Samuel W. Fung
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View article: Metaplastic priming enables non-ionotropic NMDA receptor-mediated synaptic depotentiation in the hippocampus
Metaplastic priming enables non-ionotropic NMDA receptor-mediated synaptic depotentiation in the hippocampus Open
The reversal of learning-induced synaptic potentiation through depotentiation is thought to underlie forgetting and can be influenced by prior synaptic activity. Here, we evaluated how such metaplastic alterations manifest at the synaptic …
View article: Chronic pain mediated changes in the appetitive value of affective gentle touch in mice
Chronic pain mediated changes in the appetitive value of affective gentle touch in mice Open
The existence of skin-to-brain circuits for rewarding gentle touch highlight its critical nature across species. However, this gentle affective touch is not always appetitive and can produce aversion or negative affect in disorders such as…
View article: Nociceptor activity induces nonionotropic NMDA receptor signaling to enable spinal reconsolidation and reverse pathological pain
Nociceptor activity induces nonionotropic NMDA receptor signaling to enable spinal reconsolidation and reverse pathological pain Open
Chronic, pathological pain is a highly debilitating condition that can arise and be maintained through central sensitization. Central sensitization shares mechanistic and phenotypic parallels with memory formation. In a sensory model of me…
View article: SOX2 Regulates Neuronal Differentiation of the Suprachiasmatic Nucleus
SOX2 Regulates Neuronal Differentiation of the Suprachiasmatic Nucleus Open
In mammals, the hypothalamic suprachiasmatic nucleus (SCN) functions as the central circadian pacemaker, orchestrating behavioral and physiological rhythms in alignment to the environmental light/dark cycle. The neurons that comprise the S…
View article: Sox2 Ablation in the Suprachiasmatic Nucleus Perturbs Anxiety- and Depressive-like Behaviors
Sox2 Ablation in the Suprachiasmatic Nucleus Perturbs Anxiety- and Depressive-like Behaviors Open
Mood disorders negatively impact the lives of hundreds of millions of individuals worldwide every year, yet the precise molecular mechanisms by which they manifest remain elusive. Circadian dysregulation is one avenue by which mood disorde…
View article: Spinal reconsolidation engages non-ionotropic NMDA receptor signaling to reverse pain hypersensitivity
Spinal reconsolidation engages non-ionotropic NMDA receptor signaling to reverse pain hypersensitivity Open
Reconsolidation enables the activity-dependent modification of memory traces and has been used to reverse addiction, fear memory, and pain hypersensitivity in animal models. We demonstrate that non-ionotropic NMDA receptor signalling in th…
View article: Insights Into Spinal Dorsal Horn Circuit Function and Dysfunction Using Optical Approaches
Insights Into Spinal Dorsal Horn Circuit Function and Dysfunction Using Optical Approaches Open
Somatosensation encompasses a variety of essential modalities including touch, pressure, proprioception, temperature, pain, and itch. These peripheral sensations are crucial for all types of behaviors, ranging from social interaction to da…
View article: SOX2-Dependent Transcription in Clock Neurons Promotes the Robustness of the Central Circadian Pacemaker
SOX2-Dependent Transcription in Clock Neurons Promotes the Robustness of the Central Circadian Pacemaker Open
Summary: Clock neurons within the mammalian suprachiasmatic nuclei (SCN) encode circadian time using interlocked transcription-translation feedback loops (TTFLs) that drive rhythmic gene expression. However, the contributions of other tran…