Sandeep Robert Datta
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View article: Altered striatal dopamine dynamics and behavior in <i>Grin2a</i> mutant mice, a genetic mouse model of schizophrenia
Altered striatal dopamine dynamics and behavior in <i>Grin2a</i> mutant mice, a genetic mouse model of schizophrenia Open
Schizophrenia (SCZ), a complex psychiatric disorder with a strong genetic basis, is thought to involve, at least in part, dopamine dysregulation in the striatum. Recent large-scale exome sequencing has identified multiple SCZ risk genes, i…
View article: Brain wide engraftment of human monocytes induces neurodegeneration and cognitive dysfunction
Brain wide engraftment of human monocytes induces neurodegeneration and cognitive dysfunction Open
View article: 1-011 Utility of serial NT-proBNP measurement in the management of immune-checkpoint inhibitor-related myocarditis
1-011 Utility of serial NT-proBNP measurement in the management of immune-checkpoint inhibitor-related myocarditis Open
View article: A spatial code governs olfactory receptor choice and aligns sensory maps in the nose and brain
A spatial code governs olfactory receptor choice and aligns sensory maps in the nose and brain Open
Although topographical maps organize many peripheral sensory systems, it remains unclear whether olfactory sensory neurons (OSNs) choose which of the ∼1100 odor receptors (ORs) to express based upon their spatial location in the olfactory …
View article: Author response: Dynamics of striatal action selection and reinforcement learning
Author response: Dynamics of striatal action selection and reinforcement learning Open
View article: Dynamics of striatal action selection and reinforcement learning
Dynamics of striatal action selection and reinforcement learning Open
Spiny projection neurons (SPNs) in dorsal striatum are often proposed as a locus of reinforcement learning in the basal ganglia. Here, we identify and resolve a fundamental inconsistency between striatal reinforcement learning models and k…
View article: Author response: Dynamics of striatal action selection and reinforcement learning
Author response: Dynamics of striatal action selection and reinforcement learning Open
View article: Dynamics of striatal action selection and reinforcement learning
Dynamics of striatal action selection and reinforcement learning Open
Spiny projection neurons (SPNs) in dorsal striatum are often proposed as a locus of reinforcement learning in the basal ganglia. Here, we identify and resolve a fundamental inconsistency between striatal reinforcement learning models and k…
View article: Dynamics of striatal action selection and reinforcement learning
Dynamics of striatal action selection and reinforcement learning Open
Spiny projection neurons (SPNs) in dorsal striatum are often proposed as a locus of reinforcement learning in the basal ganglia. Here, we identify and resolve a fundamental inconsistency between striatal reinforcement learning models and k…
View article: Dynamics of striatal action selection and reinforcement learning
Dynamics of striatal action selection and reinforcement learning Open
Spiny projection neurons (SPNs) in dorsal striatum are often proposed as a locus of reinforcement learning in the basal ganglia. Here, we identify and resolve a fundamental inconsistency between striatal reinforcement learning models and k…
View article: A Perspective on Neuroscience Data Standardization with Neurodata Without Borders
A Perspective on Neuroscience Data Standardization with Neurodata Without Borders Open
Neuroscience research has evolved to generate increasingly large and complex experimental data sets, and advanced data science tools are taking on central roles in neuroscience research. Neurodata Without Borders (NWB), a standard language…
View article: Thyroid hormone remodels cortex to coordinate body-wide metabolism and exploration
Thyroid hormone remodels cortex to coordinate body-wide metabolism and exploration Open
View article: Concerted modulation of spontaneous behavior and time-integrated whole-brain neuronal activity by serotonin receptors
Concerted modulation of spontaneous behavior and time-integrated whole-brain neuronal activity by serotonin receptors Open
Serotonin neurons from the raphe nuclei project across the entire brain and modulate diverse physiology and behavior by acting on over a dozen receptors. Here, we took a step towards dissecting this complex process by examining the effects…
View article: Keypoint-MoSeq: parsing behavior by linking point tracking to pose dynamics
Keypoint-MoSeq: parsing behavior by linking point tracking to pose dynamics Open
View article: Metabotropic signaling within somatostatin interneurons controls transient thalamocortical inputs during development
Metabotropic signaling within somatostatin interneurons controls transient thalamocortical inputs during development Open
View article: Characterizing the structure of mouse behavior using Motion Sequencing
Characterizing the structure of mouse behavior using Motion Sequencing Open
View article: MODIFIED DISCRETE WAVELET FEATURES FOR PHONEME RECOGNITION
