Silke Peter
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Efficacy of cefiderocol in combination with xeruborbactam versus taniborbactam against cefiderocol-resistant NDM-producing <i>Pseudomonas aeruginosa</i> Open
We evaluated the in vitro activity of cefiderocol in combination with either taniborbactam or xeruborbactam against cefiderocol-resistant, bla NDM -positive Pseudomonas aeruginosa clinical isolates from Vietnam and Nigeria. Taniborbactam r…
Combined pathological, microbiological and virological evaluation of vitreous aspirates: a retrospective evaluation of 374 vitrectomy specimens with non-neoplastic disorders Open
Background Intraocular infections pose substantial diagnostic challenges due to their varied aetiologies and complex inflammatory responses. The value of combining cytological, microbiological and virological assessments remains underexplo…
Small intestinal bacterial overgrowth and dysbiosis in children with intestinal failure: A descriptive cohort study Open
Background Small intestinal bacterial overgrowth (SIBO) is a clinical and diagnostic challenge in pediatric intestinal failure. This study aimed to assess SIBO and dysbiosis in children with intestinal failure and to analyze clinical chara…
View article: Prognostic Value of a Multivariate Gut Microbiome Model for Progression from Normal Cognition to Mild Cognitive Impairment Within 4 Years
Prognostic Value of a Multivariate Gut Microbiome Model for Progression from Normal Cognition to Mild Cognitive Impairment Within 4 Years Open
Little is known about the dysbiosis of the gut microbiome in patients with mild cognitive impairment (MCI) potentially at risk for the development of Alzheimer’s disease (AD). So far, only cross-sectional differences and not longitudinal c…
Oxygenation and intestinal perfusion and its association with perturbations of the early life gut microbiota composition of children with congenital heart disease Open
Background Early life gut microbiota is known to shape the immune system and has a crucial role in immune homeostasis. Only little is known about composition and dynamics of the intestinal microbiota in infants with congenital heart diseas…
Metabolic mutations reduce antibiotic susceptibility of E. coli by pathway-specific bottlenecks Open
Metabolic variation across pathogenic bacterial strains can impact their susceptibility to antibiotics and promote the evolution of antimicrobial resistance (AMR). However, little is known about how metabolic mutations influence metabolism…
View article: Gram-negative bloodstream infections in six German university hospitals, 2016–2020: clinical and microbiological features
Gram-negative bloodstream infections in six German university hospitals, 2016–2020: clinical and microbiological features Open
Purpose To analyze the longitudinal epidemiology and antimicrobial resistance (AMR) patterns of Gram-negative bloodstream infections (BSI) in Germany. Methods Post-hoc analysis of prospectively documented BSI due to Escherichia coli , Kleb…
View article: Extended-spectrum beta-lactamase-producing<i>Escherichia coli</i>and<i>Klebsiella pneumoniae</i>from human carriage, the human-polluted environment, and food: molecular epidemiology of two prospective cohorts in five European metropolitan areas
Extended-spectrum beta-lactamase-producing<i>Escherichia coli</i>and<i>Klebsiella pneumoniae</i>from human carriage, the human-polluted environment, and food: molecular epidemiology of two prospective cohorts in five European metropolitan areas Open
Objectives For 475 ESBL-producing Escherichia coli (ESBL-Ec), and 171 ESBL-producing Klebsiella pneumoniae (ESBL-Kp) collected from human carriers, the human-polluted (hp)-environment, and food: (i) to compare the antimicrobial resistance …
View article: Conjugation of Polycationic Peptides Extends the Efficacy Spectrum of β‐Lactam Antibiotics
Conjugation of Polycationic Peptides Extends the Efficacy Spectrum of β‐Lactam Antibiotics Open
Antibiotic‐resistant enterococci represent a significant global health challenge. Unfortunately, most β‐lactam antibiotics are not applicable for enterococcal infections due to intrinsic resistance. To extend their antimicrobial spectrum, …
Optimization of the Diagnosis of Central Nervous System Infections in Vietnamese Hospitals: Results From a Retrospective Multicenter Study Open
Introduction Central nervous system infections pose significant health challenges, particularly in low- and middle-income countries, because of high morbidity and mortality rates. Rapid and accurate diagnosis is essential for effective tre…
OXA-48-like carbapenemases in <i>Proteus mirabilis</i> – novel genetic environments and a challenge for detection Open
OXA-48-like enzymes represent the most frequently detected carbapenemases in Enterobacterales in Western Europe, North Africa and the Middle East. In contrast to other species, the presence of OXA-48-like in Proteus mirabilis leads to an u…
