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View article: Supplementary Figure S4 from Early Detection of Malignant and Premalignant Peripheral Nerve Tumors Using Cell-Free DNA Fragmentomics
Supplementary Figure S4 from Early Detection of Malignant and Premalignant Peripheral Nerve Tumors Using Cell-Free DNA Fragmentomics Open
Supplemental Figure 4. 4-mer end motifs across F-profiles. Comprehensive view of the distribution and prevalence of each possible 4-mer end motif within each of the six distinct F-profiles derived from non-negative matrix factorization (NM…
View article: Supplementary Figure S3 from Early Detection of Malignant and Premalignant Peripheral Nerve Tumors Using Cell-Free DNA Fragmentomics
Supplementary Figure S3 from Early Detection of Malignant and Premalignant Peripheral Nerve Tumors Using Cell-Free DNA Fragmentomics Open
Supplemental Figure 3. Number of NMF components versus AUC. Performance (AUC) of NMF models in OVO comparisons is plotted against the number n components (Methods) used. The number of components approaches the AUC’s asymptote in each OVO a…
View article: Supplementary Figure S2 from Early Detection of Malignant and Premalignant Peripheral Nerve Tumors Using Cell-Free DNA Fragmentomics
Supplementary Figure S2 from Early Detection of Malignant and Premalignant Peripheral Nerve Tumors Using Cell-Free DNA Fragmentomics Open
Supplemental Figure 2. Diminishing improvements in accuracy with deeper sequencing. MPNST samples sequenced to ∼25x were downsampled in five iterations per goal coverage (Methods). Size selected, copy number derived tumor fraction variabil…
View article: Supplementary Figure S1 from Early Detection of Malignant and Premalignant Peripheral Nerve Tumors Using Cell-Free DNA Fragmentomics
Supplementary Figure S1 from Early Detection of Malignant and Premalignant Peripheral Nerve Tumors Using Cell-Free DNA Fragmentomics Open
Supplemental Figure 1. Attributes of atypical neurofibroma samples. Histologic characteristics and, when available, TSO500 clinical sequencing results for paired tissue corresponding with AN cell-free DNA.
View article: Data from Early Detection of Malignant and Premalignant Peripheral Nerve Tumors Using Cell-Free DNA Fragmentomics
Data from Early Detection of Malignant and Premalignant Peripheral Nerve Tumors Using Cell-Free DNA Fragmentomics Open
Purpose:Early detection of neurofibromatosis type 1 (NF1)–associated peripheral nerve sheath tumors (PNST) informs clinical decision-making, enabling early definitive treatment and potentially averting deadly outcomes. In this study, we de…
View article: Supplementary Tables S1-S3 from Early Detection of Malignant and Premalignant Peripheral Nerve Tumors Using Cell-Free DNA Fragmentomics
Supplementary Tables S1-S3 from Early Detection of Malignant and Premalignant Peripheral Nerve Tumors Using Cell-Free DNA Fragmentomics Open
Supplemental Table 1. Participant characteristics. Supplemental Table 2. MPNST patient characteristics. Supplemental Table 3. Details of all sequencing libraries in this study.
View article: Early Detection of Malignant and Premalignant Peripheral Nerve Tumors Using Cell-Free DNA Fragmentomics
Early Detection of Malignant and Premalignant Peripheral Nerve Tumors Using Cell-Free DNA Fragmentomics Open
Purpose: Early detection of neurofibromatosis type 1 (NF1)–associated peripheral nerve sheath tumors (PNST) informs clinical decision-making, enabling early definitive treatment and potentially averting deadly outcomes. In this study, we d…
View article: Challenges in determining the malignant potential of atypical neurofibromas (aNF) using histopathologic features and the potential need for <i>CDKN2A/2B</i> testing: a case report
Challenges in determining the malignant potential of atypical neurofibromas (aNF) using histopathologic features and the potential need for <i>CDKN2A/2B</i> testing: a case report Open
Atypical neurofibromas (aNF) are peripheral nerve sheath tumors (PNSTs) histologically defined by cytologic atypia, hypercellularity, loss of neurofibroma architecture, and/or increased mitotic activity. aNF often have a heterozygous loss …
View article: Early detection of malignant and pre-malignant peripheral nerve tumors using cell-free DNA fragmentomics
Early detection of malignant and pre-malignant peripheral nerve tumors using cell-free DNA fragmentomics Open
Early detection of neurofibromatosis type 1 (NF1) associated peripheral nerve sheath tumors (PNST) informs clinical decision-making, potentially averting deadly outcomes. Here, we describe a cell-free DNA (cfDNA) fragmentomic approach whic…
View article: COVID-19 severity and cardiovascular outcomes in SARS-CoV-2-infected patients with cancer and cardiovascular disease
COVID-19 severity and cardiovascular outcomes in SARS-CoV-2-infected patients with cancer and cardiovascular disease Open
Co-morbid CVD/CVRF is associated with higher COVID-19 severity among patients with cancer, particularly those not receiving active cancer therapy. While infrequent, COVID-19 related CV complications were higher in patients with comorbid CV…
View article: Association between Vitamin D, P1NP, and BMD as major indicators of bone health in local population of Pakistan
Association between Vitamin D, P1NP, and BMD as major indicators of bone health in local population of Pakistan Open
It is commonly known that the Pakistani population has inadequate vitamin D levels, but its effects on bone health and the level of N-terminal peptide of procollagen (PINP) have not yet determined. The aim of the research work was to check…
View article: Relationship between Vitamin D Insufficient, Vitamin D Deficient Pakistani population and COVID-19
Relationship between Vitamin D Insufficient, Vitamin D Deficient Pakistani population and COVID-19 Open
The people with less Vitamin D have enlarged probability for acute respiratory tract infections. There is substantial uncertainty about the link between “25(OH)D” ratio and the prevalence of “COVID-19”. With the major endpoints of death, d…
View article: Determinition of Bone Strength by Using Procollagen Type 1 N-Terminal Propeptide (P1NP) as a Predictive Marker in Native Population of Pakistan.
