Sandeep S.V. Golla
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View article: Predicting 2-year time to progression in diffuse large B cell lymphoma using 3D CNNs on whole-body PET/CT scans
Predicting 2-year time to progression in diffuse large B cell lymphoma using 3D CNNs on whole-body PET/CT scans Open
View article: 89Zr-mAb uptake interpretation requires the use of tissue to plasma ratios corrected for antibody catabolism
89Zr-mAb uptake interpretation requires the use of tissue to plasma ratios corrected for antibody catabolism Open
View article: Predicting 2-Year Time to Progression in diffuse large B cell lymphoma Using 3D CNNs on Whole-Body PET/CT Scans
Predicting 2-Year Time to Progression in diffuse large B cell lymphoma Using 3D CNNs on Whole-Body PET/CT Scans Open
Background . The aim of this study was to develop 3D convolutional neural networks (CNN) for the prediction of 2 years’ time to progression using PET/CT baseline scans from diffuse large B-cell lymphoma (DLBCL) patients. The predictive per…
View article: Neuroinflammation in long-term cognitive impairment after aneurysmal subarachnoid hemorrhage
Neuroinflammation in long-term cognitive impairment after aneurysmal subarachnoid hemorrhage Open
Background: Survivors of aneurysmal subarachnoid hemorrhage (aSAH) often have cognitive impairment, which may be caused by long-term inflammation. We aimed to determine whether long-term neuroinflammation or microstructural brain damage is…
View article: 410 | EVALUATION OF AN ARTIFICIAL INTELLIGENCE METHOD FOR LESION SEGMENTATION OF BASELINE FDG PET STUDIES OF DLBCL PATIENTS
410 | EVALUATION OF AN ARTIFICIAL INTELLIGENCE METHOD FOR LESION SEGMENTATION OF BASELINE FDG PET STUDIES OF DLBCL PATIENTS Open
View article: 11 | PREDICTING 2‐YEAR TIME TO PROGRESSION IN DIFFUSE LARGE B‐CELL LYMPHOMA USING ARTIFICIAL INTELLIGENCE ON WHOLE‐BODY PET SCANS
11 | PREDICTING 2‐YEAR TIME TO PROGRESSION IN DIFFUSE LARGE B‐CELL LYMPHOMA USING ARTIFICIAL INTELLIGENCE ON WHOLE‐BODY PET SCANS Open
View article: Dynamic PET imaging in patients with unilateral carotid occlusion shows lateralized cerebral hypoperfusion, but no amyloid binding
Dynamic PET imaging in patients with unilateral carotid occlusion shows lateralized cerebral hypoperfusion, but no amyloid binding Open
Background Carotid occlusive disease is a risk factor for cognitive decline. A possible underlying etiology is that hemodynamic impairment results in decreased cerebral perfusion, exacerbated amyloid-β accumulation (Aβ) and poorer cognitiv…
View article: Characterizing visual read tau‐PET‐negative participants with Alzheimer's disease dementia
Characterizing visual read tau‐PET‐negative participants with Alzheimer's disease dementia Open
INTRODUCTION A subset of amyloid beta (Aβ)‐positive Alzheimer's disease (AD) patients is tau‐positron emission tomography (PET) negative. We aimed to characterize this subgroup using [ 18 F]flortaucipir PET visual read (VR), as this is imp…
View article: Evaluation of an artificial intelligence method for lesion segmentation of baseline FDG PET studies of DLBCL patients
Evaluation of an artificial intelligence method for lesion segmentation of baseline FDG PET studies of DLBCL patients Open
Background. The aim of this study is to investigate the use of an artificial intelligence (AI) method, LIONZ, in combination with an intensity-based threshold method, SUV4.0, for the automatic selection and segmentation of diffuse large B …
View article: Tau‐PET signal in Alzheimer’s disease is related to immune activation and synaptic signaling measured with CSF proteomics
Tau‐PET signal in Alzheimer’s disease is related to immune activation and synaptic signaling measured with CSF proteomics Open
Background Tau tangles are one of the pathological hallmarks of Alzheimer’s disease (AD) and can be quantified using PET. It remains unclear which molecular processes are related to tau aggregation. Protein levels in CSF can be used to stu…
View article: Longitudinal tau binding in tau‐PET negative patients with clinical Alzheimer’s disease
Longitudinal tau binding in tau‐PET negative patients with clinical Alzheimer’s disease Open
Background Different tau‐PET patterns have been observed in Alzheimer’s disease (AD) which may be associated with demographic factors, copathology and resilience. We and others previously found that not all Aβ‐positive AD patients are tau‐…