View article: Epidemiological trends and susceptibility patterns of bloodstream infections caused by Enterococcus spp. in six German university hospitals – a prospectively evaluated multicentre cohort study from 2016-2020 of the R-Net study group
Epidemiological trends and susceptibility patterns of bloodstream infections caused by Enterococcus spp. in six German university hospitals – a prospectively evaluated multicentre cohort study from 2016-2020 of the R-Net study group Open
Objectives To analyse recent epidemiological trends of bloodstream infections (BSI) caused by Enterococcus spp. In adult patients admitted to tertiary care centres in Germany. Methods Epidemiological data from the multicentre R-NET study w…
Prognostic Value of Gut Microbiome for Conversion from Mild Cognitive Impairment to Alzheimer’s Disease Dementia within 4 Years: Results from the AlzBiom Study Open
Alterations in the gut microbiome are associated with the pathogenesis of Alzheimer’s disease (AD) and can be used as a diagnostic measure. However, longitudinal data of the gut microbiome and knowledge about its prognostic significance fo…
Forecasting local hospital bed demand for COVID-19 using on-request simulations Open
Accurate forecasting of hospital bed demand is crucial during infectious disease epidemics to avoid overwhelming healthcare facilities. To address this, we developed an intuitive online tool for individual hospitals to forecast COVID-19 be…
View article: Viral Genome Sequencing to Decipher In-Hospital SARS-CoV-2 Transmission Events
Viral Genome Sequencing to Decipher In-Hospital SARS-CoV-2 Transmission Events Open
Background: The SARS-CoV-2 pandemic has highlighted the need to better define in-hospital transmissions, a need that extends to all other common infectious diseases encountered in clinical settings. Objectives: To evaluate how whole viral …
Association of ward-level antibiotic consumption with healthcare-associated <i>Clostridioides difficile</i> infections: an ecological study in five German university hospitals, 2017–2019 Open
Objectives To analyse the influence of antibiotic consumption on healthcare-associated healthcare onset (HAHO) Clostridioides difficile infection (CDI) in a German university hospital setting. Methods Monthly ward-level antibiotic consumpt…
View article: Purine nucleotide limitation undermines antibiotic action in clinical<i>Escherichia coli</i>
Purine nucleotide limitation undermines antibiotic action in clinical<i>Escherichia coli</i> Open
Metabolic variation across pathogenic bacterial strains can impact their susceptibility to antibiotics 1–4 and promote evolution of antimicrobial resistance (AMR) 5,6 . However, little is known about which metabolic pathways contribute to …
High incidence of carbapenemase-producing<i>Pseudomonas aeruginosa</i>clinical isolates from Lagos, Nigeria Open
Background Carbapenem-resistant Pseudomonas aeruginosa strains are on the rise worldwide. This study characterized clinical isolates of P. aeruginosa from three Nigerian hospitals for carbapenem resistance. Methods Strains isolated from wo…
View article: Surveillance and Genomic Analysis of Third-Generation Cephalosporin-Resistant and Carbapenem-Resistant Klebsiella pneumoniae Complex in Germany
Surveillance and Genomic Analysis of Third-Generation Cephalosporin-Resistant and Carbapenem-Resistant Klebsiella pneumoniae Complex in Germany Open
To analyse the epidemiology and population structure of third-generation cephalosporin-resistant (3GCR) and carbapenem-resistant (CR) Klebsiella pneumoniae complex isolates, patients were screened for rectal colonisation with 3GCR/CR K. pn…
Resolving colistin resistance and heteroresistance in Enterobacter species Open
Enterobacter cloacae complex (ECC) represent globally important nosocomial pathogens. A three-year study of ECC in Germany identified Enterobacter xiangfangensis as the most common species (65.5%) detected, a result replicated by examining…
Evaluation of a laboratory-based high-throughput SARS-CoV-2 antigen assay Open
Objectives Antigen tests are an essential part of SARS-CoV-2 testing strategies. Rapid antigen tests are easy to use but less sensitive compared to nucleic acid amplification tests (NAT) and less suitable for large-scale testing. In contra…
View article: High prevalence of Pseudomonas aeruginosa carriage in residents of French and German long-term care facilities
High prevalence of Pseudomonas aeruginosa carriage in residents of French and German long-term care facilities Open
We found an unexpected high prevalence of PA intestinal carriage in LTCF residents mainly associated with individual-level factors. Our study revealed a polyclonal PA population structure suggesting that individual acquisition is more freq…
Signature of Alzheimer’s Disease in Intestinal Microbiome: Results From the AlzBiom Study Open
Background Changes in intestinal microbiome composition have been described in animal models of Alzheimer’s disease (AD) and AD patients. Here we investigated how well taxonomic and functional intestinal microbiome data and their combinati…