudinal, immunoepidemiological surveillance study Open
View article: Return of the Biennial Circulation of Enterovirus D68 in Colorado Children in 2024 Following the Large 2022 Outbreak
Return of the Biennial Circulation of Enterovirus D68 in Colorado Children in 2024 Following the Large 2022 Outbreak Open
Enterovirus D68 (EV-D68) caused large biennial cyclical outbreaks of respiratory disease and cases of acute flaccid myelitis from 2014 to 2018 in the USA. An anticipated outbreak did not occur in 2020, likely due to non-pharmaceutical inte…
View article: P-2221. Clinical utility and sensitivity of plasma metagenomic microbial cell-free DNA sequencing in children with complicated pneumonia
P-2221. Clinical utility and sensitivity of plasma metagenomic microbial cell-free DNA sequencing in children with complicated pneumonia Open
Background Etiological diagnostics for children with complicated bacterial pneumonia remain limited and insensitive, and pleural fluid (PF) testing is invasive. Plasma metagenomic microbial cell-free DNA (mcfDNA) sequencing, available by K…
View article: 301. Clinical impact of a <i>Streptococcus pneumoniae</i> PCR assay on pleural fluid specimens for children with complicated pneumonia
301. Clinical impact of a <i>Streptococcus pneumoniae</i> PCR assay on pleural fluid specimens for children with complicated pneumonia Open
Background While Streptococcus pneumoniae (Spn) is the predominant pathogen in pediatric complicated community acquired pneumonia (cCAP), it is infrequently recovered by culture-based methods. Without Spn or another pathogen detected, pati…
View article: Predicting the impact of non-pharmaceutical interventions against COVID-19 on Mycoplasma pneumoniae in the United States
Predicting the impact of non-pharmaceutical interventions against COVID-19 on Mycoplasma pneumoniae in the United States Open
The introduction of non-pharmaceutical interventions (NPIs) against COVID-19 disrupted circulation of many respiratory pathogens and eventually caused large, delayed outbreaks, owing to the build up of the susceptible pool during the inter…
View article: Predicting the impact of non-pharmaceutical interventions against COVID-19 on<i>Mycoplasma pneumoniae</i>in the United States
Predicting the impact of non-pharmaceutical interventions against COVID-19 on<i>Mycoplasma pneumoniae</i>in the United States Open
The introduction of non-pharmaceutical interventions (NPIs) against COVID-19 disrupted circulation of many respiratory pathogens and eventually caused large, delayed outbreaks, owing to the build up of the susceptible pool during the inter…
View article: Multimodal Surveillance Model for Enterovirus D68 Respiratory Disease and Acute Flaccid Myelitis among Children in Colorado, USA, 2022
Multimodal Surveillance Model for Enterovirus D68 Respiratory Disease and Acute Flaccid Myelitis among Children in Colorado, USA, 2022 Open
Surveillance for emerging pathogens is critical for developing early warning systems to guide preparedness efforts for future outbreaks of associated disease. To better define the epidemiology and burden of associated respiratory disease a…
View article: Clinical Outcomes Associated with Amoxicillin Treatment for Acute Otitis Media in Children
Clinical Outcomes Associated with Amoxicillin Treatment for Acute Otitis Media in Children Open
Background Acute otitis media (AOM) is the most common reason children are prescribed antibiotics. Bacteria that produce beta-lactamase are an increasingly frequent cause of AOM and may be resistant to amoxicillin, the currently recommende…
View article: 145. Tracheal Aspirate Order Indications and Associated Culture Results in Mechanically Ventilated Children
