Explanipedia

Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes Open

Declan Whyte, S Fisher, Christopher G J McKenzie, David Sumpton, Sandeep Dhayade , et al. · 2025

Understanding mechanisms that facilitate early events in metastatic seeding is key to developing therapeutic approaches to reduce metastasis. Here we identify uracil as a metastasis-associated metabolite in genetically engineered mouse mod…

Metabolic adaptations of micrometastases alter EV production to generate invasive microenvironments Open

Michalis Gounis, América Campos, Engy Shokry, Louise Mitchell, Ruhi Deshmukh , et al. · 2025

Altered cellular metabolism has been associated with the acquisition of invasive phenotypes during metastasis. To study this, we combined a genetically engineered mouse model of mammary carcinoma with syngeneic transplantation and primary …

Human-correlated genetic models identify precision therapy for liver cancer Open

Miryam Müller, Stephanie May, H. G. HALL, Timothy J. Kendall, Lynn McGarry , et al. · 2025

Metabolic adaptations of micrometastases alter EV production to generate invasive microenvironments Open

Michalis Gounis, America V. Campos, Engy Shokry, Louise Mitchell, Emmanuel Dornier , et al. · 2024

Altered cellular metabolism has been associated with acquisition of invasive phenotypes during metastasis. To study this, we combined a genetically engineered mouse model of mammary carcinoma with syngeneic transplantation and primary tumo…

Author Correction: Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix Open

Emily Kay, Karla Paterson, Carla Riera‐Domingo, David Sumpton, J. Henry M. Däbritz , et al. · 2022

Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix Open

Emily Kay, Karla Paterson, Carla Riera‐Domingo, David Sumpton, J. Henry M. Däbritz , et al. · 2022

Human-correlated genetic HCC models identify combination therapy for precision medicine Open

Miryam Müller, Stephanie May, H. G. HALL, Timothy J. Kendall, Lynn McGarry , et al. · 2022

Hepatocellular carcinoma (HCC), the most common form of primary liver cancer, is a leading cause of cancer related mortality worldwide. HCC occurs typically from a background of chronic liver disease, caused by a spectrum of predisposing c…

Corrigendum: Differential requirements for MDM2 E3 activity during embryogenesis and in adult mice Open

Timothy J. Humpton, Koji Nomura, Julia Weber, H Magnussen, Andreas Hock , et al. · 2021

In the above-mentioned paper, the authors describe the generation of Cre-inducible Mdm2 I438K/I438K mice derived from mice carrying the tm1.1 allele (Supplemental Fig. S1H).In fact, these mice were generated using the tm1 allele, which is …

Breast cancer dependence on MCL-1 is due to its canonical anti-apoptotic function Open

Kirsteen J. Campbell, Susan Mason, Matthew L. Winder, Rosalie B. E. Willemsen, Catherine Cloix , et al. · 2021

High levels of the anti-apoptotic BCL-2 family member MCL-1 are frequently found in breast cancer and, appropriately, BH3-mimetic drugs that specifically target MCL-1’s function in apoptosis are in development as anti-cancer therapy. MCL-1…

Differential requirements for MDM2 E3 activity during embryogenesis and in adult mice Open

Timothy J. Humpton, Koji Nomura, Julia Weber, H Magnussen, Andreas Hock , et al. · 2020

The p53 tumor suppressor protein is a potent activator of proliferative arrest and cell death. In normal cells, this pathway is restrained by p53 protein degradation mediated by the E3-ubiquitin ligase activity of MDM2. Oncogenic stress re…

Impact of Formate Supplementation on Body Weight and Plasma Amino Acids Open

Sandeep Dhayade, Matthias Pietzke, Robert Wiesheu, Jacqueline Tait-Mulder, Dimitris Athineos , et al. · 2020

Current nutritional recommendations are focused on energy, fat, carbohydrate, protein and vitamins. Less attention has been paid to the nutritional demand of one-carbon units for nucleotide and methionine synthesis. Here, we investigated t…

The MSP‐RON axis stimulates cancer cell growth in models of triple negative breast cancer Open

Rhona Millar, Anna Kilbey, Sarah-Jane Remak, Tesa Severson, Sandeep Dhayade , et al. · 2020

Triple‐negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with poor prognosis and high rates of relapse. The lack of actionable targets for TNBC has contributed to the high mortality rates of this disease, and ne…

PYCR1-dependent proline synthesis in cancer-associated fibroblasts is required for the deposition of pro-tumorigenic extracellular matrix Open

Emily Kay, Karla Paterson, David Sumpton, Ekaterina Stepanova, Claudia Boldrini , et al. · 2020

TElevated production of collagen-rich extracellular matrix (ECM) is a hallmark of cancer associated fibroblasts (CAFs) and a central driver of cancer aggressiveness. How to target ECM production to oppose cancer is yet unclear, since targe…

Impact of formate supplementation on body weight and plasma amino acids Open

Sandeep Dhayade, Matthias Pietzke, Robert Wiesheu, Jacqueline Tait-Mulder, Dimitris Athineos , et al. · 2020

