Samuel W. Cramer
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View article: Improving neurological deficits secondary to transverse myelitis using epidural spinal cord stimulation: illustrative cases
Improving neurological deficits secondary to transverse myelitis using epidural spinal cord stimulation: illustrative cases Open
BACKGROUND Epidural spinal cord stimulation (eSCS) is canonically used for the treatment of intractable, chronic pain. Recent efforts have successfully utilized eSCS to improve neurological deficits in patients with spinal cord injury. How…
View article: Diagnostic predictive values for sport-related concussions: a systematic review and diagnostic meta-analysis
Diagnostic predictive values for sport-related concussions: a systematic review and diagnostic meta-analysis Open
OBJECTIVE Sport-related concussions (SRCs) can cause significant neurological symptoms, and approximately 10%–15% of athletes with SRC experience a prolonged recovery. Given the lack of visible injury on brain imaging and their varied pres…
View article: Clinical Benefit of Vagus Nerve Stimulation for Epilepsy: Assessment of Randomized Controlled Trials and Prospective Non-Randomized Studies
Clinical Benefit of Vagus Nerve Stimulation for Epilepsy: Assessment of Randomized Controlled Trials and Prospective Non-Randomized Studies Open
We examined the efficacy of vagal nerve stimulation (VNS) for patients suffering from medically intractable epilepsy. Four randomized controlled trials (RCTs - 3 adult RCTs and 1 pediatric RCT) were identified in our comprehensive literatu…
View article: Wide-field calcium imaging reveals widespread changes in cortical functional connectivity following mild traumatic brain injury in the mouse
Wide-field calcium imaging reveals widespread changes in cortical functional connectivity following mild traumatic brain injury in the mouse Open
>2.5 million individuals in the United States suffer mild traumatic brain injuries (mTBI) annually. Mild TBI is characterized by a brief period of altered consciousness, without objective findings of anatomic injury on clinical imaging or …
View article: Rates of operative intervention for infection after synthetic or autologous cranioplasty: a National Readmissions Database analysis
Rates of operative intervention for infection after synthetic or autologous cranioplasty: a National Readmissions Database analysis Open
OBJECTIVE The aim of this study was to characterize the clinical utilization and associated charges of autologous bone flap (ABF) versus synthetic flap (SF) cranioplasty and to characterize the postoperative infection risk of SF versus ABF…
View article: Mapping spreading depolarisations after traumatic brain injury: a pilot clinical study protocol
Mapping spreading depolarisations after traumatic brain injury: a pilot clinical study protocol Open
Introduction Cortical spreading depolarisation (CSD) is characterised by a near-complete loss of the ionic membrane potential of cortical neurons and glia propagating across the cerebral cortex, which generates a transient suppression of s…
View article: Persistent Racial Disparities in Deep Brain Stimulation for Parkinson's Disease
Persistent Racial Disparities in Deep Brain Stimulation for Parkinson's Disease Open
We sought to determine whether racial and socioeconomic disparities in the utilization of deep brain stimulation (DBS) for Parkinson's disease (PD) have improved over time. We examined DBS utilization and analyzed factors associated with p…
View article: Persistent racial disparities in deep brain stimulation for Parkinson’s disease
Persistent racial disparities in deep brain stimulation for Parkinson’s disease Open
We sought to determine whether racial and socio-economic disparities in the utilization of deep brain stimulation (DBS) for Parkinson’s disease (PD) have improved over time. We examined DBS utilization and analyzed factors associated with …
View article: Resection of disseminated recurrent myxopapillary ependymoma with more than 4-year follow-up: operative nuance for prolonged prone position. Illustrative case
Resection of disseminated recurrent myxopapillary ependymoma with more than 4-year follow-up: operative nuance for prolonged prone position. Illustrative case Open
BACKGROUND Symptomatic disseminated myxopapillary ependymoma (MPE) in a young person presents a daunting challenge because the risks of prolonged prone positioning and spinal cord injury may outweigh the likelihood of attaining the benefit…
View article: Wide-field Calcium Imaging Reveals Widespread Changes in Cortical Connectivity Following Repetitive, Mild Traumatic Brain Injury in the Mouse
Wide-field Calcium Imaging Reveals Widespread Changes in Cortical Connectivity Following Repetitive, Mild Traumatic Brain Injury in the Mouse Open
The physiologic basis underlying the long-term consequences of repetitive, mild traumatic brain injury (mTBI) remains poorly understood. Mild traumatic brain injury often results in brief loss of consciousness, impaired attention and conce…
View article: Through the looking glass: A review of cranial window technology for optical access to the brain
Through the looking glass: A review of cranial window technology for optical access to the brain Open
View article: Injuries from Less-Lethal Weapons during the George Floyd Protests in Minneapolis
Injuries from Less-Lethal Weapons during the George Floyd Protests in Minneapolis Open
Injuries from Less-lethal Weapons during the George Floyd Protests In this analysis involving patients treated in Minnesota during protests after George Floyd’s death, 89 patients were identified w...
View article: PATH-02. CHARACTERIZATION OF FUNCTIONAL NETWORK EFFECTS IN THE CEREBRAL CORTEX DURING BRAIN TUMORIGENESIS IN THE MOUSE
PATH-02. CHARACTERIZATION OF FUNCTIONAL NETWORK EFFECTS IN THE CEREBRAL CORTEX DURING BRAIN TUMORIGENESIS IN THE MOUSE Open
INTRODUCTION Neuro-cognitive decline is near universal in glioblastoma patients and negatively impacts the quality of life for afflicted patients. Yet, there is little information on longitudinal effects of brain tumor growth on cerebral c…
View article: TMOD-10. EFFECT OF BRAIN TUMORIGENESIS ON CEREBRAL CORTICAL FUNCTIONAL CONNECTIVITY IN THE MOUSE
TMOD-10. EFFECT OF BRAIN TUMORIGENESIS ON CEREBRAL CORTICAL FUNCTIONAL CONNECTIVITY IN THE MOUSE Open
INTRODUCTION Neuro-cognitive decline is near universal in glioblastoma patients and negatively impacts the quality of life for afflicted patients. Yet, there is little information on longitudinal effects of brain tumor growth on cerebral c…
View article: Photodynamic Therapy for the Treatment of Glioblastoma
Photodynamic Therapy for the Treatment of Glioblastoma Open
Glioblastoma is the most common form of adult brain cancer and remains one of the deadliest of human cancers. The current standard-of-care involves maximal tumor resection followed by treatment with concurrent radiation therapy and the che…
View article: Abnormal Excitability and Episodic Low-Frequency Oscillations in the Cerebral Cortex of the<i>tottering</i>Mouse
Abnormal Excitability and Episodic Low-Frequency Oscillations in the Cerebral Cortex of the<i>tottering</i>Mouse Open
The Ca 2+ channelopathies caused by mutations of the CACNA1A gene that encodes the pore-forming subunit of the human Ca v 2.1 (P/Q-type) voltage-gated Ca 2+ channel include episodic ataxia type 2 (EA2). Although, in EA2 the emphasis has be…