View article: Head-to-head comparison of relative cerebral blood flow derived from dynamic [18F]florbetapir and [18F]flortaucipir PET in subjects with subjective cognitive decline
Head-to-head comparison of relative cerebral blood flow derived from dynamic [18F]florbetapir and [18F]flortaucipir PET in subjects with subjective cognitive decline Open
View article: Sensitivity of an AI method for [18F]FDG PET/CT outcome prediction of diffuse large B-cell lymphoma patients to image reconstruction protocols
Sensitivity of an AI method for [18F]FDG PET/CT outcome prediction of diffuse large B-cell lymphoma patients to image reconstruction protocols Open
Background Convolutional neural networks (CNNs), applied to baseline [ 18 F]-FDG PET/CT maximum intensity projections (MIPs), show potential for treatment outcome prediction in diffuse large B-cell lymphoma (DLBCL). The aim of this study i…
View article: Performance of a [ <sup>18</sup> F]Flortaucipir PET Visual Read Method Across the Alzheimer Disease Continuum and in Dementia With Lewy Bodies
Performance of a [ <sup>18</sup> F]Flortaucipir PET Visual Read Method Across the Alzheimer Disease Continuum and in Dementia With Lewy Bodies Open
This study provides Class II evidence that [18F]flortaucipir visual read accurately distinguishes patients with low tau-tracer binding from those with high tau-tracer binding and is associated with amyloid positivity and cogniti…
View article: An artificial intelligence method using FDG PET to predict treatment outcome in diffuse large B cell lymphoma patients
An artificial intelligence method using FDG PET to predict treatment outcome in diffuse large B cell lymphoma patients Open
Convolutional neural networks (CNNs) may improve response prediction in diffuse large B-cell lymphoma (DLBCL). The aim of this study was to investigate the feasibility of a CNN using maximum intensity projection (MIP) images from 18 F-fluo…
View article: Altered brain metabolism in frontotemporal dementia and psychiatric disorders: involvement of the anterior cingulate cortex
Altered brain metabolism in frontotemporal dementia and psychiatric disorders: involvement of the anterior cingulate cortex Open
Background Behavioural symptoms and frontotemporal hypometabolism overlap between behavioural variant of frontotemporal dementia (bvFTD) and primary psychiatric disorders (PPD), hampering diagnostic distinction. Voxel-wise comparisons of b…
View article: Sensitivity of an AI method for [18F]FDG PET/CT outcome prediction of Diffuse large B-cell lymphoma patients to image reconstruction protocols.
Sensitivity of an AI method for [18F]FDG PET/CT outcome prediction of Diffuse large B-cell lymphoma patients to image reconstruction protocols. Open
Background Convolutional Neural Networks (CNN), applied to baseline [ 18 F]-FDG PET/CT maximum intensity projections (MIPs) show potential for treatment outcome prediction in diffuse large B-cell lymphoma (DLBCL). The aim of this study is …
View article: Tau protein spreads through functionally connected neurons in Alzheimer’s disease: a combined MEG/PET study
Tau protein spreads through functionally connected neurons in Alzheimer’s disease: a combined MEG/PET study Open
Recent studies on Alzheimer’s disease (AD) suggest that tau proteins spread through the brain following neuronal connections. Several mechanisms could be involved in this process: spreading between brain regions that interact strongly (fun…
View article: Amyloid PET in patients with carotid occlusive disease: Preliminary results of the AMYCODE study
Amyloid PET in patients with carotid occlusive disease: Preliminary results of the AMYCODE study Open
Background Carotid occlusive disease (COD) is a risk factor for cognitive decline. One of the proposed underlying mechanisms is that cerebral hypoperfusion may result in accelerated accumulation of amyloid‐β in the brain. We hypothesized t…
View article: Predicting cortical thickness with [<sup>18</sup>F]flortaucipir PET: A longitudinal MRI study
Predicting cortical thickness with [<sup>18</sup>F]flortaucipir PET: A longitudinal MRI study Open
Background The association between tau pathology and neurodegeneration (atrophy) in Alzheimer’s disease (AD) is not fully understood. This study aimed to investigate whether tau pathology is associated with concurrent and longitudinal cort…
View article: Neurobiological basis and risk factors of persistent fatigue and concentration problems after COVID-19: study protocol for a prospective case–control study (VeCosCO)
