Sandi R. Wilkenfeld
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View article: Cholesterol metabolism regulated by CAMKK2-CREB signaling promotes castration-resistant prostate cancer
Cholesterol metabolism regulated by CAMKK2-CREB signaling promotes castration-resistant prostate cancer Open
Castration-resistant prostate cancer (CRPC) remains an incurable disease in need of improved treatments. CAMKK2 is an emerging therapeutic target whose oncogenic effects in prostate cancer have, to date, been largely attributed to its acti…
View article: Inhibition of CAMKK2 impairs autophagy and castration-resistant prostate cancer via suppression of AMPK-ULK1 signaling
Inhibition of CAMKK2 impairs autophagy and castration-resistant prostate cancer via suppression of AMPK-ULK1 signaling Open
Previous work has suggested androgen receptor (AR) signaling mediates cancer progression in part through the modulation of autophagy. Accordingly, we demonstrate that chloroquine, an inhibitor of autophagy, can inhibit tumor growth in prec…
View article: GLUT12 promotes prostate cancer cell growth and is regulated by androgens and CaMKK2 signaling
GLUT12 promotes prostate cancer cell growth and is regulated by androgens and CaMKK2 signaling Open
Despite altered metabolism being an accepted hallmark of cancer, it is still not completely understood which signaling pathways regulate these processes. Given the central role of androgen receptor (AR) signaling in prostate cancer, we hyp…