Sandip Kar
YOU?
Author Swipe
View article: Subtle alteration in transcriptional memory governs the lineage-level cell cycle duration heterogeneities of mammalian cells
Subtle alteration in transcriptional memory governs the lineage-level cell cycle duration heterogeneities of mammalian cells Open
Cell cycle duration heterogeneities within a malignant tumor significantly reduce the therapeutic efficacy of cancer treatment. However, identifying factors governing such heterogeneities remains challenging. Herein, we perform a computati…
View article: Subtle alteration in transcriptional memory governs the lineage-level cell cycle duration heterogeneities of mammalian cells
Subtle alteration in transcriptional memory governs the lineage-level cell cycle duration heterogeneities of mammalian cells Open
Cell cycle duration heterogeneities within a malignant tumor significantly reduce the therapeutic efficacy of cancer treatment. However, identifying factors governing such heterogeneities remains challenging. Here, we demonstrate that corr…
View article: Role of microRNAs in oncogenesis: Insights from computational and systems-level modeling approaches
Role of microRNAs in oncogenesis: Insights from computational and systems-level modeling approaches Open
MicroRNAs (miRNAs) are short (~22 nucleotides) non-coding RNAs that are often intricately integrated into the regulatory networks of various cellular processes and govern the cell fate decision making events associated with oncogenesis by …
View article: Understanding the dynamics of complex<i>in-situ</i>enzyme-catalyzed reactions undergoing mechanical stress
Understanding the dynamics of complex<i>in-situ</i>enzyme-catalyzed reactions undergoing mechanical stress Open
Understanding the diversity in the enzymatic mechanism have utmost importance as it can temporally control the catalytic efficiency. Recent literature suggests that by influencing mechanical properties of hybrid materials, the catalytic ef…
View article: Modulation of signaling cross-talk between pJNK and pAKT generates optimal apoptotic response
Modulation of signaling cross-talk between pJNK and pAKT generates optimal apoptotic response Open
Tumor necrosis factor alpha (TNFα) is a well-known modulator of apoptosis by maintaining a balance between proliferation and cell-death in normal cells. Cancer cells often evade apoptotic response following TNFα stimulation by altering sig…
View article: Transcriptional fluctuations govern the serum dependent cell cycle duration heterogeneities in Mammalian cells
Transcriptional fluctuations govern the serum dependent cell cycle duration heterogeneities in Mammalian cells Open
Mammalian cells exhibit a high degree of intercellular variability in cell cycle period and phase durations. However, the factors orchestrating the cell cycle duration heterogeneities remain unclear. Herein, by combining cell cycle network…
View article: Unraveling the intracellular cross-talk governing the balance between TNF<i>α</i>mediated survival and apoptosis signaling
Unraveling the intracellular cross-talk governing the balance between TNF<i>α</i>mediated survival and apoptosis signaling Open
Tumor necrosis factor alpha (TNF α ), a pleiotropic cytokine, helps maintain a balance between proliferation and apoptosis in normal cells. This balance is often sacrificed in a diseased cell, such as that of a cancer, by preferring surviv…
View article: Role of microRNAs in oncogenesis: Insights from computational and systems‐level modeling approaches
Role of microRNAs in oncogenesis: Insights from computational and systems‐level modeling approaches Open
MicroRNAs (miRNAs) often govern the cell fate decision‐making events associated with oncogenesis. miRNAs repress the target genes either by degrading the target mRNA or inhibiting the process of translation. However, mathematical and compu…
View article: Incoherent modulation of bi-stable dynamics orchestrates the Mushroom and Isola bifurcations
Incoherent modulation of bi-stable dynamics orchestrates the Mushroom and Isola bifurcations Open
In biological networks, steady state dynamics of cell-fate regulatory genes often exhibit Mushroom and Isola kind of bifurcations. How these complex bifurcations emerge for these complex networks, and what are the minimal network structure…
View article: Unraveling the origin of Glucose mediated disparate proliferation dynamics of Cancer stem cells
Unraveling the origin of Glucose mediated disparate proliferation dynamics of Cancer stem cells Open
Cancer stem cells (CSCs) often switch on their self-renewal programming aggressively to cause a relapse of cancer. Intriguingly, glucose differentially triggers the proliferation propensities in CSCs in an origin-dependent manner by contro…
View article: Emergence of a Promiscuous Peroxidase Under Non-Equilibrium Conditions
Emergence of a Promiscuous Peroxidase Under Non-Equilibrium Conditions Open
In the far from equilibrium state of living matter, energy is consumed to fuel the metabolic networks of enzymatic reactions. The emergence of protometabolic pathways in primeval earth is intricately related to the evolutionary journey of …
View article: Emergence of a Promiscuous Peroxidase Under Non-Equilibrium Conditions
Emergence of a Promiscuous Peroxidase Under Non-Equilibrium Conditions Open
In the far from equilibrium state of living matter, energy is consumed to fuel the metabolic networks of enzymatic reactions. The emergence of protometabolic pathways in primeval earth is intricately related to the evolutionary journey of …
View article: A generic approach to decipher the mechanistic pathway of heterogeneous protein aggregation kinetics
A generic approach to decipher the mechanistic pathway of heterogeneous protein aggregation kinetics Open
Amyloid formation is a generic property of many protein/polypeptide chains.
