Samuel R. Rodeghiero
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View article: Hypomorphism of a Novel Long ERα Isoform Causes Severe Reproductive Dysfunctions in Female Mice
Hypomorphism of a Novel Long ERα Isoform Causes Severe Reproductive Dysfunctions in Female Mice Open
Estrogen receptor alpha (ERα)–mediated estrogen signaling plays a pivotal role in both reproductive and nonreproductive functions. Transcriptional regulation of the ERα gene is highly complex, with multiple transcript variants being differ…
View article: Use of intraoperative frontal sinus mometasone‐eluting stents decreased interleukin 5 and interleukin 13 in patients with chronic rhinosinusitis with nasal polyps
Use of intraoperative frontal sinus mometasone‐eluting stents decreased interleukin 5 and interleukin 13 in patients with chronic rhinosinusitis with nasal polyps Open
Background Mometasone‐eluting stents (MES) have demonstrated improvement in short‐term endoscopic outcomes and reduce short‐ to medium‐term rescue interventions. Their effect on the local inflammatory environment, longer‐term patient‐repor…
View article: Hypomorphism of a novel long ERα isoform causes severe reproductive dysfunctions in female mice
Hypomorphism of a novel long ERα isoform causes severe reproductive dysfunctions in female mice Open
Estrogen receptor alpha (ERα)-mediated estrogen signaling play a pivotal role in both reproductive and non-reproductive functions. Transcriptional regulation of ERα gene is highly complex, with multiple transcript variants being differenti…
View article: Neuroanatomical organization and functional roles of PVN MC4R pathways in physiological and behavioral regulations
Neuroanatomical organization and functional roles of PVN MC4R pathways in physiological and behavioral regulations Open
Objective The paraventricular nucleus of hypothalamus (PVN) is an integrative center in the brain orchestrating a wide range of physiological and behavioral responses. While the PVN melanocortin 4 receptor (MC4R) signaling (PVN MC4R+ ) is …
View article: Behavioral Alterations in Mice Carrying Homozygous HDAC4A778T Missense Mutation Associated With Eating Disorder
Behavioral Alterations in Mice Carrying Homozygous HDAC4A778T Missense Mutation Associated With Eating Disorder Open
Eating disorders (EDs) are serious mental illnesses thought to arise from the complex gene-environment interactions. DNA methylation patterns in histone deacetylase 4 (HDAC4) locus have been associated with EDs and we have previously ident…