Samuel Sindié Sermé
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View article: Application of a high-resolution melt assay for monitoring SARS-CoV-2 variants in Burkina Faso and Kenya
Application of a high-resolution melt assay for monitoring SARS-CoV-2 variants in Burkina Faso and Kenya Open
The rapid emergence and global dissemination of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) highlighted a need for robust, adaptable surveillance systems. However, financial and infrastructure requirements for whole-genome…
View article: Single-cell transcriptomics reveals inter-ethnic variation in immune response to Falciparum malaria
Single-cell transcriptomics reveals inter-ethnic variation in immune response to Falciparum malaria Open
View article: Host-Derived Linoleic Acid Promotes Malaria Pathogenesis by Enhancing Plasmodium Falciparum Proliferation
Host-Derived Linoleic Acid Promotes Malaria Pathogenesis by Enhancing Plasmodium Falciparum Proliferation Open
View article: Artemether-Lumefantrine Versus Pyronaridine-Artesunate for the Treatment of Malaria in Patients with Mild to Moderate COVID-19 in Kenya and Burkina Faso: A Randomised Open-Label Trial (MALCOV)
Artemether-Lumefantrine Versus Pyronaridine-Artesunate for the Treatment of Malaria in Patients with Mild to Moderate COVID-19 in Kenya and Burkina Faso: A Randomised Open-Label Trial (MALCOV) Open
View article: The impact of interethnic lipidomic variation in falciparum malaria
The impact of interethnic lipidomic variation in falciparum malaria Open
View article: Correction: Assessment of the transmission blocking activity of antimalarial compounds by membrane feeding assays using natural Plasmodium falciparum gametocyte isolates from West-Africa
Correction: Assessment of the transmission blocking activity of antimalarial compounds by membrane feeding assays using natural Plasmodium falciparum gametocyte isolates from West-Africa Open
[This corrects the article DOI: 10.1371/journal.pone.0284751.].
View article: Effect of weekly fever-screening and treatment and monthly RDT testing and treatment on the infectious reservoir of malaria parasites in Burkina Faso: a cluster-randomised trial
Effect of weekly fever-screening and treatment and monthly RDT testing and treatment on the infectious reservoir of malaria parasites in Burkina Faso: a cluster-randomised trial Open
Bill & Melinda Gates Foundation, European Research Council, and The Netherlands Organization for Scientific Research.
View article: Application of a High-Resolution Melt Assay for Monitoring SARS-CoV-2 Variants in Burkina Faso and Kenya
Application of a High-Resolution Melt Assay for Monitoring SARS-CoV-2 Variants in Burkina Faso and Kenya Open
The rapid emergence and global dissemination of SARS-CoV-2 highlighted a need for robust, adaptable surveillance systems. However, financial and infrastructure requirements for whole genome sequencing (WGS) mean most surveillance data have…
View article: PA-658 Shigella incidence and resistance to commonly used antibiotics in children under five years of age living in a community setting in Ouagadougou, Burkina Faso
PA-658 Shigella incidence and resistance to commonly used antibiotics in children under five years of age living in a community setting in Ouagadougou, Burkina Faso Open
Background Shigellosis is a major public health problem worldwide. There is no vaccine to control shigellosis, which is the best way to control infectious diseases. To assess the true burden of shigellosis before proceeding with the evalua…
View article: Contribution of the Rapid LAMP-Based Diagnostic Test (RLDT) to the Evaluation of Enterotoxigenic Escherichia coli (ETEC) and Shigella in Childhood Diarrhea in the Peri-Urban Area of Ouagadougou, Burkina Faso
Contribution of the Rapid LAMP-Based Diagnostic Test (RLDT) to the Evaluation of Enterotoxigenic Escherichia coli (ETEC) and Shigella in Childhood Diarrhea in the Peri-Urban Area of Ouagadougou, Burkina Faso Open
The estimates of enterotoxigenic Escherichia coli (ETEC) and Shigella burden in developing countries are limited by the lack of rapid, accessible, and sensitive diagnostics and surveillance tools. We used a “Rapid LAMP based Diagnostic Tes…
View article: Assessment of the transmission blocking activity of antimalarial compounds by membrane feeding assays using natural Plasmodium falciparum gametocyte isolates from West-Africa
