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View article: Risk of Sudden Death in Patients With RASopathy Hypertrophic Cardiomyopathy
Risk of Sudden Death in Patients With RASopathy Hypertrophic Cardiomyopathy Open
RAS-HCM was associated with a higher incidence of nonarrhythmic death or transplant but similar incidence of SCD as P-HCM. However, ICDs were used less frequently in RAS-HCM compared to P-HCM. In addition to monitoring for heart failure an…
View article: The Prevalence and Association of Exercise Test Abnormalities With Sudden Cardiac Death and Transplant-Free Survival in Childhood Hypertrophic Cardiomyopathy
The Prevalence and Association of Exercise Test Abnormalities With Sudden Cardiac Death and Transplant-Free Survival in Childhood Hypertrophic Cardiomyopathy Open
Background: Hypertrophic cardiomyopathy (HCM) can be associated with an abnormal exercise response. In adults with HCM, abnormal results on exercise stress testing are predictive of heart failure outcomes. Our goal was to determine whether…
View article: Genetic Diagnosis and the Severity of Cardiovascular Phenotype in Patients With Elastin Arteriopathy
Genetic Diagnosis and the Severity of Cardiovascular Phenotype in Patients With Elastin Arteriopathy Open
Background: Elastin insufficiency causes recurrent vascular stenoses. Hemizygous deletion of the elastin gene ( ELN ) causes Williams-Beuren syndrome (WBS), while single nucleotide variants in ELN cause nonsyndromic supravalvar aortic sten…
View article: Factors influencing health service utilization among the elderly in Insein Township, Yangon Region
Factors influencing health service utilization among the elderly in Insein Township, Yangon Region Open
Background: With the increasing needs of the aging population and the increasing prevalence of non-communicable diseases, assessment of the equity and accessibility of health care among the elderly has become important. Methods: A cross-se…
View article: Pediatric Outcomes in Transplant: PersOnaliSing Immunosuppression To ImproVe Efficacy (POSITIVE Study): The Collaboration and Design of a National Transplant Precision Medicine Program
Pediatric Outcomes in Transplant: PersOnaliSing Immunosuppression To ImproVe Efficacy (POSITIVE Study): The Collaboration and Design of a National Transplant Precision Medicine Program Open
Background Despite age-related differences in biology, physiology, and behavior, transplant immunosuppression is not tailored by age. This likely contributes to high graft failure and posttransplant complications. We present the aims, desi…
View article: A randomized clinical trial of age and genotype‐guided tacrolimus dosing after pediatric solid organ transplantation
A randomized clinical trial of age and genotype‐guided tacrolimus dosing after pediatric solid organ transplantation Open
Background Tacrolimus pharmacokinetics are influenced by age and CYP 3A5 genotype with CYP 3A5 expressors ( CYP 3A5*1/*1 or *1/*3 ) being fast metabolizers. However, the benefit of genotype‐guided dosing in pediatric solid organ transplant…