145. Tracheal Aspirate Order Indications and Associated Culture Results in Mechanically Ventilated Children Open
Background Tracheal aspirates (TAs) are collected on mechanically ventilated patients to aid in diagnosis of tracheitis or ventilator associated pneumonia. Accuracy of TA cultures to diagnose lower respiratory tract infections is low, limi…
View article: 1304. Early Surgical Procedures and Clinical Outcomes Among Children Hospitalized with Acute Hematogenous Osteomyelitis
1304. Early Surgical Procedures and Clinical Outcomes Among Children Hospitalized with Acute Hematogenous Osteomyelitis Open
Background Surgical biopsy and drainage may have diagnostic and therapeutic benefits for children with acute hematogenous osteomyelitis (AHO). However, it remains unknown whether routinely expediting surgical procedures improves clinical o…
View article: 1687. Unprecedented Outbreak of Invasive group A <i>Streptococcus</i> Infections in Children - Colorado, October 2022 to March 2023
1687. Unprecedented Outbreak of Invasive group A <i>Streptococcus</i> Infections in Children - Colorado, October 2022 to March 2023 Open
Background Since the fall of 2022, we have observed a sharp rise in pediatric invasive group A Streptococcus (iGAS) hospitalizations in Colorado, similar to trends reported in other countries. Methods From October 2022 – March 2023, iGAS c…
View article: Development and validation of a multiplex real-time PCR assay for detection and quantification of <i>Streptococcus pneumoniae</i> in pediatric respiratory samples
Development and validation of a multiplex real-time PCR assay for detection and quantification of <i>Streptococcus pneumoniae</i> in pediatric respiratory samples Open
Streptococcus pneumoniae ( Spn ) is a bacterial pathogen that causes a range of disease manifestations in children, from acute otitis media to pneumonia, septicemia, and meningitis. Primary Spn laboratory diagnostic identification methods …
View article: Duration of Enterovirus D68 RNA Shedding in the Upper Respiratory Tract and Transmission among Household Contacts, Colorado, USA
Duration of Enterovirus D68 RNA Shedding in the Upper Respiratory Tract and Transmission among Household Contacts, Colorado, USA Open
Enterovirus D68 (EV-D68) causes cyclical outbreaks of respiratory disease and acute flaccid myelitis. EV-D68 is primarily transmitted through the respiratory route, but the duration of shedding in the respiratory tract is unknown. We prosp…
View article: Reliability of nasopharyngeal PCR for the detection of otopathogens in children with uncomplicated acute otitis media compared to culture
Reliability of nasopharyngeal PCR for the detection of otopathogens in children with uncomplicated acute otitis media compared to culture Open
View article: Qualitative detection of enterovirus D68 from PrimeStore® molecular transport medium: implications for home- and self-collection
Qualitative detection of enterovirus D68 from PrimeStore® molecular transport medium: implications for home- and self-collection Open
View article: Respiratory Syncytial Virus, Influenza, and Coronavirus Disease 2019 Hospitalizations in Children in Colorado During the 2021-2022 Respiratory Virus Season
Respiratory Syncytial Virus, Influenza, and Coronavirus Disease 2019 Hospitalizations in Children in Colorado During the 2021-2022 Respiratory Virus Season Open
View article: Shifting Epidemiology and Severity of Respiratory Syncytial Virus in Children During the COVID-19 Pandemic
Shifting Epidemiology and Severity of Respiratory Syncytial Virus in Children During the COVID-19 Pandemic Open
This cohort study examined changes in RSV age distribution and disease severity in Colorado children after the COVID-19 pandemic.
