Sandeep Mathur
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View article: Whole-exome sequencing for identification of specific gene mutations in an Indian cohort of triple-negative breast cancer patients
Whole-exome sequencing for identification of specific gene mutations in an Indian cohort of triple-negative breast cancer patients Open
View article: Pertuzumab/Docetaxel/Carboplatin/Trastuzumab Regimen in Human Epidermal Growth Factor Receptor 2–Positive Early, Locally Advanced, and Oligometastatic Breast Cancer: Real-World Outcomes From India
Pertuzumab/Docetaxel/Carboplatin/Trastuzumab Regimen in Human Epidermal Growth Factor Receptor 2–Positive Early, Locally Advanced, and Oligometastatic Breast Cancer: Real-World Outcomes From India Open
PURPOSE The study evaluated the real-world outcomes of the pertuzumab/docetaxel/carboplatin/trastuzumab (PTCH) regimen in Indian patients with human epidermal growth factor receptor 2–positive (HER2+) early, locally advanced, and oligometa…
View article: Development and performance test of p-type Silicon pad array detector
Development and performance test of p-type Silicon pad array detector Open
This article reports on the development and comprehensive evaluation of p-type silicon detector arrays fabricated at the Semi-Conductor Laboratory (SCL), Mohali, India. The detectors consist of an 8~$\times$~9 array of 1~$\times$~1~cm$^2$ …
View article: 107P Identification of novel targets in residual triple-negative breast cancer post-neoadjuvant chemoimmunotherapy to personalise adjuvant treatment
107P Identification of novel targets in residual triple-negative breast cancer post-neoadjuvant chemoimmunotherapy to personalise adjuvant treatment Open
View article: Adenoid Cystic Carcinoma of the Breast – A Rare Case Report
Adenoid Cystic Carcinoma of the Breast – A Rare Case Report Open
A BSTRACT Adenoid cystic carcinoma (ACC) of the breast is very rare, constituting < 0.1% of all breast cancers. ACC breast is usually triple negative. Interestingly, it has been shown to farewell with very low recurrence rates in contrast …
View article: Massive edema of ovary masquerading as neoplasm in a preteen girl
Massive edema of ovary masquerading as neoplasm in a preteen girl Open
Massive ovarian oedema, though rare, frequently mimics an ovarian neoplasm, both clinically and radiologically. Here, we discuss the case of a 12-year-old girl who presented with intermittent pain in the lower abdomen for last one month as…
View article: Role of MRI in evaluation of residual tumor burden following neoadjuvant therapy in patients with breast cancer
Role of MRI in evaluation of residual tumor burden following neoadjuvant therapy in patients with breast cancer Open
Objectives To correlate the accuracy of MRI with pathology in assessing the response of neoadjuvant chemotherapy (NACT) in patients with breast cancer and assessment of factors affecting the accuracy of MRI. Materials and Methods Twenty-fi…
View article: Experience of a tertiary care institute on the spectrum of fine-needle aspiration of hepatic nodular lesions from North India
Experience of a tertiary care institute on the spectrum of fine-needle aspiration of hepatic nodular lesions from North India Open
Background: Fine needle aspiration cytology (FNAC) of hepatic nodular lesions is common to characterize hepatic lesions, and in this retrospective study, we analyzed the spectrum of primary and secondary hepatic lesions identified over 4 y…
View article: Patterns of care for vulvar cancer and insights from revised FIGO staging: a retrospective study
Patterns of care for vulvar cancer and insights from revised FIGO staging: a retrospective study Open
View article: Prognostic role of Androgen Receptor splice variant 7 (AR-V7) in the pathogenesis of breast cancer
Prognostic role of Androgen Receptor splice variant 7 (AR-V7) in the pathogenesis of breast cancer Open
Our study unravels AR-V7 as a marker for poor clinical outcomes, predicting breast cancer aggressiveness, and encourages consideration of AR-V7 as a probable target for therapeutic intervention.