Assessment of the transmission blocking activity of antimalarial compounds by membrane feeding assays using natural Plasmodium falciparum gametocyte isolates from West-Africa Open
Antimalarial drugs that can block the transmission of Plasmodium gametocytes to mosquito vectors would be highly beneficial for malaria elimination efforts. Identifying transmission-blocking drugs currently relies on evaluation of their ac…
View article: Impact of Plasmodium falciparum infection on DNA methylation of circulating immune cells
Impact of Plasmodium falciparum infection on DNA methylation of circulating immune cells Open
The regulation of immune cell responses to infection is a complex process that involves various molecular mechanisms, including epigenetic regulation. DNA methylation has been shown to play central roles in regulating gene expression and m…
View article: Phased Multi-Country Seroepidemiology Study of Over 20000 Individuals In West Africa Reveals the Dynamics of SARS-CoV-2 Exposure Driven by Delta, Omicron and Omicron Waves
Phased Multi-Country Seroepidemiology Study of Over 20000 Individuals In West Africa Reveals the Dynamics of SARS-CoV-2 Exposure Driven by Delta, Omicron and Omicron Waves Open
View article: Active Screening and Treatment Significantly Reduces the Infectious Reservoir of Malaria in Burkina Faso: Results from a Randomised Trial
Active Screening and Treatment Significantly Reduces the Infectious Reservoir of Malaria in Burkina Faso: Results from a Randomised Trial Open
View article: Beta-Lactamase-Producing Genes and Integrons in <i>Escherichia coli</i> from Diarrheal Children in Ouagadougou, Burkina Faso
Beta-Lactamase-Producing Genes and Integrons in <i>Escherichia coli</i> from Diarrheal Children in Ouagadougou, Burkina Faso Open
This study aimed to determine the resistance of diarrheagenic Escherichia coli (DEC) strains to β-lactams antibiotics and to perform the molecular characterization of extended-spectrum β-lactamases (ESBLs) and integrons genes. It was carri…
View article: Molecular Characterization of β-Lactamase Producing Genes and Integrons in Diarrheagenic Escherichia Coli From Diarrheal Children Less Than Five Years of Age in Ouagadougou, Burkina Faso.
Molecular Characterization of β-Lactamase Producing Genes and Integrons in Diarrheagenic Escherichia Coli From Diarrheal Children Less Than Five Years of Age in Ouagadougou, Burkina Faso. Open
Background The aim of this study was to determine the resistance of diarrheagenic Escherichia coli strains to β-lactams antibiotics and to perform the molecular characterization of Extended Spectrum β-lactamases (ESBL) and integrons genes.…
View article: Higher gametocyte production and mosquito infectivity in chronic compared to incident Plasmodium falciparum infections
Higher gametocyte production and mosquito infectivity in chronic compared to incident Plasmodium falciparum infections Open
View article: Integrative genomic analysis reveals mechanisms of immune evasion in P. falciparum malaria
Integrative genomic analysis reveals mechanisms of immune evasion in P. falciparum malaria Open
View article: Increased gametocyte production and mosquito infectivity in chronic versus incident <i>Plasmodium falciparum</i> infections
Increased gametocyte production and mosquito infectivity in chronic versus incident <i>Plasmodium falciparum</i> infections Open
We longitudinally assessed P. falciparum parasite kinetics, gametocyte production and infectivity in incident infections that were naturally acquired following infection clearance and in chronic asymptomatic infections in Burkina Faso. 92%…
View article: Distribution of msp1, msp2 and eba175 Allelic Family According to Hemoglobin Genotype and G6PD Type from Children with Uncomplicated Malaria in Banfora Heath District (Burkina Faso)
Distribution of msp1, msp2 and eba175 Allelic Family According to Hemoglobin Genotype and G6PD Type from Children with Uncomplicated Malaria in Banfora Heath District (Burkina Faso) Open
Aim: The present study aimed to evaluate the Plasmodium falciparum genetic diversity according to the host hemoglobin and G6PD genetic variants during the course of malaria in infected children aged from 2 to 10 years and living in endemic…
View article: Experimental Study: The Relationship between Plasmodium falciparum Gametocyte Carriage and Mosquitoes Infectiousness in Two Sympatric Ethnic Groups in Burkina Faso
Experimental Study: The Relationship between Plasmodium falciparum Gametocyte Carriage and Mosquitoes Infectiousness in Two Sympatric Ethnic Groups in Burkina Faso Open