MODIFIED DISCRETE WAVELET FEATURES FOR PHONEME RECOGNITION Open
View article: Systems Neuro Browser (SNUB)
Systems Neuro Browser (SNUB) Open
A core goal of neuroscience is to discover temporal patterns in behavior and neurophysiology.Though a variety of tools exist to characterize these relationships, there is still no substitute for direct inspection as a way to notice unexpec…
View article: THE FRACTAL CHARACTERISATION OF ISOLATED HUMAN SPEECH
THE FRACTAL CHARACTERISATION OF ISOLATED HUMAN SPEECH Open
View article: Social touch shapes communication and animal recognition in naked mole-rats
Social touch shapes communication and animal recognition in naked mole-rats Open
Summary The East African naked mole-rat ( Heterocephalus glaber ) lives in cooperative subterranean colonies and displays a capacity to recognize social novelty, rank, and identity. The sensory cues used for social recognition remain poorl…
View article: Dynamics of striatal action selection and reinforcement learning
Dynamics of striatal action selection and reinforcement learning Open
Spiny projection neurons (SPNs) in dorsal striatum are often proposed as a locus of reinforcement learning in the basal ganglia. Here, we identify and resolve a fundamental inconsistency between striatal reinforcement learning models and k…
View article: AUTOMATIC DOLPHIN WHISTLE DETECTION, EXTRACTION, ENCODING AND CLASSIFICATION
AUTOMATIC DOLPHIN WHISTLE DETECTION, EXTRACTION, ENCODING AND CLASSIFICATION Open
The Underwater Acoustics Group at Loughbcrough University has developed software for quantitative comparison of frequency modulated tonal sounds, specifically for those produced by dolphins [1,2,3].The software can identify parts of record…
View article: DOLPHIN WHISTLE CLASSIFICATION WITH THE 'DOLPHIN' SOFTWARE
DOLPHIN WHISTLE CLASSIFICATION WITH THE 'DOLPHIN' SOFTWARE Open
View article: ECHOLOCATION SOUND SOURCES IN THE HARBOUR PORPOISE - A WAVELET APPROACH TO CLASSIFICATION
ECHOLOCATION SOUND SOURCES IN THE HARBOUR PORPOISE - A WAVELET APPROACH TO CLASSIFICATION Open
While testing acoustic signals designed to mitigate harbour porpoise by-catch mortality in commercial gillnets, a large volume ofecholocation activityfrom a pair offree-swimmin g harbour porpoises (Phocoena phocoena) was recorded for behav…
View article: Revealing motor behavior patterns and functional improvement trajectories following spinal cord injury using unsupervised machine learning
Revealing motor behavior patterns and functional improvement trajectories following spinal cord injury using unsupervised machine learning Open
Spinal cord injury (SCI) disrupts motor function, with recovery involving complex adaptive motor behaviors that cannot be fully assessed with traditional manual recovery assessments and their predefined recovery criteria. To move beyond th…
View article: A perspective on neuroscience data standardization with Neurodata Without Borders
A perspective on neuroscience data standardization with Neurodata Without Borders Open
Neuroscience research has evolved to generate increasingly large and complex experimental data sets, and advanced data science tools are taking on central roles in neuroscience research. Neurodata Without Borders (NWB), a standard language…
View article: Metabotropic signaling within somatostatin interneurons controls transient thalamocortical inputs during development
Metabotropic signaling within somatostatin interneurons controls transient thalamocortical inputs during development Open
During brain development, neural circuits undergo major activity-dependent restructuring. Circuit wiring mainly occurs through synaptic strengthening following the Hebbian “fire together, wire together” precept. However, select connections…
View article: Mammalian olfactory cortex neurons retain molecular signatures of ancestral cell types
Mammalian olfactory cortex neurons retain molecular signatures of ancestral cell types Open
The cerebral cortex diversified extensively during vertebrate evolution. Intriguingly, the three-layered mammalian olfactory cortex resembles the cortical cytoarchitecture of non-mammals yet evolved alongside the six-layered neocortex, ena…
View article: Brain region-specific changes in neurons and glia and dysregulation of dopamine signaling in Grin2a mutant mice
Brain region-specific changes in neurons and glia and dysregulation of dopamine signaling in Grin2a mutant mice Open
Schizophrenia disease mechanisms remain poorly understood, in large part due to a lack of valid animal models. Rare heterozygous loss-of-function mutations in GRIN2A, encoding a subunit of the NMDA (N-methyl-d-aspartate) receptor,…
View article: Brain region-specific changes in neurons and glia and dysregulation of dopamine signaling in Grin2a mutant mice
Brain region-specific changes in neurons and glia and dysregulation of dopamine signaling in Grin2a mutant mice Open
Schizophrenia disease mechanisms remain poorly understood, in large part due to a lack of valid animal models. Rare heterozygous loss-of-function mutations in GRIN2A, encoding a subunit of the NMDA (N-methyl-d-aspartate) receptor,…