View article: Adeno-squamous carcinoma of bartholin gland: Challenges in diagnosis and management of a less known vulvar cancer – A case report
Adeno-squamous carcinoma of bartholin gland: Challenges in diagnosis and management of a less known vulvar cancer – A case report Open
Bartholin gland carcinoma is one of the less common histology accounting for 0.1 – 5 % of all vulvar malignancies and is mostly seen in postmenopausal women. It accounts for 0.001 % of all female malignancies. Clinical presentation is dela…
View article: Prognostic Role of Androgen Receptor Splice Variant 7 (AR-V7) in the Pathogenesis of Breast Cancer
Prognostic Role of Androgen Receptor Splice Variant 7 (AR-V7) in the Pathogenesis of Breast Cancer Open
Background: The Androgen Receptor (AR) has emerged as an endocrine therapy target in Breast Cancer, exhibiting up to 80% expression in clinical cases. AR-V7, a constitutively activated splice variant of AR with a truncated ligand-binding d…
View article: Somatic mutational landscape across Indian breast cancer cases by whole exome sequencing
Somatic mutational landscape across Indian breast cancer cases by whole exome sequencing Open
View article: Exploring the role of SOX 2 and OCT 4 in the pathogenesis of gliomatosis peritonei: the clinicopathological profile of eleven cases
Exploring the role of SOX 2 and OCT 4 in the pathogenesis of gliomatosis peritonei: the clinicopathological profile of eleven cases Open
A possibility of GP should be considered as a differential, clinically and radiologically, in cases of omental nodularity. Adequate sampling at the time of surgery is essential to rule out metastasis or growing teratoma syndrome. SOX2, a s…
View article: Spectroscopic insight into breast cancer: profiling small extracellular vesicles lipids via infrared spectroscopy for diagnostic precision
Spectroscopic insight into breast cancer: profiling small extracellular vesicles lipids via infrared spectroscopy for diagnostic precision Open
View article: Whole exome sequencing for identification of specific gene mutations in an Indian cohort of triple- negative breast cancer patients
Whole exome sequencing for identification of specific gene mutations in an Indian cohort of triple- negative breast cancer patients Open
Background: Triple-negative breast cancers (TNBCs) are pathologically the most aggressive and heterogenous subtype of carcinoma breast displaying increased chemo-resistance and a high rate of relapse. A compelling need exists to discover s…
View article: Comprehensive germline profiling of patients with breast cancer: initial experience from a Familial Cancer Clinic
Comprehensive germline profiling of patients with breast cancer: initial experience from a Familial Cancer Clinic Open
We report a 41% P/LP variant rate in our selected cohort of breast cancer patients, with variants in BRCA constituting 83% and non-BRCA gene variants constituting 17%.
View article: Exploring Molecular Alterations in Breast Cancer Among Indian Women Using Label‐Free Quantitative Serum Proteomics
Exploring Molecular Alterations in Breast Cancer Among Indian Women Using Label‐Free Quantitative Serum Proteomics Open
The clinical data indicate that diverse parameters characterize breast cancer patients in India, including age at presentation, risk factors, outcomes, and behavior. Alarming incidence and mortality rates emphasize the crucial need for ear…
View article: Establishment of Cut-off Values for Uterine and Peripheral Blood Natural Killer Cells During the Peri-implantation Period in Fertile Controls and Women with Unexplained Recurrent Implantation Failure
Establishment of Cut-off Values for Uterine and Peripheral Blood Natural Killer Cells During the Peri-implantation Period in Fertile Controls and Women with Unexplained Recurrent Implantation Failure Open
Background: The purpose of the study was to determine the cut-off values for peripheral and uterine natural killer (pNK, uNK) cells in fertile controls and in women with recurrent implantation failure (RIF). Methods: In this study, 50 wome…
View article: Identification of somatic mutational landscape across Indian breast cancer cases by whole exome sequencing.
