Sandhya Manohar
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View article: Multicenter Insights into Peritoneal Dialysis for Autosomal Dominant Polycystic Kidney Disease
Multicenter Insights into Peritoneal Dialysis for Autosomal Dominant Polycystic Kidney Disease Open
Key Points This study demonstrates that peritoneal dialysis is a safe and feasible option for patients with autosomal dominant polycystic kidney disease, even with high cystic organ volumes. Larger organ volumes, including height-adjusted …
View article: Effect of an Interdisciplinary CKD Clinic on Disease Progression, Health Care Use, and Social Determinants of Health
Effect of an Interdisciplinary CKD Clinic on Disease Progression, Health Care Use, and Social Determinants of Health Open
Key Points Patient-centered care in an interdisciplinary CKD clinic addresses complex needs and supports comprehensive CKD management. Implementation of an interdisciplinary CKD clinic reduced hospital admissions by 26%, emergency departme…
View article: Localized K63 Ubiquitin Signaling Is Regulated by VCP/p97 During Oxidative Stress
Localized K63 Ubiquitin Signaling Is Regulated by VCP/p97 During Oxidative Stress Open
Under stress conditions, cells reprogram their molecular machineries to mitigate damage and promote survival. Ubiquitin signaling is globally increased during oxidative stress, controlling protein fate and supporting stress defenses at sev…
View article: Telehealth versus face-to-face visits: A comprehensive outpatient perspective-based cohort study of patients with kidney disease
Telehealth versus face-to-face visits: A comprehensive outpatient perspective-based cohort study of patients with kidney disease Open
Background Telenephrology has become an important health care delivery modality during the COVID-19 pandemic. However, little is known about patient perspectives on the quality of care provided via telenephrology compared to face-to-face v…
View article: Telehealth versus face-to-face visits: A comprehensive outpatient perspective-based cohort study of patients with kidney disease
Telehealth versus face-to-face visits: A comprehensive outpatient perspective-based cohort study of patients with kidney disease Open
Background Telenephrology has become an important health care delivery modality during the COVID-19 pandemic. However, little is known about patient perspectives on the quality of care provided via telenephrology compared to face-to-face v…
View article: Cell Cycle Progression Defects and Impaired DNA Damage Signaling Drive Enlarged Cells into Senescence
Cell Cycle Progression Defects and Impaired DNA Damage Signaling Drive Enlarged Cells into Senescence Open
View article: Rituximab-Associated Flare of Cryoglobulinemic Vasculitis
Rituximab-Associated Flare of Cryoglobulinemic Vasculitis Open
View article: Hemoglobinuria in the Early Poststem-Cell–Transplant Period: Risk Factors and Association with Outcomes
Hemoglobinuria in the Early Poststem-Cell–Transplant Period: Risk Factors and Association with Outcomes Open
Key Points Post-HSCT hemoglobinuria was associated with graft type (BMT+Cord). Post-HSCT hemoglobinuria was associated with early (48–72 hours) post-HSCT AKI. Graft type (BMT+Cord) was associated with AKI among patients with hemoglobinuria…
View article: Systematic Review of Risk factors and Incidence of Acute Kidney Injury Among Patients Treated with CAR-T Cell Therapies
Systematic Review of Risk factors and Incidence of Acute Kidney Injury Among Patients Treated with CAR-T Cell Therapies Open
Immunotherapy has grown significantly in the management of hematological and solid organ tumors. In-depth knowledge of T-cell pathways has led to the development of adoptive cell transfer techniques and subsequent evolution of chimeric ant…
View article: Biomarkers, Clinical Features, and Rechallenge for Immune Checkpoint Inhibitor Renal Immune-Related Adverse Events
Biomarkers, Clinical Features, and Rechallenge for Immune Checkpoint Inhibitor Renal Immune-Related Adverse Events Open
View article: Ultrasonographic Assessment of Extravascular Lung Water in Hospitalized Patients Requiring Hemodialysis: A Prospective Observational Study
Ultrasonographic Assessment of Extravascular Lung Water in Hospitalized Patients Requiring Hemodialysis: A Prospective Observational Study Open
