Sandhya Rajkumar
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View article: Longitudinal adipose tissue single cell transcriptomics reveals genes and variants regulating weight loss after bariatric surgery
Longitudinal adipose tissue single cell transcriptomics reveals genes and variants regulating weight loss after bariatric surgery Open
Ability to lose weight during different obesity treatments shows substantial variability between individuals and is likely under genetic control; however, the underlying predictive variants and weight loss genes remain unknown. Here we pro…
View article: Correction to: Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes
Correction to: Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes Open
View article: Integration of single cell omics with biobank data discovers<i>trans</i>effects of<i>SREBF1</i>abdominal obesity risk variants on adipocyte expression of more than 100 genes
Integration of single cell omics with biobank data discovers<i>trans</i>effects of<i>SREBF1</i>abdominal obesity risk variants on adipocyte expression of more than 100 genes Open
Given the fast-increasing prevalence of obesity and its comorbidities, it would be critical to improve our understanding of the cell-type level differences between the two key human adipose tissue depots, subcutaneous (SAT) and visceral ad…
View article: An abdominal obesity missense variant in the adipocyte thermogenesis gene TBX15 is implicated in adaptation to cold in Finns
An abdominal obesity missense variant in the adipocyte thermogenesis gene TBX15 is implicated in adaptation to cold in Finns Open
Mechanisms of abdominal obesity GWAS variants have remained largely unknown. To elucidate these mechanisms, we leveraged subcutaneous adipose tissue (SAT) single nucleus RNA-sequencing and genomics data. After discovering that heritability…
View article: Cross-Tissue Single-Nucleus RNA Sequencing Discovers Tissue-Resident Adipocytes Involved in Propanoate Metabolism in the Human Heart
Cross-Tissue Single-Nucleus RNA Sequencing Discovers Tissue-Resident Adipocytes Involved in Propanoate Metabolism in the Human Heart Open
BACKGROUND: Adipocytes are crucial regulators of cardiovascular health. However, not much is known about gene expression profiles of adipocytes residing in nonfat cardiovascular tissues, their genetic regulation, and contribution to corona…
View article: Correction to: Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes
Correction to: Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes Open
View article: Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes
Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes Open