Determinition of Bone Strength by Using Procollagen Type 1 N-Terminal Propeptide (P1NP) as a Predictive Marker in Native Population of Pakistan. Open
Due to better health facilities, food and living facilities the life expectancy is increasing which is leading towards Osteopenia and Osteoporosis in the whole world. Despites of its prevalence it is ignored in Pakistan due to which it is …
View article: Physical Activity as an Element of Health Life Style among High School Children’s: an Analytical Approach
Physical Activity as an Element of Health Life Style among High School Children’s: an Analytical Approach Open
Physical inactivity is one of the most alarming health indicators in the world. Physical activity and fitness levels decline worldwide among children and adolescents. The use of electronic entertainment in Pakistan affects the activity lev…
View article: Leveraging corona virus disease 2019 vaccination to promote hepatitis C screening
Leveraging corona virus disease 2019 vaccination to promote hepatitis C screening Open
Health care initiatives, such as hepatitis C virus (HCV) screening, have been greatly overshadowed by the corona virus disease 2019 (COVID‐19) pandemic. However, COVID‐19 vaccination programs also provide an opportunity to engage with a hi…
View article: Urine eosinophil‐derived neurotoxin: A potential marker of activity in select eosinophilic disorders
Urine eosinophil‐derived neurotoxin: A potential marker of activity in select eosinophilic disorders Open
Background Biomarkers of eosinophilic disease activity, especially in the context of novel therapies that reduce blood eosinophil counts, are an unmet need. Absolute eosinophil count (AEC) does not accurately reflect tissue eosinophilia or…
View article: Advances enabled by a Regional Environmental Prediction system developed in the UK
Advances enabled by a Regional Environmental Prediction system developed in the UK Open
<div>In partnership with other UK institutions, the UK Met Office has developed a regional environmental prediction system at km scale, over two domains: the Northwest European shelf and the Indian region. This provides a flexible re…
View article: A comparative systematic scan of COVID-19 health literacy information sources for Canadian university students
A comparative systematic scan of COVID-19 health literacy information sources for Canadian university students Open
Introduction With the rapid spread of online coronavirus-related health information, it is important to ensure that this information is reliable and effectively communicated. This study observes the dissemination of COVID-19 health litera…
View article: Analyse comparative systématique des sources d’information sur la littératie en matière de santé liée à la COVID 19 des étudiants universitaires au Canada
Analyse comparative systématique des sources d’information sur la littératie en matière de santé liée à la COVID 19 des étudiants universitaires au Canada Open
Introduction Étant donné la diffusion rapide de l’information en ligne sur la santé liée au coronavirus, il est important de s’assurer que cette information est fiable et communiquée efficacement. Cette étude traite de la diffusion de l’i…
View article: Using Social Media as a Survey Recruitment Strategy for Post-Secondary Students During the COVID-19 Pandemic
Using Social Media as a Survey Recruitment Strategy for Post-Secondary Students During the COVID-19 Pandemic Open
The COVID-19 pandemic rapidly forced Canadian post-secondary students into remote learning methods, with potential implications on their academic success and health. In recent years, the use of social media to promote research participatio…
View article: Imagining a lean and agile digital health ecosystem – a measure of pandemic responsiveness
Imagining a lean and agile digital health ecosystem – a measure of pandemic responsiveness Open
View article: Impact of Age, Tumor Size, Lymph Node Metastasis, Stage, Receptor Status and Menopausal Status on Overall Survival of Breast Cancer Patients in Pakistan
Impact of Age, Tumor Size, Lymph Node Metastasis, Stage, Receptor Status and Menopausal Status on Overall Survival of Breast Cancer Patients in Pakistan Open
Tumor size, lymph node metastases, receptor status, her 2 neu positivity, skin involvement, and chest wall involvement have significant effects whereas age and menopausal status have no significant effect on overall survival of breast canc…