View article: Fine‐tuning Nanog expression heterogeneity in embryonic stem cells by regulating a Nanog transcript‐specific microRNA
Fine‐tuning Nanog expression heterogeneity in embryonic stem cells by regulating a Nanog transcript‐specific microRNA Open
In embryonic stem cells (ESCs), the transcription factor Nanog maintains the stemness of ESCs despite exhibiting heterogeneous expression patterns under varied culture conditions. Efficient fine‐tuning of Nanog expression heterogeneity cou…
View article: Fine-tuning Nanog expression heterogeneity by altering MicroRNA regulation
Fine-tuning Nanog expression heterogeneity by altering MicroRNA regulation Open
Nanog exhibits a robust heterogeneous expression pattern within a population of embryonic stem cells (ESCs) under varied culture conditions. However, an efficient way to fine-tune the Nanog expression heterogeneity remains elusive. Herein,…
View article: Investigating the effect of circularly polarized electric field on spatially extended Gray-Scott model
Investigating the effect of circularly polarized electric field on spatially extended Gray-Scott model Open
Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai-400 076, India E-mail: [email protected] Manuscript received online 22 April 2019, revised and accepted 15 May 2019 According to Turing’s hypothesis, the spat…
View article: Dynamical reorganization of transcriptional events governs robust Nanog heterogeneity
Dynamical reorganization of transcriptional events governs robust Nanog heterogeneity Open
Nanog maintains pluripotency of embryonic stem cells (ESC's), while demonstrating high expression heterogeneity within an ESC population. Intriguingly, in ESC's, the overall heterogeneity at the Nanog mRNA level under various culture condi…
View article: Disproportionate feedback interactions govern cell‐type specific proliferation in mammalian cells
Disproportionate feedback interactions govern cell‐type specific proliferation in mammalian cells Open
In mammalian cells, the decision to maintain quiescence over proliferation commitment during G 1 ‐S transition depends on more than one intertwined feedback interaction and is highly cell‐type dependent. However, the precise role played by…
View article: Alteration in microRNA‐17‐92 dynamics accounts for differential nature of cellular proliferation
Alteration in microRNA‐17‐92 dynamics accounts for differential nature of cellular proliferation Open
MicroRNAs associated with the mir‐17‐92 cluster are crucial regulators of the mammalian cell cycle, as they inhibit transcription factors related to the E2F family that tightly control decision‐making events for a cell to commit for active…
View article: Subtle alteration in microRNA dynamics accounts for differential nature of cellular proliferation
Subtle alteration in microRNA dynamics accounts for differential nature of cellular proliferation Open
In the G 1 phase of the mammalian cell cycle, a bi-stable steady state dynamics of the transcription factor E2F ensures that only a certain threshold level of the growth factor can induce a high expression level (on state) of E2F to initia…
View article: Deciphering the dynamical origin of mixed population during neural stem cell developmental lineage commitment
Deciphering the dynamical origin of mixed population during neural stem cell developmental lineage commitment Open
Neural stem cells (NSC's) often give rise to mixed population of cells during differentiation. However, the dynamical origin of these mixed states is poorly understood. In this article, our mathematical modeling study demonstrates that the…
View article: Protein abundance of AKT and ERK pathway components governs cell type‐specific regulation of proliferation
Protein abundance of AKT and ERK pathway components governs cell type‐specific regulation of proliferation Open
Signaling through the AKT and ERK pathways controls cell proliferation. However, the integrated regulation of this multistep process, involving signal processing, cell growth and cell cycle progression, is poorly understood. Here, we study…
View article: Unraveling the differential dynamics of developmental fate in central and peripheral nervous systems
Unraveling the differential dynamics of developmental fate in central and peripheral nervous systems Open
Bone morphogenetic protein 2 (BMP2), differentially regulates the developmental lineage commitment of neural stem cells (NSC’s) in central and peripheral nervous systems. However, the precise mechanism beneath such observations still remai…
View article: Unraveling the differential dynamics of developmental fate in central and peripheral nervous systems
Unraveling the differential dynamics of developmental fate in central and peripheral nervous systems Open
Bone morphogenetic protein 2 (BMP2), differentially regulates the developmental lineage commitment of neural stem cells (NSC’s) in central and peripheral nervous systems. However, the precise mechanism beneath such observations still remai…
View article: Are Quasi-Steady-State Approximated Models Suitable for Quantifying Intrinsic Noise Accurately?
Are Quasi-Steady-State Approximated Models Suitable for Quantifying Intrinsic Noise Accurately? Open
Large gene regulatory networks (GRN) are often modeled with quasi-steady-state approximation (QSSA) to reduce the huge computational time required for intrinsic noise quantification using Gillespie stochastic simulation algorithm (SSA). Ho…