Sébastien Tremblay
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View article: Initial validation of SENIC: a cognitive test for assessing concussion in team sports
Initial validation of SENIC: a cognitive test for assessing concussion in team sports Open
Our study proposes an innovative neurocognitive assessment approach that combines external validity with dynamic cognition. SENIC seems promising in providing a contextually relevant evaluation of cognitive functioning in athletes at risk …
View article: SIV infection induces alterations in gene expression and loss of interneurons in Rhesus Macaque frontal cortex during early systemic infection
SIV infection induces alterations in gene expression and loss of interneurons in Rhesus Macaque frontal cortex during early systemic infection Open
View article: A single-cell multi-omic atlas spanning the adult rhesus macaque brain
A single-cell multi-omic atlas spanning the adult rhesus macaque brain Open
Cataloging the diverse cellular architecture of the primate brain is crucial for understanding cognition, behavior, and disease in humans. Here, we generated a brain-wide single-cell multimodal molecular atlas of the rhesus macaque brain. …
View article: Human OPRM1 and murine Oprm1 promoter driven viral constructs for genetic access to μ-opioidergic cell types
Human OPRM1 and murine Oprm1 promoter driven viral constructs for genetic access to μ-opioidergic cell types Open
View article: Neural signatures of natural behavior in socializing macaques
Neural signatures of natural behavior in socializing macaques Open
Our understanding of the neurobiology of primate behavior largely derives from artificial tasks in highly-controlled laboratory settings, overlooking most natural behaviors primate brains evolved to produce 1–3 . In particular, how primate…
View article: Multiregion transcriptomic profiling of the primate brain reveals signatures of aging and the social environment
Multiregion transcriptomic profiling of the primate brain reveals signatures of aging and the social environment Open
View article: A single-cell multi-omic atlas spanning the adult rhesus macaque brain
A single-cell multi-omic atlas spanning the adult rhesus macaque brain Open
Cataloging the diverse cellular architecture of the primate brain is crucial for understanding cognition, behavior and disease in humans. Here, we generated a brain-wide single-cell multimodal molecular atlas of the rhesus macaque brain. A…
View article: Epiphenomenal neural activity in the primate cortex
Epiphenomenal neural activity in the primate cortex Open
When neuroscientists record neural activity from the brain, they often conclude that neural responses observed during task performance are indicative of the functional role of the brain area(s) studied. In humans and nonhuman primates, it …
View article: Neural cognitive signals during spontaneous movements in the macaque
Neural cognitive signals during spontaneous movements in the macaque Open
The single neuron basis of cognitive processing in primates has mostly been studied in laboratory settings where movements are severely restricted. It is unclear, therefore, how natural movements might affect neural signatures of cognition…
View article: Viral Strategies for Targeting and Manipulating Opioidergic Neuronal Populations for Cell Specific Study and Therapeutic Intervention
Viral Strategies for Targeting and Manipulating Opioidergic Neuronal Populations for Cell Specific Study and Therapeutic Intervention Open
View article: From the field to the lab and back: neuroethology of primate social behavior
From the field to the lab and back: neuroethology of primate social behavior Open
View article: An Open Resource for Non-human Primate Optogenetics
An Open Resource for Non-human Primate Optogenetics Open
View article: The Effects of Methylphenidate (Ritalin) on the Neurophysiology of the Monkey Caudal Prefrontal Cortex
The Effects of Methylphenidate (Ritalin) on the Neurophysiology of the Monkey Caudal Prefrontal Cortex Open
Methylphenidate (MPH), commonly known as Ritalin, is the most widely prescribed drug worldwide to treat patients with attention deficit disorders. Although MPH is thought to modulate catecholamine neurotransmission in the brain, it remains…
View article: Mild traumatic brain injury: The effect of age at trauma onset on brain structure integrity
Mild traumatic brain injury: The effect of age at trauma onset on brain structure integrity Open
Mounting evidence suggests that mild traumatic brain injuries (mTBI) have long-term effects that interact with the aging process to precipitate cognitive decline. This line of research predicts that early exposure to brain trauma is partic…
View article: Defining a multimodal signature of remote sports concussions
Defining a multimodal signature of remote sports concussions Open
Sports‐related concussions lead to persistent anomalies of the brain structure and function that interact with the effects of normal ageing. Although post‐mortem investigations have proposed a bio‐signature of remote concussions, there is …
View article: Social Decision-Making and the Brain: A Comparative Perspective
Social Decision-Making and the Brain: A Comparative Perspective Open
View article: Effects of neural ensemble size and composition on the decoding of attention in primate lateral prefrontal cortex
Effects of neural ensemble size and composition on the decoding of attention in primate lateral prefrontal cortex Open
The allocation of attention can be decoded from the activity of lateral prefrontal cortex neuronal ensembles (Tremblay et al., 2015). One issue that remains unclear is the impact of a neural population's size and composition on decoding of…
View article: Correlation between the effects of attention and response normalization in prefrontal area 8A neurons is cell type dependent.
Correlation between the effects of attention and response normalization in prefrontal area 8A neurons is cell type dependent. Open
Many visual neurons lower their response rates to a stimulus in the receptive field when other stimuli are added inside or outside their receptive field. This phenomenon has been proposed to be the result of a canonical normalization mecha…
View article: Single trial decoding of visual attention from local field potentials in the primate lateral prefrontal cortex
Single trial decoding of visual attention from local field potentials in the primate lateral prefrontal cortex Open
It has recently been shown that attention can be decoded from the spiking activity of ensembles of neurons in area 8A of the monkey lateral prefrontal cortex (Tremblay et al., 2015). As spikes are believed to reflect the output of a given …
View article: Single-Trial Decoding of Visual Attention from Local Field Potentials in the Primate Lateral Prefrontal Cortex Is Frequency-Dependent
Single-Trial Decoding of Visual Attention from Local Field Potentials in the Primate Lateral Prefrontal Cortex Is Frequency-Dependent Open
Local field potentials (LFPs) are fluctuations of extracellular voltage that may reflect the physiological phenomena occurring within a volume of neural tissue. It is known that the allocation of spatial attention modulates the amplitude o…