Sander Kersten
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Blueberries Reduce Palm Oil‐Induced Metabolic Endotoxemia in an In Vitro Human Intestinal‐Immune Cell Model Open
Metabolic endotoxemia (ME), a dietary lipid‐induced increase in plasma LPS levels, is associated with cardiometabolic conditions. Accumulating evidence suggests an association between berry consumption and reduced endotoxemia. However, the…
Weight cycling-induced hypothalamic and metabolic tissue immune remodeling is uncoupled from metabolic dysfunctions Open
Background Obesity-induced insulin resistance is associated with white adipose tissue (WAT) and liver inflammation, which are both mitigated by weight loss. However, most individuals undergoing weight loss will regain lost weight, resultin…
Drug-target Mendelian randomization analysis supports lowering plasma ANGPTL3, ANGPTL4, and APOC3 levels as strategies for reducing cardiovascular disease risk Open
Aims APOC3, ANGPTL3, and ANGPTL4 are circulating proteins that are actively pursued as pharmacological targets to treat dyslipidaemia and reduce the risk of atherosclerotic cardiovascular disease. Here, we used human genetic data to compar…
Drug-target Mendelian randomization analysis supports lowering plasma ANGPTL3, ANGPTL4, and APOC3 levels as strategies for reducing cardiovascular disease risk Open
Background and Aims APOC3, ANGPTL3, and ANGPTL4 are circulating proteins that are actively pursued as pharmacological targets to treat dyslipidemia and reduce the risk of atherosclerotic cardiovascular disease. Here, we used human genetic …
View article: Are postprandial glucose responses sufficiently person-specific to use in personalized dietary advice? Design of the RepEAT study: a fully controlled dietary intervention to determine the variation in glucose responses
Are postprandial glucose responses sufficiently person-specific to use in personalized dietary advice? Design of the RepEAT study: a fully controlled dietary intervention to determine the variation in glucose responses Open
Introduction An elevated postprandial glucose response is associated with an increased risk of cardiometabolic diseases. Existing research suggests large heterogeneity in the postprandial glucose responses to identical meals and food produ…
Pretreatment with P2Y12 inhibitors and relationship with clinical outcomes in NSTEMI: Analysis of 2 Argentinian registries Open
Introduction Pretreatment with P2Y12 inhibitors has been widely studied in the context of NSTEMI patients, with varying results. General consensus is that this strategy should be avoided, unless a long wait time is expected before angiogra…
THU308 Metabolic And Neuroendocrine Adaptability Following One Night Of Partial Sleep Restriction In Dutch Males Open
Disclosure: I. Pelsma: None. R. van den Berg: None. S. Kooijman: None. M. Snel: None. G. Zhu: None. A. Moore: Employee; Self; Unilever. J. Pople: Employee; Self; Unilever. S. Lavrijsen: None. M. Birch-Machin: None. R. Bhogal: Employee; Sel…
Triacylglycerol uptake and handling by macrophages: From fatty acids to lipoproteins Open
Macrophages are essential innate immune cells and form our first line of immune defense. Also known as professional phagocytes, macrophages interact and take up various particles, including lipids. Defective lipid handling can drive excess…
View article: In-depth immunometabolic profiling by measuring cellular protein translation inhibition via bioorthogonal noncanonical amino acid tagging (CENCAT)
In-depth immunometabolic profiling by measuring cellular protein translation inhibition via bioorthogonal noncanonical amino acid tagging (CENCAT) Open
Motivation Extracellular Flux (XF) analysis has been a key technique in immunometabolism research, measuring cellular oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) to determine immune cell metabolic profiles. Ho…
Muscle-specific ER-associated degradation maintains postnatal muscle hypertrophy and systemic energy metabolism Open
The growth of skeletal muscle relies on a delicate equilibrium between protein synthesis and degradation; however, how proteostasis is managed in the endoplasmic reticulum (ER) is largely unknown. Here, we report that the SEL1L-HRD1 ER-ass…
View article: Angiopoietin-like 4 dictates the day-night rhythm of metabolic brown adipose tissue activity
Angiopoietin-like 4 dictates the day-night rhythm of metabolic brown adipose tissue activity Open
iBAT sBAT 0.0 0.5 1.0 1.5 2.0 3 H activity (% dose/organ)
Genetic Mimicry Analysis Reveals the Specific Lipases Targeted by the ANGPTL3-ANGPTL8 Complex and ANGPTL4 Open
Angiopoietin-like proteins, ANGPTL3, ANGPTL4, and ANGPTL8, are involved in regulating plasma lipids. In vitro and animal-based studies point to LPL and endothelial lipase (EL, LIPG) as key targets of ANGPTLs. To examine the ANGPTL mechanis…
View article: Primary tumor–derived systemic nANGPTL4 inhibits metastasis
Primary tumor–derived systemic nANGPTL4 inhibits metastasis Open
Primary tumors and distant site metastases form a bidirectionally communicating system. Yet, the molecular mechanisms of this crosstalk are poorly understood. Here, we identified the proteolytically cleaved fragments of angiopoietin-like 4…