Introduction: Sonographic technologies can estimate extravascular lung water (EVLW) in hemodialysis (HD) patients. This study investigated the suitability of a handheld scanner in contrast to a portable scanner for quantifyin…
View article: Abdominal Pain in a Patient with Hypercalcemia
Abdominal Pain in a Patient with Hypercalcemia Open
### Case Answer
A 56-year-old woman with a medical history of hypertension, diabetes, and obesity presented to the emergency room with abdominal pain. She was on losartan/hydrochlorothiazide and dapagliflogin. Computed-tomography imaging …
View article: Clinical Features and Outcomes of Immune Checkpoint Inhibitor–Associated AKI: A Multicenter Study
Clinical Features and Outcomes of Immune Checkpoint Inhibitor–Associated AKI: A Multicenter Study Open
Significance Statement Kidney toxicity from use of immune checkpoint inhibitors is being recognized as an increasingly frequent complication of treatment. However, existing data on immune checkpoint inhibitor–associated AKI have been limit…
View article: Acute Interstitial Nephritis and Checkpoint Inhibitor Therapy
Acute Interstitial Nephritis and Checkpoint Inhibitor Therapy Open
Background The objective of this case cohort study was to describe our experience in the care of patients with immune checkpoint inhibitor–related acute interstitial nephritis (ICI-AIN) including rechallenge. Methods A descriptive case ser…
View article: Systematic Review of the Safety of Immune Checkpoint Inhibitors Among Kidney Transplant Patients
Systematic Review of the Safety of Immune Checkpoint Inhibitors Among Kidney Transplant Patients Open
View article: Interstitial nephritis in immune checkpoint inhibitor therapy
Interstitial nephritis in immune checkpoint inhibitor therapy Open
View article: Ibrutinib induced acute tubular injury: A case series and review of the literature
Ibrutinib induced acute tubular injury: A case series and review of the literature Open
Over the last few years, treatment of chronic lymphocytic leukemia (CLL) has slowly started to evolve from regimens with significant impact on long-term outcomes and associated concomitant toxicities to the use of novel agents that specifi…
View article: Crystalglobulin-Induced Nephropathy and Keratopathy
Crystalglobulin-Induced Nephropathy and Keratopathy Open
View article: Programmed cell death protein 1 inhibitor treatment is associated with acute kidney injury and hypocalcemia: meta-analysis
Programmed cell death protein 1 inhibitor treatment is associated with acute kidney injury and hypocalcemia: meta-analysis Open
Treatment with PD-1 inhibitors is associated with a higher risk of AKI compared with non-nephrotoxic agents. It will be important to characterize the AKI patients to better understand the etiology behind the event. In addition, treatment w…
View article: Total Renal Artery Occlusion: Recovery of Function After Revascularization
Total Renal Artery Occlusion: Recovery of Function After Revascularization Open
View article: Therapeutic Approach to the Management of Severe Asymptomatic Hyponatremia
Therapeutic Approach to the Management of Severe Asymptomatic Hyponatremia Open
Hyponatremia is an electrolyte imbalance encountered commonly in the hospital and ambulatory settings. It can be seen in isolation or present as a complication of other medical conditions. It is therefore a challenge to determine the appro…
View article: An Unusual Case of Crescentic Lupus Nephritis Presenting With Normal Renal Function
An Unusual Case of Crescentic Lupus Nephritis Presenting With Normal Renal Function Open
Lupus nephritis is a life-threatening manifestation of systemic lupus erythematosus (SLE). This is commonly suspected when lupus patients present with elevated serum creatinine levels. But it is important to be aware that even patients wit…
View article: Is This Right Ventricular Infarction or Brugada Syndrome?
Is This Right Ventricular Infarction or Brugada Syndrome? Open
View article: Fever-Induced Brugada Syndrome
Fever-Induced Brugada Syndrome Open
Brugada syndrome is increasingly recognized as a cause of sudden cardiac death. Many of these patients do not get diagnosed due its dynamic and often hidden nature. We have come a long way in understanding the disease process, and its elec…