Identification of somatic mutational landscape across Indian breast cancer cases by whole exome sequencing. Open
Breast cancer (BC) has emerged as the most common malignancy among females. The genomic profile of BC is diverse in nature and complex due to heterogeneity among various geographically different ethnic groups. The primary objective of this…
View article: Imaging features of breast cancer subtypes on contrast enhanced ultrasound: a feasibility study
Imaging features of breast cancer subtypes on contrast enhanced ultrasound: a feasibility study Open
The objective of this research was to study the contrast enhancement patterns of the different molecular subtypes of breast cancer on contrast-enhanced ultrasound (CEUS) using both qualitative and quantitative parameters. This prospective …
View article: W002/#1410 Novel strategy of training the accredited social health activists (ASHAS) via telemedicine for cervical cancer screening by HPV self-sampling – the track trial
W002/#1410 Novel strategy of training the accredited social health activists (ASHAS) via telemedicine for cervical cancer screening by HPV self-sampling – the track trial Open
Introduction This is a novel, pilot study aimed to analyse training of ASHAs by telemedicine for counselling women for cervical cancer screening by HPV Self-Sampling. Methods This study is a pilot, community-based, prospective, single-arm …
View article: EP207/#760 Investigating the clinicopathological characteristics of 11 cases of gliomatosis peritonei and exploring the potential role of SOX 2 and OCT 4 in their development
EP207/#760 Investigating the clinicopathological characteristics of 11 cases of gliomatosis peritonei and exploring the potential role of SOX 2 and OCT 4 in their development Open
Introduction Gliomatosis peritonei (GP) is a rare condition characterized by multiple mature glial tissue implants in the peritoneum and omentum. Mostly associated with immature teratomas (IMT), these are benign nodular implants that remai…
View article: Claudin‐4 immunocytochemistry is specific and sensitive for the diagnosis of malignant carcinomatous effusions: Results from a pilot study
Claudin‐4 immunocytochemistry is specific and sensitive for the diagnosis of malignant carcinomatous effusions: Results from a pilot study Open
Background Claudin‐4, a tight junction associated protein expressed in epithelial cells, is purported as a highly specific and sensitive marker for epithelial malignancies. Our aim was to assess the sensitivity, specificity and real‐time u…
View article: Whole exome sequencing identifies novel variants of PIK3CA and validation of hotspot mutation by droplet digital PCR in breast cancer among Indian population
Whole exome sequencing identifies novel variants of PIK3CA and validation of hotspot mutation by droplet digital PCR in breast cancer among Indian population Open
Background Breast cancer (BC) is the most common malignancy with very high incidence and relatively high mortality in women. The PIK3CA gene plays a pivotal role in the pathogenicity of breast cancer. Despite this, the mutational status of…
View article: Derangement of metabolic homeostasis, detoxifying ability and CA 15-3 in young adult female rats by fructose (15%) drinking is akin to known carcinogens: A missed fiend?
Derangement of metabolic homeostasis, detoxifying ability and CA 15-3 in young adult female rats by fructose (15%) drinking is akin to known carcinogens: A missed fiend? Open
Objectives: Breast cancer (BC) has been the bane of peri-and post-menopausal women, but is now increasingly incident in adolescent/young adult (AYA) females. Pari-passu , there has been a >1000% increase in consumption of fructose as a cal…
View article: Dose-dense neoadjuvant chemotherapy in triple-negative breast cancer: Real-world data from a developing country
Dose-dense neoadjuvant chemotherapy in triple-negative breast cancer: Real-world data from a developing country Open
Background: Dose-dense adjuvant chemotherapy has been shown to be associated with improved long-term survival outcomes in triple-negative breast cancer (TNBC). However, there is a lacuna of data on the benefits of dose-dense neoadjuvant ch…
View article: 168P HUWE1 inhibition has tumor suppressive effect in triple-negative breast cancer cell lines by modulating glycolytic and immune modulatory markers
168P HUWE1 inhibition has tumor suppressive effect in triple-negative breast cancer cell lines by modulating glycolytic and immune modulatory markers Open
View article: Whole exome sequencing identifies novel variants of PIK3CA and validation of hotspot mutation by droplet digital PCR in Breast cancer among Indian Population.
Whole exome sequencing identifies novel variants of PIK3CA and validation of hotspot mutation by droplet digital PCR in Breast cancer among Indian Population. Open
Background - Breast cancer (BC) is the most common malignancy with very high incidence and relatively high mortality in women. The PIK3CA gene plays a pivotal role in the pathogenicity of breast cancer. Despite these, the mutational status…
View article: Unveiling the Significance of FGF8 Overexpression in Orchestrating the Progression of Ovarian Cancer
Unveiling the Significance of FGF8 Overexpression in Orchestrating the Progression of Ovarian Cancer Open
The asymptomatic nature, high rate of disease recurrence, and resistance to platinum-based chemotherapy highlight the need to identify and characterize novel target molecules for ovarian cancer. Fibroblast growth factor 8 (FGF8) aids in th…