View article: Development and Validation of a Multiplex Real-Time PCR Assay for Detection and Quantification of<i>Streptococcus pneumoniae</i>in Pediatric Respiratory Samples
Development and Validation of a Multiplex Real-Time PCR Assay for Detection and Quantification of<i>Streptococcus pneumoniae</i>in Pediatric Respiratory Samples Open
Streptococcus pneumoniae ( Spn ) is a bacterial pathogen that causes a range of disease manifestations in children, from acute otitis media to pneumonia, septicemia, and meningitis. Primary Spn laboratory diagnostic identification methods …
View article: 874. Diagnostic Stewardship of Gastrointestinal Multiplex PCR Panels in Hospitalized Children
874. Diagnostic Stewardship of Gastrointestinal Multiplex PCR Panels in Hospitalized Children Open
Background The introduction of multiplex gastrointestinal panels (GIP) led to increased rates of children with stool testing, high rates of negative results, and no change in clinical outcomes for most children. We aimed to reduce overall …
View article: 192. Predictors of Actionable Results on Gastrointestinal Panel Testing for Children Hospitalized with Acute Diarrheal Illnesses
192. Predictors of Actionable Results on Gastrointestinal Panel Testing for Children Hospitalized with Acute Diarrheal Illnesses Open
Background Among hospitalized children with acute diarrheal illnesses, multiplex PCR gastrointestinal panels (GIP) are commonly overused. GIPs are most likely to impact management and outcomes if an actionable (bacterial or parasitic) resu…
View article: 1318. Etiology of Infectious Conjunctivitis in Children: A Multi-Center Case-Controlled Study
1318. Etiology of Infectious Conjunctivitis in Children: A Multi-Center Case-Controlled Study Open
Background Acute infectious conjunctivitis (AIC) is a common pediatric infection affecting one in eight children annually. The etiology of AIC is poorly understood but important to inform treatment and return to school recommendations. Add…
View article: Kathryn V. Holmes: A Career of Contributions to the Coronavirus Field
Kathryn V. Holmes: A Career of Contributions to the Coronavirus Field Open
Over the past two years, scientific research has moved at an unprecedented rate in response to the COVID-19 pandemic. The rapid development of effective vaccines and therapeutics would not have been possible without extensive background kn…
View article: Clinical and Financial Impact of a Diagnostic Stewardship Program for Children with Suspected Central Nervous System Infection
Clinical and Financial Impact of a Diagnostic Stewardship Program for Children with Suspected Central Nervous System Infection Open
View article: Enterovirus D68: a test case for the use of immunological surveillance to develop tools to mitigate the pandemic potential of emerging pathogens
Enterovirus D68: a test case for the use of immunological surveillance to develop tools to mitigate the pandemic potential of emerging pathogens Open
In the autumn of 2014, the USA faced an unexpected spike in cases of previously healthy children stricken with polio-like paralysis following a febrile respiratory illness. Since that time, research efforts have shed light on the causes, m…
View article: COVID-19 and Acute Otitis Media in Children: A Case Series
COVID-19 and Acute Otitis Media in Children: A Case Series Open
Background: The association of SARS-CoV-2 with acute otitis media (AOM) in children is poorly understood. Methods: Cases were identified as a subpopulation within the NO TEARS prospective AOM study in Denver, CO from March to December 2020…
View article: Temporal clustering of Kawasaki disease cases around the world
Temporal clustering of Kawasaki disease cases around the world Open
View article: Genomic Characterization of Group A Streptococci Causing Pharyngitis and Invasive Disease in Colorado, USA, June 2016– April 2017
Genomic Characterization of Group A Streptococci Causing Pharyngitis and Invasive Disease in Colorado, USA, June 2016– April 2017 Open
Background The genomic features and transmission link of circulating Group A Streptococcus (GAS) strains causing different disease types, such as pharyngitis and invasive disease, are not well understood. Methods We used whole-genome seque…
View article: 113. Reliability of Nasopharyngeal PCR for the Detection of Otopathogens in Children with Uncomplicated Acute Otitis Media
113. Reliability of Nasopharyngeal PCR for the Detection of Otopathogens in Children with Uncomplicated Acute Otitis Media Open
Background Among children with acute otitis media (AOM) S.pneumoniae, H.influenzae, and M.catarrhalis are the predominant bacterial otopathogens. There is a high correlation between nasopharyngeal (NP) and middle ear fluid (MEF) organisms …
View article: 347. SARS-CoV-2 and Acute Otitis Media in Children: A Case Series
347. SARS-CoV-2 and Acute Otitis Media in Children: A Case Series Open
Background Reports in adults with COVID-19 and acute otitis media (AOM) show that severe symptoms and hearing loss may be more common than with the clinical presentation of typical AOM. However, the association of SARS-CoV-2 with AOM in ch…