Samuel A. Woodle
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View article: Sources of bias and limitations of thrombinography: inner filter effect and substrate depletion at the edge of failure algorithm
Sources of bias and limitations of thrombinography: inner filter effect and substrate depletion at the edge of failure algorithm Open
Background Fluorogenic thrombin generation (TG) is a global hemostasis assay that provides an overall representation of hemostasis potential. However, the accurate detection of thrombin activity in plasma may be affected by artifacts inher…
View article: Optimization of the thrombin generation test components to measure potency of factor VIII concentrates
Optimization of the thrombin generation test components to measure potency of factor VIII concentrates Open
Introduction The thrombin generation test (TGT) is used both as a global haemostasis assay, and to compare activities of coagulation factor concentrates that have been spiked into patient plasma. However, TGT has not been systematically op…
View article: Characterization of procoagulant extracellular vesicles and platelet membrane disintegration in DMSO‐cryopreserved platelets
Characterization of procoagulant extracellular vesicles and platelet membrane disintegration in DMSO‐cryopreserved platelets Open
Background Freezing is promising for extended platelet (PLT) storage for transfusion. 6% DMSO cryopreserved PLTs (CPPs) are currently in clinical development. CPPs contain significant amount of platelet membrane vesicles (PMVs). PLT‐membra…