Current nutritional recommendations are focused on energy, fat, carbohydrate, protein and vitamins. Less attention has been paid to the nutritional demand of one-carbon units for nucleotide and methionine synthesis. Here we investigate the…

Formate induces a metabolic switch in nucleotide and energy metabolism Open

Kristell Oizel, Jacqueline Tait-Mulder, Jorge Fernández-de-Cossio-Díaz, Matthias Pietzke, Holly Brunton , et al. · 2020

The MSP-RON axis stimulates cancer cell growth in models of triple negative breast cancer Open

Rhona Millar, Anna Kilbey, Sarah-Jane Remak, Tesa Severson, Sandeep Dhayade , et al. · 2020

Triple negative breast cancer is the most aggressive subtype of breast cancer with poor prognosis and high rates of relapse. The lack of actionable targets for TNBC has contributed to the high mortality rates of this disease, and new candi…

Formate induces a metabolic switch in nucleotide and energy metabolism Open

Kristell Oizel, Jacqueline Tait-Mulder, Jorge Fernández-de-Cossio-Díaz, Matthias Pietzke, Holly Brunton , et al. · 2019

Formate is a precursor for the de novo synthesis of purine and deoxythymidine nucleotides. Formate also interacts with energy metabolism by promoting the synthesis of adenine nucleotides. Here we use theoretical modelling together with met…

A Unique Panel of Patient-Derived Cutaneous Squamous Cell Carcinoma Cell Lines Provides a Preclinical Pathway for Therapeutic Testing Open

Sakinah Hassan, Karin J. Purdie, Jun Wang, Catherine Harwood, Charlotte M. Proby , et al. · 2019

Background: Cutaneous squamous cell carcinoma (cSCC) incidence continues to rise with increasing morbidity and mortality, with limited treatment options for advanced disease. Future improvements in targeted therapy will rely on advances in…

Formate Induces a Metabolic Switch in Nucleotide and Energy Metabolism Open

Kristell Oizel, Jacqueline Tait-Mulder, Jorge Fernández-de-Cossio-Díaz, Matthias Pietzke, Holly Brunton , et al. · 2019

Increased formate overflow is a hallmark of oxidative cancer Open

Johannes Meiser, Anne Schuster, Matthias Pietzke, Johan Vande Voorde, Dimitris Athineos , et al. · 2018

MCL-1 is a prognostic indicator and drug target in breast cancer Open

Kirsteen J. Campbell, Sandeep Dhayade, Nicola Ferrari, Andrew H. Sims, Emma Johnson , et al. · 2018

Analysis of publicly available genomic and gene expression data demonstrates that MCL1 expression is frequently elevated in breast cancer. Distinct from other pro-survival Bcl-2 family members, the short half-life of MCL-1 protein led us t…

Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells Open

Emmanuel Dornier, Nicolas Rabas, Louise Mitchell, David Novo, Sandeep Dhayade , et al. · 2017

PyMT-Maclow: A novel, inducible, murine model for determining the role of CD68 positive cells in breast tumor development Open

Robin M. H. Rumney, Seth B. Coffelt, Terence A. Neale, Sandeep Dhayade, Gillian M. Tozer , et al. · 2017

CD68+ tumor-associated macrophages (TAMs) are pro-tumorigenic, pro-angiogenic and are associated with decreased survival rates in patients with cancer, including breast cancer. Non-specific models of macrophage ablation reduce the number o…

Tumor matrix stiffness promotes metastatic cancer cell interaction with the endothelium Open

Steven Reid, Emily Kay, Lisa J. Neilson, Anne‐Theres Henze, Jens Serneels , et al. · 2017

Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity Open

Juan R. Hernández‐Fernaud, Elena Ruengeler, Andrea Casazza, Lisa J. Neilson, Ellie Pulleine , et al. · 2017

Acetate Recapturing by Nuclear Acetyl-CoA Synthetase 2 Prevents Loss of Histone Acetylation during Oxygen and Serum Limitation Open

Vinay Bulusu, Sergey Tumanov, Evdokia Michalopoulou, Niels J. van den Broek, Gillian Mackay , et al. · 2017

Acetyl-CoA is a key metabolic intermediate with an important role in transcriptional regulation. The nuclear-cytosolic acetyl-CoA synthetase 2 (ACSS2) was found to sustain the growth of hypoxic tumor cells. It generates acetyl-CoA from ace…

Sildenafil Potentiates a cGMP-Dependent Pathway to Promote Melanoma Growth Open

Sandeep Dhayade, Susanne Kaesler, Tobias Sinnberg, Hyazinth Dobrowinski, Stefanie Peters , et al. · 2016

A CNP-cGMP-cGKI-MAPK pathway promotes melanoma growth in vitro and in vivo in mice Open

Sandeep Dhayade, Susanne Feil, Anja Ulmer, Susanne Kaesler, Tobias Sinnberg , et al. · 2015

Several important effects of nitric oxide (NO) and natriuretic peptides (ANP, BNP, & CNP) are mediated by cyclic guanosine monophosphate (cGMP) and cGMP-dependent protein kinase type I (cGKI). Recent studies indicated that the cGMP pathway…

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