Aims: The lower susceptibility of the Fulani to malaria compared to Mossi was previously described in Burkina Faso in West Africa. The mature gametocyte stage of Plasmodium falciparum is known to be the only stage capable of infecting the …
View article: Prevalence of Plasmodium falciparum Chloroquine Resistance Transporter (Pfcrt76T) Mutation Associated with Antimalarial Drug Resistance in Two Different Epidemiological Setting (Banfora and Saponé) in Burkina Faso Few Years after the Implementation of Artemisnine Based Combination Therapy (ACTs)
Prevalence of Plasmodium falciparum Chloroquine Resistance Transporter (Pfcrt76T) Mutation Associated with Antimalarial Drug Resistance in Two Different Epidemiological Setting (Banfora and Saponé) in Burkina Faso Few Years after the Implementation of Artemisnine Based Combination Therapy (ACTs) Open
Introduction: In spite of considerable progress, malaria remains a public health problem in many areas, particularly in sub-Saharan Africa. One major complexity of malaria disease is caused by the development and the spread of vector and p…
View article: Abnormalities of Hemoglobin and Glucose-6-Phosphate-Dehydrogenase Deficiency in Children with Uncomplicated Malaria and Living in Banfora and Saponé, Two Different Malaria Setting of Burkina Faso
Abnormalities of Hemoglobin and Glucose-6-Phosphate-Dehydrogenase Deficiency in Children with Uncomplicated Malaria and Living in Banfora and Saponé, Two Different Malaria Setting of Burkina Faso Open
Aims: The aim of this study is to assess the prevalence of hemoglobin abnormalities and G6PD deficiency and their respective influence on anemia occurring in less than five years old children with clinical P. falciparum malaria living in B…
View article: The Impact of Human Genetic Factors (G6pd and Type of Hemoglobin) on the Course of Uncomplicated Malaria Infection in Children Aged from 2 to 10 Years Living in the Banfora Health District in Burkina Faso
The Impact of Human Genetic Factors (G6pd and Type of Hemoglobin) on the Course of Uncomplicated Malaria Infection in Children Aged from 2 to 10 Years Living in the Banfora Health District in Burkina Faso Open
Aims: The aim of this study was to assess the impact of hemoglobin polymorphisms and G6PD deficiency on the course of uncomplicated malaria infection in children aged from 2 to 10 years in Burkina Faso.
Study Design: The study was conduct…
View article: Biology of Plasmodium falciparum gametocyte sex ratio and implications in malaria parasite transmission
Biology of Plasmodium falciparum gametocyte sex ratio and implications in malaria parasite transmission Open
View article: Variation in natural exposure to anopheles mosquitoes and its effects on malaria transmission
Variation in natural exposure to anopheles mosquitoes and its effects on malaria transmission Open
Variation in biting frequency by Anopheles mosquitoes can explain some of the heterogeneity in malaria transmission in endemic areas. In this study in Burkina Faso, we assessed natural exposure to mosquitoes by matching the genotype of blo…
View article: Author response: Variation in natural exposure to anopheles mosquitoes and its effects on malaria transmission
Author response: Variation in natural exposure to anopheles mosquitoes and its effects on malaria transmission Open
View article: Molecular characterization of diarrheagenic Escherichia coli in children less than 5 years of age with diarrhea in Ouagadougou, Burkina Faso
Molecular characterization of diarrheagenic Escherichia coli in children less than 5 years of age with diarrhea in Ouagadougou, Burkina Faso Open
Diarrheagenic Escherichia coli (DEC) is important bacteria of children’s endemic and epidemic diarrhea worldwide. The aim of this study was to determine the prevalence of DEC isolated from stool samples collected from children with acute d…
View article: Clinical Variation of<i>Plasmodium falciparum eba-175</i>,<i>ama-1</i>, and<i>msp-3</i>Genotypes in Young Children Living in a Seasonally High Malaria Transmission Setting in Burkina Faso
Clinical Variation of<i>Plasmodium falciparum eba-175</i>,<i>ama-1</i>, and<i>msp-3</i>Genotypes in Young Children Living in a Seasonally High Malaria Transmission Setting in Burkina Faso Open
The association between P. falciparum eba-175 , ama-1 , and msp-3 polymorphism in the pathogenicity of malaria disease was investigated. We therefore compared the prevalence of different alleles between symptomatic and asymptomatic malaria…