Sudhir Bolla
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View article: Mitochondrial dysfunction and impaired DNA damage repair through PICT1 dysregulation in alveolar type II cells in emphysema
Mitochondrial dysfunction and impaired DNA damage repair through PICT1 dysregulation in alveolar type II cells in emphysema Open
Background Alveolar type II (ATII) cells have a stem cell potential in the adult lung and repair the epithelium after injury induced by harmful factors. Their damage contributes to emphysema development, characterized by alveolar wall dest…
View article: Transthyretin Cardiac Amyloidosis: Insights into Wild-Type Variants and Familial Amyloid Cardiomyopathy
Transthyretin Cardiac Amyloidosis: Insights into Wild-Type Variants and Familial Amyloid Cardiomyopathy Open
Transthyretin (TTR) cardiac amyloidosis is a progressive condition characterized by amyloid fibril deposition in the heart, leading to heart failure. This review focuses on insights into wild-type (ATTRwt) and familial (ATTRm) variants of …
View article: Age-Associated Activation of the cGAS-STING Pathway and Impairment of DNA Damage Repair in Human Primary Alveolar Type II Cells
Age-Associated Activation of the cGAS-STING Pathway and Impairment of DNA Damage Repair in Human Primary Alveolar Type II Cells Open
Homeostatic imbalance and lung function decline are central physiological characteristics of aging and susceptibility to respiratory diseases. Senescence contributes to tissue damage and alveolar epithelial cell injury and decreases repara…
View article: The Regulation of Fatty Acid Synthase by Exosomal miR-143-5p and miR-342-5p in Idiopathic Pulmonary Fibrosis
The Regulation of Fatty Acid Synthase by Exosomal miR-143-5p and miR-342-5p in Idiopathic Pulmonary Fibrosis Open
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive disease caused by an aberrant repair of injured alveolar epithelial cells. The maintenance of the alveolar epithelium and its regeneration after the damage is fueled by alveo…
View article: Caveolin-1-derived peptide attenuates cigarette smoke-induced airway and alveolar epithelial injury
Caveolin-1-derived peptide attenuates cigarette smoke-induced airway and alveolar epithelial injury Open
Chronic cigarette smoke (CS) exposure remains a major risk factor for the pathogenesis of COPD, a debilitating disease with no effective treatment. Increased caveolin-1 mediated induction of p53 and downstream plasminogen activator inhibit…
View article: Mitochondrial Ribosome Dysfunction in Human Alveolar Type II Cells in Emphysema
Mitochondrial Ribosome Dysfunction in Human Alveolar Type II Cells in Emphysema Open
Pulmonary emphysema is characterized by airspace enlargement and the destruction of alveoli. Alveolar type II (ATII) cells are very abundant in mitochondria. OXPHOS complexes are composed of proteins encoded by the mitochondrial and nuclea…
View article: Contribution of dipeptidyl peptidase 4 to non-typeable <i>Haemophilus influenzae</i>-induced lung inflammation in COPD
Contribution of dipeptidyl peptidase 4 to non-typeable <i>Haemophilus influenzae</i>-induced lung inflammation in COPD Open
Dipeptidyl peptidase 4 (DPP4) expression is increased in the lungs of chronic obstructive pulmonary disease (COPD). DPP4 is known to be associated with inflammation in various organs, including LPS-induced acute lung inflammation. Since no…
View article: Expression of SARS-CoV-2 Entry Factors in Human Alveolar Type II Cells in Aging and Emphysema
Expression of SARS-CoV-2 Entry Factors in Human Alveolar Type II Cells in Aging and Emphysema Open
Alveolar type II (ATII) cells proliferate and restore the injured epithelium. It has been described that SARS-CoV-2 infection causes diffuse alveolar damage in the lungs. However, host factors facilitating virus infection in ATII cells are…
View article: The Mitochondrial Ribosome Dysfunction in Human Primary Alveolar Type II Cells in Emphysema
The Mitochondrial Ribosome Dysfunction in Human Primary Alveolar Type II Cells in Emphysema Open
View article: Microarray analysis identifies defects in regenerative and immune response pathways in COPD airway basal cells
Microarray analysis identifies defects in regenerative and immune response pathways in COPD airway basal cells Open
Background Airway basal cells are specialised stem cells and regenerate airway epithelium. Airway basal cells isolated from patients with COPD regenerate airway epithelium with an abnormal phenotype. We performed gene expression analysis t…
View article: Caveolin-1-Derived Peptide Limits Development of Pulmonary Fibrosis
Caveolin-1-Derived Peptide Limits Development of Pulmonary Fibrosis Open
View article: Rhinovirus-Induced SIRT-1 via TLR2 Regulates Subsequent Type I and Type III IFN Responses in Airway Epithelial Cells
Rhinovirus-Induced SIRT-1 via TLR2 Regulates Subsequent Type I and Type III IFN Responses in Airway Epithelial Cells Open
IFN responses to viral infection are necessary to establish intrinsic antiviral state, but if unchecked can lead to heightened inflammation. Recently, we showed that TLR2 activation contributes to limitation of rhinovirus (RV)–induced IFN …
View article: Mitochondrial dysfunction in human primary alveolar type II cells in emphysema
Mitochondrial dysfunction in human primary alveolar type II cells in emphysema Open
View article: The relationship between DJ-1 and S100A8 in human primary alveolar type II cells in emphysema
The relationship between DJ-1 and S100A8 in human primary alveolar type II cells in emphysema Open
Pulmonary emphysema is characterized by alveolar type II (ATII) cell death, destruction of alveolar wall septa, and irreversible airflow limitation. Cigarette smoke induces oxidative stress and is the main risk factor for this disease deve…
View article: Impaired non-homologous end joining in human primary alveolar type II cells in emphysema
Impaired non-homologous end joining in human primary alveolar type II cells in emphysema Open
View article: Inflammatory signature in lung tissues in patients with combined pulmonary fibrosis and emphysema
Inflammatory signature in lung tissues in patients with combined pulmonary fibrosis and emphysema Open
Background: The aetiology and inflammatory profile of combined pulmonary fibrosis and emphysema (CPFE) remain uncertain currently. Objective: We aimed to examine the levels of inflammatory proteins in lung tissue in a cohort …
View article: Inflammatory signature in lung tissues in patients with combined pulmonary fibrosis and emphysema
Inflammatory signature in lung tissues in patients with combined pulmonary fibrosis and emphysema Open
Background: The aetiology and inflammatory profile of combined pulmonary fibrosis and emphysema (CPFE) remain uncertain currently. Objective: We aimed to examine the levels of inflammatory proteins in lung tissue in a cohort …
View article: The cytoprotective role of DJ-1 and p45 NFE2 against human primary alveolar type II cell injury and emphysema
The cytoprotective role of DJ-1 and p45 NFE2 against human primary alveolar type II cell injury and emphysema Open