Neurobiological basis and risk factors of persistent fatigue and concentration problems after COVID-19: study protocol for a prospective case–control study (VeCosCO) Open
Introduction The risk factors for persistent fatigue and cognitive complaints after infection with SARS-CoV-2 and the underlying pathophysiology are largely unknown. Both clinical factors and cognitive-behavioural factors have been suggest…
View article: Head‐to‐head comparison of Relative Cerebral Blood Flow derived from [<sup>18</sup>F]florbetapir and [<sup>18</sup>F]flortaucipir in subjects with Subjective Cognitive Decline
Head‐to‐head comparison of Relative Cerebral Blood Flow derived from [<sup>18</sup>F]florbetapir and [<sup>18</sup>F]flortaucipir in subjects with Subjective Cognitive Decline Open
Background Several studies validated R 1 as a marker for relative cerebral blood flow (rCBF). However, the similarities or differences of R 1 estimates obtained from different PET tracers has never been investigated. Aim The aim of the cur…
View article: An artificial intelligence method using 18F-FDG PET maximum intensity projections to predict 2-year time-to-progression in diffuse large B-cell lymphoma patients
An artificial intelligence method using 18F-FDG PET maximum intensity projections to predict 2-year time-to-progression in diffuse large B-cell lymphoma patients Open
Convolutional neural networks (CNNs) may improve response prediction in diffuse large B-cell lymphoma (DLBCL). The aim of this study was to investigate the feasibility of a CNN using maximum intensity projection (MIP) images from 18 F-fluo…
View article: Tau pathology as determinant of changes in atrophy and cerebral blood flow: a multi-modal longitudinal imaging study
Tau pathology as determinant of changes in atrophy and cerebral blood flow: a multi-modal longitudinal imaging study Open
View article: Genetically identical twin-pair difference models support the amyloid cascade hypothesis
Genetically identical twin-pair difference models support the amyloid cascade hypothesis Open
The amyloid cascade hypothesis has strongly impacted the Alzheimer's disease research agenda and clinical trial designs over the past decades, but precisely how amyloid-β pathology initiates the aggregation of neocortical tau remains uncle…
View article: Cognitive performance in multiple sclerosis: what is the role of the gamma-aminobutyric acid system?
Cognitive performance in multiple sclerosis: what is the role of the gamma-aminobutyric acid system? Open
Cognitive impairment occurs in 40–65% of persons with multiple sclerosis and may be related to alterations in glutamatergic and GABAergic neurotransmission. Therefore, the aim of this study was to determine how glutamatergic and GABAergic …
View article: Tau protein spreads through functionally connected neurons in Alzheimer’s disease
Tau protein spreads through functionally connected neurons in Alzheimer’s disease Open
Background Recent studies in Alzheimer’s disease (AD) suggest that tau proteins spread through the brain following neuronal connections. Several mechanisms could be involved in this process: spreading between brain regions that interact st…
View article: A scale space theory based motion correction approach for dynamic PET brain imaging studies
A scale space theory based motion correction approach for dynamic PET brain imaging studies Open
Aim/Introduction: Patient head motion poses a significant challenge when performing dynamic PET brain studies. In response, we developed a fast, robust, easily implementable and tracer-independent brain motion correction technique that fac…
View article: Precision estimates of relative and absolute cerebral blood flow in Alzheimer’s disease and cognitively normal individuals
Precision estimates of relative and absolute cerebral blood flow in Alzheimer’s disease and cognitively normal individuals Open
Alzheimer’s disease is characterized by regional reductions in cerebral blood flow (CBF). Although the gold standard for measuring CBF is [ 15 O]H 2 O PET, proxies of relative CBF, derived from the early distribution phase of amyloid and t…
View article: Genetically identical twins show comparable tau PET load and spatial distribution.
Genetically identical twins show comparable tau PET load and spatial distribution. Open
Tau accumulation starts during the preclinical phase of Alzheimer's disease and is closely associated with cognitive decline. For preventive purposes, it is important to identify factors associated with tau accumulation and spread. Studyin…